IL1RAPL1

Interleukin 1 receptor accessory protein-like 1
PDB rendering based on 1t3g.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1t3g​
Identifiers
Symbols	IL1RAPL1 ; IL1R8; IL1RAPL; MRX21; MRX34; OPHN4; TIGIRR-2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8609
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Interleukin 1 receptor accessory protein-like 1, also known as IL1RAPL1, is a human gene.

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.

Further reading

• Kozák L, Chiurazzi P, Genuardi M; et al. (1993). "Mapping of a gene for non-specific X linked mental retardation: evidence for linkage to chromosomal region Xp21.1-Xp22.3". J. Med. Genet. 30 (10): 866–9. PMID 8230164.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tranebjaerg L, Lubs HA, Borghgraef M; et al. (1996). "Seventh International Workshop on the Fragile X and X-linked Mental Retardation". Am. J. Med. Genet. 64 (1): 1–14. doi:10.1002/(SICI)1096-8628(19960712)64:1<1::AID-AJMG1>3.0.CO;2-Z. PMID 8826442.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu C, Chalmers D, Maki R, De Souza EB (1996). "Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies". J. Neuroimmunol. 66 (1–2): 41–8. PMID 8964912.CS1 maint: Multiple names: authors list (link)
• Carrié A, Jun L, Bienvenu T; et al. (1999). "A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation". Nat. Genet. 23 (1): 25–31. doi:10.1038/12623. PMID 10471494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin H, Gardner RJ, Viswesvaraiah R; et al. (2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation". Eur. J. Hum. Genet. 8 (2): 87–94. doi:10.1038/sj.ejhg.5200415. PMID 10757639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Born TL, Smith DE, Garka KE; et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitano T, Schwarz C, Nickel B, Pääbo S (2004). "Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees". Mol. Biol. Evol. 20 (8): 1281–9. doi:10.1093/molbev/msg134. PMID 12777533.CS1 maint: Multiple names: authors list (link)
• Bahi N, Friocourt G, Carrié A; et al. (2004). "IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis". Hum. Mol. Genet. 12 (12): 1415–25. PMID 12783849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Khan JA, Brint EK, O'Neill LA, Tong L (2004). "Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL". J. Biol. Chem. 279 (30): 31664–70. doi:10.1074/jbc.M403434200. PMID 15123616.CS1 maint: Multiple names: authors list (link)
• Zhang YH, Huang BL, Niakan KK; et al. (2005). "IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1". Hum. Mutat. 24 (3): 273. doi:10.1002/humu.9269. PMID 15300857.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tabolacci E, Pomponi MG, Pietrobono R; et al. (2006). "A truncating mutation in the IL1RAPL1 gene is responsible for X-linked mental retardation in the MRX21 family". Am. J. Med. Genet. A. 140 (5): 482–7. doi:10.1002/ajmg.a.31107. PMID 16470793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)