IFNAR1
| Interferon (alpha, beta and omega) receptor 1 | |||||||||||
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| Symbols | IFNAR1 ; AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 524 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Interferon (alpha, beta and omega) receptor 1, also known as IFNAR1, is a human gene.[1]
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.[1]
References
Further reading
- Bürglin TR, Barnes TM (1992). "Introns in sequence tags". Nature. 357 (6377): 367–8. doi:10.1038/357367a0. PMID 1350660.
- Lutfalla G, Gardiner K, Proudhon D; et al. (1992). "The structure of the human interferon alpha/beta receptor gene". J. Biol. Chem. 267 (4): 2802–9. PMID 1370833.
- Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641.
- Lutfalla G, Roeckel N, Mogensen KE; et al. (1991). "Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization". J. Interferon Res. 10 (5): 515–7. PMID 2148760.
- Uzé G, Lutfalla G, Gresser I (1990). "Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA". Cell. 60 (2): 225–34. PMID 2153461.
- Colamonici O, Yan H, Domanski P; et al. (1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase". Mol. Cell. Biol. 14 (12): 8133–42. PMID 7526154.
- Uddin S, Chamdin A, Platanias LC (1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". J. Biol. Chem. 270 (42): 24627–30. PMID 7559568.
- Domanski P, Witte M, Kellum M; et al. (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling". J. Biol. Chem. 270 (37): 21606–11. PMID 7665574.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Novick D, Cohen B, Rubinstein M (1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell. 77 (3): 391–400. PMID 8181059.
- Yan H, Krishnan K, Greenlund AC; et al. (1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". EMBO J. 15 (5): 1064–74. PMID 8605876.
- Yang CH, Shi W, Basu L; et al. (1996). "Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor". J. Biol. Chem. 271 (14): 8057–61. PMID 8626489.
- Abramovich C, Yakobson B, Chebath J, Revel M (1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor". EMBO J. 16 (2): 260–6. doi:10.1093/emboj/16.2.260. PMID 9029147.
- Eantuzzi L, Eid P, Malorni W; et al. (1997). "Post-translational up-regulation of the cell surface-associated alpha component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon". Eur. J. Immunol. 27 (5): 1075–81. PMID 9174595.
- Gessani S, Borghi P, Fantuzzi L; et al. (1997). "Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation". J. Leukoc. Biol. 62 (1): 49–53. PMID 9225992.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Krishnan K, Singh B, Krolewski JJ (1998). "Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor". J. Biol. Chem. 273 (31): 19495–501. PMID 9677371.
- Richter MF, Duménil G, Uzé G; et al. (1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1". J. Biol. Chem. 273 (38): 24723–9. PMID 9733772.
- Rani MR, Leaman DW, Han Y; et al. (1999). "Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase". J. Biol. Chem. 274 (45): 32507–11. PMID 10542297.
- Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.