IκB kinase
| conserved helix-loop-helix ubiquitous kinase | |
|---|---|
| Identifiers | |
| Symbol | CHUK |
| Alt. symbols | TCF16 |
| Entrez | 1147 |
| HUGO | 1974 |
| OMIM | 600664 |
| RefSeq | NM_001278 |
| UniProt | O15111 |
| Other data | |
| EC number | 2.7.11.10 |
| Locus | Chr. 10 q24-q25 |
| inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | |
|---|---|
| Identifiers | |
| Symbol | IKBKB |
| Entrez | 3551 |
| HUGO | 5960 |
| OMIM | 603258 |
| RefSeq | NM_001556 |
| UniProt | O14920 |
| Other data | |
| EC number | 2.7.11.10 |
| Locus | Chr. 8 p11.2 |
| inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | |
|---|---|
| Identifiers | |
| Symbol | IKBKG |
| Alt. symbols | IP2, IP1 |
| Entrez | 8517 |
| HUGO | 5961 |
| OMIM | 300248 |
| RefSeq | NM_003639 |
| UniProt | Q9Y6K9 |
| Other data | |
| Locus | Chr. X q28 |
Overview
The IκB kinase (IKK) enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keep them sequestered in an inactive state in the cytoplasm.[1][2][3] IKK specifically phosphorylates the inhibitory IκBα protein.[4] This phosphorylation results in the dissociation of IκBα from NF-κB and thereby activates NF-κB.
Structure
The IκB kinase complex is comprised of three subunits each encoded by a separate gene:
- IKKα (also known as IKK1) (CHUK)
- IKKβ (also known as IKK2) (IKBKB)
- IKKγ (also known as NEMO) (IKBKG)
The α- and β-subunits together are catalytically active whereas the γ-subunit serves a regulatory function.
References
- ↑ Jacobs MD, Harrison SC (1998). "Structure of an IkappaBalpha/NF-kappaB complex". Cell. 95 (6): 749–58. doi:10.1016/S0092-8674(00)81698-0. PMID 9865693.
- ↑ Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M (1997). "Identification and characterization of an IkappaB kinase". Cell. 90 (2): 373–83. doi:10.1016/S0092-8674(00)80344-X. PMID 9244310.
- ↑ Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A (1997). "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation". Science. 278 (5339): 860–6. doi:10.1126/science.278.5339.860. PMID 9346484.
- ↑ Karin M (1999). "How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex". Oncogene. 18 (49): 6867–74. doi:10.1038/sj.onc.1203219. PMID 10602462.
External links
- I-kappa+B+Kinase at the US National Library of Medicine Medical Subject Headings (MeSH)