IL2RB

Interleukin 2 receptor, beta
PDB rendering based on 2b5i.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2b5i​, 2erj​
Identifiers
Symbols	IL2RB ; CD122; P70-75
External IDs	Template:OMIM5 Template:MGI HomoloGene: 47955
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Interleukin 2 receptor, beta, also known as IL2RB, is a human gene.

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

See also

• IL-2 receptor

Further reading

• Ellery JM, Nicholls PJ (2002). "Alternate signalling pathways from the interleukin-2 receptor". Cytokine Growth Factor Rev. 13 (1): 27–40. PMID 11750878.
• Purvis SF, Georges DL, Williams TM, Lederman MM (1992). "Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein". Cell. Immunol. 144 (1): 32–42. PMID 1394441.CS1 maint: Multiple names: authors list (link)
• Torigoe T, Saragovi HU, Reed JC (1992). "Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2674–8. PMID 1557373.CS1 maint: Multiple names: authors list (link)
• Maslinski W, Remillard B, Tsudo M, Strom TB (1992). "Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol". J. Biol. Chem. 267 (22): 15281–4. PMID 1639773.CS1 maint: Multiple names: authors list (link)
• Miyazaki T, Maruyama M, Yamada G; et al. (1991). "The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction". EMBO J. 10 (11): 3191–7. PMID 1915291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shibuya H, Yoneyama M, Nakamura Y; et al. (1990). "The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment". Nucleic Acids Res. 18 (13): 3697–703. PMID 1973832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hatakeyama M, Kono T, Kobayashi N; et al. (1991). "Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association". Science. 252 (5012): 1523–8. PMID 2047859.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mills GB, May C, McGill M; et al. (1990). "Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated". J. Biol. Chem. 265 (6): 3561–7. PMID 2303462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oyaizu N, Chirmule N, Kalyanaraman VS; et al. (1990). "Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2379–83. PMID 2315327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gnarra JR, Otani H, Wang MG; et al. (1990). "Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3440–4. PMID 2333293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsudo M, Kitamura F, Miyasaka M (1989). "Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1982–6. PMID 2467293.CS1 maint: Multiple names: authors list (link)
• Hatakeyama M, Tsudo M, Minamoto S; et al. (1989). "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's". Science. 244 (4904): 551–6. PMID 2785715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kornfeld H, Cruikshank WW, Pyle SW; et al. (1988). "Lymphocyte activation by HIV-1 envelope glycoprotein". Nature. 335 (6189): 445–8. doi:10.1038/335445a0. PMID 2843775.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leonard WJ, Donlon TA, Lebo RV, Greene WC (1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science. 228 (4707): 1547–9. PMID 3925551.CS1 maint: Multiple names: authors list (link)
• Bamborough P, Hedgecock CJ, Richards WG (1995). "The interleukin-2 and interleukin-4 receptors studied by molecular modelling". Structure. 2 (9): 839–51. PMID 7529123.CS1 maint: Multiple names: authors list (link)
• Minami Y, Nakagawa Y, Kawahara A; et al. (1995). "Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway". Immunity. 2 (1): 89–100. PMID 7600304.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giri JG, Kumaki S, Ahdieh M; et al. (1995). "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor". EMBO J. 14 (15): 3654–63. PMID 7641685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kirken RA, Rui H, Evans GA, Farrar WL (1993). "Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit". J. Biol. Chem. 268 (30): 22765–70. PMID 7693677.CS1 maint: Multiple names: authors list (link)
• Puri RK, Leland P, Aggarwal BB (1995). "Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line". AIDS Res. Hum. Retroviruses. 11 (1): 31–40. PMID 7734194.CS1 maint: Multiple names: authors list (link)
• Miyazaki T, Liu ZJ, Kawahara A; et al. (1995). "Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation". Cell. 81 (2): 223–31. PMID 7736574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.