INADL: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''InaD-like protein''' is a [[protein]] that in humans is encoded by the ''INADL'' [[gene]].<ref name="pmid9280290">{{cite journal | vauthors = Philipp S, Flockerzi V | title = Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster | journal = FEBS Lett | volume = 413 | issue = 2 | pages = 243–8 | date = Sep 1997 | pmid = 9280290 | pmc =  | doi = 10.1016/S0014-5793(97)00877-6 }}</ref><ref name="pmid11374908">{{cite journal | vauthors = Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T | title = Isolation of novel heart-specific genes using the BodyMap database | journal = Genomics | volume = 74 | issue = 1 | pages = 115–20 | date = May 2001 | pmid = 11374908 | pmc = | doi = 10.1006/geno.2001.6527 }}</ref><ref name="entrez"/>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_INADL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d92.
| PDB = {{PDB2|2d92}}, {{PDB2|2daz}}, {{PDB2|2db5}}, {{PDB2|2dlu}}, {{PDB2|2dm8}}, {{PDB2|2dmz}}
| Name = InaD-like (Drosophila)
| HGNCid = 28881
| Symbol = INADL
| AltSymbols =; Cipp; FLJ26982; PATJ
| OMIM = 603199
| ECnumber = 
| Homologene = 72199
| MGIid = 1277960
| GeneAtlas_image1 = PBB_GE_INADL_214493_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_INADL_214705_at_tn.png
| GeneAtlas_image3 = PBB_GE_INADL_gnf1h03568_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0045177 |text = apical part of cell}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10207
    | Hs_Ensembl = ENSG00000132849
    | Hs_RefseqProtein = NP_005790
    | Hs_RefseqmRNA = NM_005799
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 61980737
    | Hs_GenLoc_end = 62402180
    | Hs_Uniprot = Q8NI35
    | Mm_EntrezGene = 12695
    | Mm_Ensembl = ENSMUSG00000061859
    | Mm_RefseqmRNA = NM_001005784
    | Mm_RefseqProtein = NP_001005784
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 97887844
    | Mm_GenLoc_end = 98211621
    | Mm_Uniprot = Q3U191
  }}
}}
'''InaD-like (Drosophila)''', also known as '''INADL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: INADL InaD-like (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.<ref name="entrez">{{cite web | title = Entrez Gene: INADL InaD-like (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.<ref name="entrez">{{cite web | title = Entrez Gene: INADL InaD-like (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207| accessdate = }}</ref>
 
}}
INADL has been shown to [[Protein-protein interaction|interact]] with [[MPP5]].<ref name=pmid11927608>{{cite journal | vauthors = Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B | title = The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 161–72 | date = Apr 2002 | pmid = 11927608 | pmc = 2173254 | doi = 10.1083/jcb.200109010  }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Fanning AS, Anderson JM | title = PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane | journal = J. Clin. Invest. | volume = 103 | issue = 6 | pages = 767–72 | year = 1999 | pmid = 10079096 | pmc = 408156 | doi = 10.1172/JCI6509 }}
| citations =
*{{cite journal | vauthors = Lennon G, Auffray C, Polymeropoulos M, Soares MB | title = The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression | journal = Genomics | volume = 33 | issue = 1 | pages = 151–2 | year = 1996 | pmid = 8617505 | doi = 10.1006/geno.1996.0177 }}
*{{cite journal | author=Fanning AS, Anderson JM |title=PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. |journal=J. Clin. Invest. |volume=103 |issue= 6 |pages= 767-72 |year= 1999 |pmid= 10079096 |doi= }}
*{{cite journal | vauthors = Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ | title = CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins | journal = Mol. Cell. Neurosci. | volume = 11 | issue = 3 | pages = 161–72 | year = 1998 | pmid = 9647694 | doi = 10.1006/mcne.1998.0679 }}
*{{cite journal | author=Lennon G, Auffray C, Polymeropoulos M, Soares MB |title=The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. |journal=Genomics |volume=33 |issue= 1 |pages= 151-2 |year= 1996 |pmid= 8617505 |doi= 10.1006/geno.1996.0177 }}
*{{cite journal | vauthors = Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Helmer Citterich M, Cesareni G, Dente L | title = Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster | journal = J. Biol. Chem. | volume = 276 | issue = 45 | pages = 42122–30 | year = 2001 | pmid = 11509564 | doi = 10.1074/jbc.M104208200 }}
*{{cite journal | author=Philipp S, Flockerzi V |title=Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 243-8 |year= 1997 |pmid= 9280290 |doi=  }}
*{{cite journal | vauthors = Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E | title = The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons | journal = J. Biol. Chem. | volume = 277 | issue = 19 | pages = 16655–61 | year = 2002 | pmid = 11872753 | doi = 10.1074/jbc.M201087200 }}
*{{cite journal  | author=Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ |title=CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 161-72 |year= 1998 |pmid= 9647694 |doi= 10.1006/mcne.1998.0679 }}
*{{cite journal | vauthors = Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B | title = The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 161–72 | year = 2002 | pmid = 11927608 | pmc = 2173254 | doi = 10.1083/jcb.200109010 }}
*{{cite journal | author=Soejima H, Kawamoto S, Akai J, ''et al.'' |title=Isolation of novel heart-specific genes using the BodyMap database. |journal=Genomics |volume=74 |issue= 1 |pages= 115-20 |year= 2001 |pmid= 11374908 |doi= 10.1006/geno.2001.6527 }}
*{{cite journal | vauthors = Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A | title = hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells | journal = J. Biol. Chem. | volume = 277 | issue = 28 | pages = 25408–15 | year = 2002 | pmid = 11964389 | doi = 10.1074/jbc.M202196200 }}
*{{cite journal  | author=Vaccaro P, Brannetti B, Montecchi-Palazzi L, ''et al.'' |title=Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42122-30 |year= 2001 |pmid= 11509564 |doi= 10.1074/jbc.M104208200 }}
*{{cite journal | vauthors = Roh MH, Liu CJ, Laurinec S, Margolis B | title = The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions | journal = J. Biol. Chem. | volume = 277 | issue = 30 | pages = 27501–9 | year = 2002 | pmid = 12021270 | doi = 10.1074/jbc.M201177200 }}
*{{cite journal | author=Anzai N, Deval E, Schaefer L, ''et al.'' |title=The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16655-61 |year= 2002 |pmid= 11872753 |doi= 10.1074/jbc.M201087200 }}
*{{cite journal | vauthors = Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B | title = Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1) | journal = Gene | volume = 302 | issue = 1–2 | pages = 21–9 | year = 2003 | pmid = 12527193 | doi = 10.1016/S0378111902010843 }}
*{{cite journal | author=Roh MH, Makarova O, Liu CJ, ''et al.'' |title=The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 161-72 |year= 2002 |pmid= 11927608 |doi= 10.1083/jcb.200109010 }}
*{{cite journal | vauthors = Roh MH, Fan S, Liu CJ, Margolis B | title = The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells | journal = J. Cell Sci. | volume = 116 | issue = Pt 14 | pages = 2895–906 | year = 2004 | pmid = 12771187 | doi = 10.1242/jcs.00500 }}
*{{cite journal | author=Lemmers C, Médina E, Delgrossi MH, ''et al.'' |title=hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25408-15 |year= 2002 |pmid= 11964389 |doi= 10.1074/jbc.M202196200 }}
*{{cite journal | vauthors = Li Y, Karnak D, Demeler B, Margolis B, Lavie A | title = Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes | journal = EMBO J. | volume = 23 | issue = 14 | pages = 2723–33 | year = 2005 | pmid = 15241471 | pmc = 514954 | doi = 10.1038/sj.emboj.7600294 }}
*{{cite journal | author=Roh MH, Liu CJ, Laurinec S, Margolis B |title=The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27501-9 |year= 2002 |pmid= 12021270 |doi= 10.1074/jbc.M201177200 }}
*{{cite journal | vauthors = Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A | title = PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells | journal = J. Cell Sci. | volume = 118 | issue = Pt 17 | pages = 4049–57 | year = 2005 | pmid = 16129888 | doi = 10.1242/jcs.02528 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors = Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G | title = Uncovering Quantitative Protein Interaction Networks for Mouse PDZ Domains using Protein Microarrays | journal = J. Am. Chem. Soc. | volume = 128 | issue = 17 | pages = 5913–22 | year = 2007 | pmid = 16637659 | pmc = 2533859 | doi = 10.1021/ja060943h }}
*{{cite journal  | author=Makarova O, Roh MH, Liu CJ, ''et al.'' |title=Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). |journal=Gene |volume=302 |issue= 1-2 |pages= 21-9 |year= 2003 |pmid= 12527193 |doi= }}
*{{cite journal | vauthors = Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T | title = A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells | journal = Cell | volume = 125 | issue = 3 | pages = 535–48 | year = 2006 | pmid = 16678097 | doi = 10.1016/j.cell.2006.02.045 }}
*{{cite journal | author=Roh MH, Fan S, Liu CJ, Margolis B |title=The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. |journal=J. Cell. Sci. |volume=116 |issue= Pt 14 |pages= 2895-906 |year= 2004 |pmid= 12771187 |doi= 10.1242/jcs.00500 }}
*{{cite journal | author=Li Y, Karnak D, Demeler B, ''et al.'' |title=Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. |journal=EMBO J. |volume=23 |issue= 14 |pages= 2723-33 |year= 2005 |pmid= 15241471 |doi= 10.1038/sj.emboj.7600294 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Michel D, Arsanto JP, Massey-Harroche D, ''et al.'' |title=PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. |journal=J. Cell. Sci. |volume=118 |issue= Pt 17 |pages= 4049-57 |year= 2005 |pmid= 16129888 |doi= 10.1242/jcs.02528 }}
*{{cite journal | author=Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G |title=Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. |journal=J. Am. Chem. Soc. |volume=128 |issue= 17 |pages= 5913-22 |year= 2007 |pmid= 16637659 |doi= 10.1021/ja060943h }}
*{{cite journal | author=Wells CD, Fawcett JP, Traweger A, ''et al.'' |title=A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. |journal=Cell |volume=125 |issue= 3 |pages= 535-48 |year= 2006 |pmid= 16678097 |doi= 10.1016/j.cell.2006.02.045 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|INADL}}
* {{UCSC gene details|INADL}}
 
{{PDB Gallery|geneid=10207}}
 
 
{{gene-1-stub}}

Revision as of 20:06, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

InaD-like protein is a protein that in humans is encoded by the INADL gene.[1][2][3]

Function

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.[3]

Interactions

INADL has been shown to interact with MPP5.[4]

References

  1. ↑ Philipp S, Flockerzi V (Sep 1997). "Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster". FEBS Lett. 413 (2): 243–8. doi:10.1016/S0014-5793(97)00877-6. PMID 9280290.
  2. ↑ Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T (May 2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics. 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
  3. ↑ 3.0 3.1 "Entrez Gene: INADL InaD-like (Drosophila)".
  4. ↑ Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.

Further reading

External links


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