IL1RL1
| Interleukin 1 receptor-like 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | IL1RL1 ; T1; ST2; DER4; FIT-1; MGC32623; ST2L; ST2V | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2862 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
 | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Interleukin 1 receptor-like 1, also known as IL1RL1, is a human gene.[1]
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.[1]
References
Further reading
- Tominaga S, Yokota T, Yanagisawa K; et al. (1993). "Nucleotide sequence of a complementary DNA for human ST2". Biochim. Biophys. Acta. 1171 (2): 215–8. PMID 1482686.
- Gayle MA, Slack JL, Bonnert TP; et al. (1996). "Cloning of a putative ligand for the T1/ST2 receptor". J. Biol. Chem. 271 (10): 5784–9. PMID 8621446.
- Yanagisawa K, Naito Y, Kuroiwa K; et al. (1997). "The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells". J. Biochem. 121 (1): 95–103. PMID 9058198.
- Kumar S, Tzimas MN, Griswold DE, Young PR (1997). "Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli". Biochem. Biophys. Res. Commun. 235 (3): 474–8. doi:10.1006/bbrc.1997.6810. PMID 9207179.
- Löhning M, Stroehmann A, Coyle AJ; et al. (1998). "T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6930–5. PMID 9618516.
- Moritz DR, Rodewald HR, Gheyselinck J, Klemenz R (1998). "The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors". J. Immunol. 161 (9): 4866–74. PMID 9794420.
- Saccani S, Polentarutti N, Penton-Rol G; et al. (1999). "Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo". Cytokine. 10 (10): 773–80. doi:10.1006/cyto.1998.0359. PMID 9811530.
- Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
- Iwahana H, Yanagisawa K, Ito-Kosaka A; et al. (1999). "Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells". Eur. J. Biochem. 264 (2): 397–406. PMID 10491084.
- Tominaga S, Kuroiwa K, Tago K; et al. (1999). "Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM". Biochem. Biophys. Res. Commun. 264 (1): 14–8. doi:10.1006/bbrc.1999.1469. PMID 10527832.
- Li H, Tago K, Io K; et al. (2000). "The cloning and nucleotide sequence of human ST2L cDNA". Genomics. 67 (3): 284–90. doi:10.1006/geno.2000.6269. PMID 10936050.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Sweet MJ, Leung BP, Kang D; et al. (2001). "A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression". J. Immunol. 166 (11): 6633–9. PMID 11359817.
- Tago K, Noda T, Hayakawa M; et al. (2001). "Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V". Biochem. Biophys. Res. Commun. 285 (5): 1377–83. doi:10.1006/bbrc.2001.5306. PMID 11478810.
- Lécart S, Lecointe N, Subramaniam A; et al. (2002). "Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface". Eur. J. Immunol. 32 (10): 2979–87. doi:10.1002/1521-4141(2002010)32:10<2979::AID-IMMU2979>3.0.CO;2-5. PMID 12355452.
- Brint EK, Fitzgerald KA, Smith P; et al. (2003). "Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction". J. Biol. Chem. 277 (51): 49205–11. doi:10.1074/jbc.M209685200. PMID 12368275.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Haga Y, Yanagisawa K, Ohto-Ozaki H; et al. (2003). "The effect of ST2 gene product on anchorage-independent growth of a glioblastoma cell line, T98G". Eur. J. Biochem. 270 (1): 163–70. PMID 12492487.
- Weinberg EO, Shimpo M, Hurwitz S; et al. (2003). "Identification of serum soluble ST2 receptor as a novel heart failure biomarker". Circulation. 107 (5): 721–6. PMID 12578875.
- Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |