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===Discovery===
===Discovery===
*[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
The historical perspective of hypernatremia is as follows:<ref>{{Cite journal


*The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
| author = [[J. Barcroft]] & [[H. Straub]]
*In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
 
*In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
| title = The secretion of urine
 
| journal = [[The Journal of physiology]]
 
| volume = 41
 
| issue = 3-4
 
| pages = 145–167
 
| year = 1910
 
| month = November
 
| pmid = 16993045
 
}}</ref><ref>{{cite book | last = Czerny | first = A | title = Ergebnisse der Inneren Medizin und Kinderheilkunde : Achtundvierzigster Band | publisher = Springer Berlin Heidelberg | location = Berlin, Heidelberg | year = 1935 | isbn = 9783642906701 }}</ref><ref>{{Cite journal
 
| author = [[J. P. PETERS]], [[L. G. WELT]], [[E. A. H. SIMS]], [[J. ORLOFF]] & [[J. NEEDHAM]]
 
| title = A salt-wasting syndrome associated with cerebral disease
 
| journal = [[Transactions of the Association of American Physicians]]
 
| volume = 63
 
| pages = 57–64
 
| year = 1950
 
| month =
 
| pmid = 14855556
 
}}</ref><ref>{{Cite journal
 
| author = [[L. G. WELT]], [[D. W. SELDIN]], [[W. P. NELSON]], [[W. J. GERMAN]] & [[J. P. PETERS]]
 
| title = Role of the central nervous system in metabolism of electrolytes and water
 
| journal = [[A.M.A. archives of internal medicine]]
 
| volume = 90
 
| issue = 3
 
| pages = 355–378
 
| year = 1952
 
| month = September
 
| pmid = 14952060
 
}}</ref>
===Discovery===
* In 1858, Claude Bernard, French physiologist first proposed a direct relationship between the [[central  nervous system]] and renal excretion of osmotically active [[solutes]].
* In 1913, Jungmann and Meyer in Germany induced [[polyuria]] and increased urinary salt excretion in animals through [[medullary]] lesion.
* in 1950, Peters, Welt, and co-workers described few patients with [[encephalitis]], hypertensive [[intracranial hemorrhage]], and bulbar [[poliomyelitis]] who presented with  severe [[dehydration]] and [[hyponatremia]].
 
* In 1952, Welt and colleagues presented patients with cerebral lesions (including trauma, tumor, and infection)  and severe hypernatremia with clinical dehydration but no potassium retention.


==Outbreaks==
==Outbreaks==

Revision as of 17:12, 21 May 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2]

Overview

Historical Perspective

Discovery

The historical perspective of hypernatremia is as follows:[1][2][3][4]

Discovery

  • In 1952, Welt and colleagues presented patients with cerebral lesions (including trauma, tumor, and infection) and severe hypernatremia with clinical dehydration but no potassium retention.

Outbreaks

  • There have been several outbreaks of [disease name], which are summarized below:

Landmark Events in the Development of Treatment Strategies

  • In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

Impact on Cultural History

Famous Cases

References

  1. J. Barcroft & H. Straub (1910). "The secretion of urine". The Journal of physiology. 41 (3–4): 145–167. PMID 16993045. Unknown parameter |month= ignored (help)
  2. Czerny, A (1935). Ergebnisse der Inneren Medizin und Kinderheilkunde : Achtundvierzigster Band. Berlin, Heidelberg: Springer Berlin Heidelberg. ISBN 9783642906701.
  3. J. P. PETERS, L. G. WELT, E. A. H. SIMS, J. ORLOFF & J. NEEDHAM (1950). "A salt-wasting syndrome associated with cerebral disease". Transactions of the Association of American Physicians. 63: 57–64. PMID 14855556.
  4. L. G. WELT, D. W. SELDIN, W. P. NELSON, W. J. GERMAN & J. P. PETERS (1952). "Role of the central nervous system in metabolism of electrolytes and water". A.M.A. archives of internal medicine. 90 (3): 355–378. PMID 14952060. Unknown parameter |month= ignored (help)

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