IC-26
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Identifiers | |
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PubChem CID | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C20H27NO2S |
Molar mass | 345.499 |
3D model (JSmol) | |
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IC-26 (WIN 1161-3) is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group.
Human and animal studies suggest that IC-26 is around the same potency as methadone,[1][2] although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potantial, but despite being found to have similar potential to methadone for development of dependence[3] it was never placed under international control as an illegal drug.
References
- ↑ Daniel Lednicer. Central Analgetics. (1982), p194. ISBN 0-471-08314-3
- ↑ Paul A J Janssen. Synthetic Analgesics Part 1: Diphenylpropylamines. Pergamon Press 1960. p161-163.
- ↑ Wolbach AB, Fraser HF. Addiction Liability of I-C-26. UNODC Bulletin on Narcotics 1963 Vol 1
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