IC-26

IC-26
Identifiers
	IUPAC name 4-ethylsulfonyl-N,N-dimethyl-4,4-di(phenyl)butan-2-amine;
PubChem CID	113832;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C20H27NO2S
Molar mass	345.499
3D model (JSmol)	Interactive image;
	SMILES CCS(=O)(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2;

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

IC-26 (WIN 1161-3) is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group.

Human and animal studies suggest that IC-26 is around the same potency as methadone,^[1]^[2] although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potantial, but despite being found to have similar potential to methadone for development of dependence^[3] it was never placed under international control as an illegal drug.

References

↑ Daniel Lednicer. Central Analgetics. (1982), p194. ISBN 0-471-08314-3
↑ Paul A J Janssen. Synthetic Analgesics Part 1: Diphenylpropylamines. Pergamon Press 1960. p161-163.
↑ Wolbach AB, Fraser HF. Addiction Liability of I-C-26. UNODC Bulletin on Narcotics 1963 Vol 1

Template:Opioids

Template:WikiDoc Sources

[1] Daniel Lednicer. Central Analgetics. (1982), p194. ISBN 0-471-08314-3

[2] Paul A J Janssen. Synthetic Analgesics Part 1: Diphenylpropylamines. Pergamon Press 1960. p161-163.

[3] Wolbach AB, Fraser HF. Addiction Liability of I-C-26. UNODC Bulletin on Narcotics 1963 Vol 1

[1]

[2]

[3]

Identifiers

IUPAC name 4-ethylsulfonyl-N,N-dimethyl-4,4-di(phenyl)butan-2-amine
PubChem CID	113832
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₀H₂₇NO₂S
Molar mass	345.499
3D model (JSmol)	Interactive image
SMILES CCS(=O)(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

IC-26

Overview

References

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