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{{Infobox_gene}}
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'''Inhibitor of growth protein 3''' is a [[protein]] that in humans is encoded by the ''ING3'' [[gene]].<ref name="pmid12080476">{{cite journal |vauthors=Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K | title = Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers | journal = Oncogene | volume = 21 | issue = 28 | pages = 4462–70 |date=Jun 2002 | pmid = 12080476 | pmc =  | doi = 10.1038/sj.onc.1205540 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ING3 inhibitor of growth family, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54556| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ING3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x4i.
| PDB = {{PDB2|1x4i}}
| Name = Inhibitor of growth family, member 3
| HGNCid = 14587
| Symbol = ING3
| AltSymbols =; ING2; Eaf4; FLJ20089; p47ING3
| OMIM = 607493
| ECnumber = 
| Homologene = 6804
| MGIid = 1919027
| GeneAtlas_image1 = PBB_GE_ING3_205070_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54556
    | Hs_Ensembl = ENSG00000071243
    | Hs_RefseqProtein = NP_061944
    | Hs_RefseqmRNA = NM_019071
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 120378053
    | Hs_GenLoc_end = 120402938
    | Hs_Uniprot = Q9NXR8
    | Mm_EntrezGene = 71777
    | Mm_Ensembl = ENSMUSG00000029670
    | Mm_RefseqmRNA = NM_023626
    | Mm_RefseqProtein = NP_076115
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 21899647
    | Mm_GenLoc_end = 21926038
    | Mm_Uniprot = Q3V3Y2
  }}
}}
'''Inhibitor of growth family, member 3''', also known as '''ING3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ING3 inhibitor of growth family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54556| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: ING3 inhibitor of growth family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54556| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147-54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
*{{cite journal  |vauthors=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147–54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal  | author=Gunduz M, Ouchida M, Fukushima K, ''et al.'' |title=Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. |journal=Oncogene |volume=21 |issue= 28 |pages= 4462-70 |year= 2002 |pmid= 12080476 |doi= 10.1038/sj.onc.1205540 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Nagashima M |title=A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis |journal=Oncogene |volume=22 |issue= 3 |pages= 343–50 |year= 2003 |pmid= 12545155 |doi= 10.1038/sj.onc.1206115 |name-list-format=vanc| author2=Shiseki M  | author3=Pedeux RM  | display-authors=3  | last4=Okamura  | first4=Shu  | last5=Kitahama-Shiseki  | first5=Mariko  | last6=Miura  | first6=Koh  | last7=Yokota  | first7=Jun  | last8=Harris  | first8=Curtis C }}
*{{cite journal  | author=Nagashima M, Shiseki M, Pedeux RM, ''et al.'' |title=A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. |journal=Oncogene |volume=22 |issue= 3 |pages= 343-50 |year= 2003 |pmid= 12545155 |doi= 10.1038/sj.onc.1206115 }}
*{{cite journal  | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |name-list-format=vanc| author2=Fulton RS  | author3=Fulton LA  | display-authors=3  | last4=Graves  | first4=Tina A.  | last5=Pepin  | first5=Kymberlie H.  | last6=Wagner-Mcpherson  | first6=Caryn  | last7=Layman  | first7=Dan  | last8=Maas  | first8=Jason  | last9=Jaeger  | first9=Sara }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Cai Y |title=Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 42733–6 |year= 2003 |pmid= 12963728 |doi= 10.1074/jbc.C300389200 |name-list-format=vanc| author2=Jin J  | author3=Tomomori-Sato C  | display-authors=3  | last4=Sato  | first4=S  | last5=Sorokina  | first5=I  | last6=Parmely  | first6=TJ  | last7=Conaway  | first7=RC  | last8=Conaway  | first8=JW }}
*{{cite journal  | author=Cai Y, Jin J, Tomomori-Sato C, ''et al.'' |title=Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 42733-6 |year= 2003 |pmid= 12963728 |doi= 10.1074/jbc.C300389200 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Doyon Y |title=Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1884–96 |year= 2004 |pmid= 14966270 |doi=10.1128/MCB.24.5.1884-1896.2004  | pmc=350560  |name-list-format=vanc| author2=Selleck W  | author3=Lane WS  | display-authors=3  | last4=Tan  | first4=S.  | last5=Cote  | first5=J. }}
*{{cite journal  | author=Doyon Y, Selleck W, Lane WS, ''et al.'' |title=Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1884-96 |year= 2004 |pmid= 14966270 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Cai Y |title=The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13665–70 |year= 2005 |pmid= 15647280 |doi= 10.1074/jbc.M500001200 |name-list-format=vanc| author2=Jin J  | author3=Florens L  | display-authors=3  | last4=Swanson  | first4=SK  | last5=Kusch  | first5=T  | last6=Li  | first6=B  | last7=Workman  | first7=JL  | last8=Washburn  | first8=MP  | last9=Conaway  | first9=RC }}
*{{cite journal  | author=Cai Y, Jin J, Florens L, ''et al.'' |title=The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13665-70 |year= 2005 |pmid= 15647280 |doi= 10.1074/jbc.M500001200 }}
*{{cite journal  |vauthors=Wang Y, Dai DL, Martinka M, Li G |title=Prognostic significance of nuclear ING3 expression in human cutaneous melanoma |journal=Clin. Cancer Res. |volume=13 |issue= 14 |pages= 4111–6 |year= 2007 |pmid= 17634537 |doi= 10.1158/1078-0432.CCR-07-0408 }}
*{{cite journal  | author=Wang Y, Dai DL, Martinka M, Li G |title=Prognostic significance of nuclear ING3 expression in human cutaneous melanoma. |journal=Clin. Cancer Res. |volume=13 |issue= 14 |pages= 4111-6 |year= 2007 |pmid= 17634537 |doi= 10.1158/1078-0432.CCR-07-0408 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=54556}}
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Latest revision as of 23:52, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.[1][2]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.[2]

References

  1. ↑ Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K (Jun 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70. doi:10.1038/sj.onc.1205540. PMID 12080476.
  2. ↑ 2.0 2.1 "Entrez Gene: ING3 inhibitor of growth family, member 3".

Further reading



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