IPO7

Importin 7
Identifiers
Symbols	IPO7 ; FLJ14581; MGC138673; RANBP7
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4659
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Importin 7, also known as IPO7, is a human gene.

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

Further reading

• Görlich D, Dabrowski M, Bischoff FR; et al. (1997). "A novel class of RanGTP binding proteins". J. Cell Biol. 138 (1): 65–80. PMID 9214382.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMID 9687515.
• Paraskeva E, Izaurralde E, Bischoff FR; et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm". J. Cell Biol. 145 (2): 255–64. PMID 10209022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jäkel S, Albig W, Kutay U; et al. (1999). "The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1". EMBO J. 18 (9): 2411–23. doi:10.1093/emboj/18.9.2411. PMID 10228156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dean KA, von Ahsen O, Görlich D, Fried HM (2001). "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin". J. Cell. Sci. 114 (Pt 19): 3479–85. PMID 11682607.CS1 maint: Multiple names: authors list (link)
• Bäuerle M, Doenecke D, Albig W (2002). "The requirement of H1 histones for a heterodimeric nuclear import receptor". J. Biol. Chem. 277 (36): 32480–9. doi:10.1074/jbc.M202765200. PMID 12080050.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fassati A, Görlich D, Harrison I; et al. (2003). "Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7". EMBO J. 22 (14): 3675–85. doi:10.1093/emboj/cdg357. PMID 12853482.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3". Mol. Cell. Biol. 24 (16): 7091–101. doi:10.1128/MCB.24.16.7091-7101.2004. PMID 15282309.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kahle J, Baake M, Doenecke D, Albig W (2005). "Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13". Mol. Cell. Biol. 25 (13): 5339–54. doi:10.1128/MCB.25.13.5339-5354.2005. PMID 15964792.CS1 maint: Multiple names: authors list (link)
• Arnold M, Nath A, Hauber J, Kehlenbach RH (2006). "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1". J. Biol. Chem. 281 (30): 20883–90. doi:10.1074/jbc.M602189200. PMID 16704975.CS1 maint: Multiple names: authors list (link)
• Zaitseva L, Myers R, Fassati A (2007). "tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes". PLoS Biol. 4 (10): e332. doi:10.1371/journal.pbio.0040332. PMID 17020411.CS1 maint: Multiple names: authors list (link)
• Saijou E, Itoh T, Kim KW; et al. (2007). "Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms". J. Biol. Chem. 282 (44): 32327–37. doi:10.1074/jbc.M706793200. PMID 17848547.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)