ING2

Inhibitor of growth family, member 2
PDB rendering based on 1wes.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wes​, 2g6q​
Identifiers
Symbols	ING2 ; ING1L; p33ING2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20388
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Inhibitor of growth family, member 2, also known as ING2, is a human gene.

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Shimada Y, Saito A, Suzuki M; et al. (1999). "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor". Cytogenet. Cell Genet. 83 (3–4): 232–5. PMID 10072587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagashima M, Shiseki M, Miura K; et al. (2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9671–6. doi:10.1073/pnas.161151798. PMID 11481424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuzmichev A, Zhang Y, Erdjument-Bromage H; et al. (2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Mol. Cell. Biol. 22 (3): 835–48. PMID 11784859.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gozani O, Karuman P, Jones DR; et al. (2003). "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor". Cell. 114 (1): 99–111. PMID 12859901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sironi E, Cerri A, Tomasini D; et al. (2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes". J. Cutan. Pathol. 31 (4): 318–22. PMID 15005689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro". Nucleic Acids Res. 32 (12): 3632–41. doi:10.1093/nar/gkh692. PMID 15243141.CS1 maint: Multiple names: authors list (link)
• He GH, Helbing CC, Wagner MJ; et al. (2005). "Phylogenetic analysis of the ING family of PHD finger proteins". Mol. Biol. Evol. 22 (1): 104–16. doi:10.1093/molbev/msh256. PMID 15356280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chin MY, Ng KC, Li G (2005). "The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells". Exp. Cell Res. 304 (2): 531–43. doi:10.1016/j.yexcr.2004.11.023. PMID 15748897.CS1 maint: Multiple names: authors list (link)
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pedeux R, Sengupta S, Shen JC; et al. (2005). "ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation". Mol. Cell. Biol. 25 (15): 6639–48. doi:10.1128/MCB.25.15.6639-6648.2005. PMID 16024799.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okano T, Gemma A, Hosoya Y; et al. (2006). "Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer". Oncol. Rep. 15 (3): 545–9. PMID 16465410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang J, Chin MY, Li G (2006). "The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation". Cancer Res. 66 (4): 1906–11. doi:10.1158/0008-5472.CAN-05-3444. PMID 16488987.CS1 maint: Multiple names: authors list (link)
• Lu F, Dai DL, Martinka M; et al. (2006). "Nuclear ING2 expression is reduced in human cutaneous melanomas". Br. J. Cancer. 95 (1): 80–6. doi:10.1038/sj.bjc.6603205. PMID 16755297.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Y, Wang J, Li G (2006). "Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis". FEBS Lett. 580 (16): 3787–93. doi:10.1016/j.febslet.2006.05.065. PMID 16782091.CS1 maint: Multiple names: authors list (link)
• Huang W, Zhang H, Davrazou F; et al. (2007). "Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling". J. Am. Chem. Soc. 129 (20): 6498–506. doi:10.1021/ja070195b. PMID 17469822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ING2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.