ICMT

Isoprenylcysteine carboxyl methyltransferase
Identifiers
Symbols	ICMT ; HSTE14; MGC39955; MST098; MSTP098; PCCMT; PCMT; PPMT
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5735
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Isoprenylcysteine carboxyl methyltransferase, also known as ICMT, is a human gene.

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Further reading

• Dai Q, Choy E, Chiu V; et al. (1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum". J. Biol. Chem. 273 (24): 15030–4. PMID 9614111.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Choy E, Chiu VK, Silletti J; et al. (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi". Cell. 98 (1): 69–80. doi:10.1016/S0092-8674(00)80607-8. PMID 10412982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Desrosiers RR, Nguyen QT, Béliveau R (1999). "The carboxyl methyltransferase modifying G proteins is a metalloenzyme". Biochem. Biophys. Res. Commun. 261 (3): 790–7. doi:10.1006/bbrc.1999.0936. PMID 10441503.CS1 maint: Multiple names: authors list (link)
• Lin X, Antalffy B, Kang D; et al. (2000). "Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1". Nat. Neurosci. 3 (2): 157–63. doi:10.1038/72101. PMID 10649571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van Dessel GA, De Busser HM, Lagrou AR (2002). "Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells". Int. J. Biochem. Cell Biol. 34 (5): 477–86. PMID 11906819.CS1 maint: Multiple names: authors list (link)
• Ahmad M, Zhang Y, Zhang Y; et al. (2002). "Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells". Arterioscler. Thromb. Vasc. Biol. 22 (5): 759–64. PMID 12006387.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kramer K, Harrington EO, Lu Q; et al. (2004). "Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis". Mol. Biol. Cell. 14 (3): 848–57. doi:10.1091/mbc.E02-07-0390. PMID 12631708.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winter-Vann AM, Kamen BA, Bergo MO; et al. (2003). "Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6529–34. doi:10.1073/pnas.1135239100. PMID 12750467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergo MO, Gavino BJ, Hong C; et al. (2004). "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf". J. Clin. Invest. 113 (4): 539–50. doi:10.1172/JCI200418829. PMID 14966563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu Q, Harrington EO, Newton J; et al. (2007). "Inhibition of ICMT induces endothelial cell apoptosis through GRP94". Am. J. Respir. Cell Mol. Biol. 37 (1): 20–30. doi:10.1165/rcmb.2006-0301SM. PMID 17347446.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)