Revision as of 21:08, 2 March 2016 by YazanDaaboul (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

WikiDoc Resources for Hypergammaglobulinemia


Most recent articles on Hypergammaglobulinemia

Most cited articles on Hypergammaglobulinemia

Review articles on Hypergammaglobulinemia

Articles on Hypergammaglobulinemia in N Eng J Med, Lancet, BMJ


Powerpoint slides on Hypergammaglobulinemia

Images of Hypergammaglobulinemia

Photos of Hypergammaglobulinemia

Podcasts & MP3s on Hypergammaglobulinemia

Videos on Hypergammaglobulinemia

Evidence Based Medicine

Cochrane Collaboration on Hypergammaglobulinemia

Bandolier on Hypergammaglobulinemia

TRIP on Hypergammaglobulinemia

Clinical Trials

Ongoing Trials on Hypergammaglobulinemia at Clinical Trials.gov

Trial results on Hypergammaglobulinemia

Clinical Trials on Hypergammaglobulinemia at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Hypergammaglobulinemia

NICE Guidance on Hypergammaglobulinemia


FDA on Hypergammaglobulinemia

CDC on Hypergammaglobulinemia


Books on Hypergammaglobulinemia


Hypergammaglobulinemia in the news

Be alerted to news on Hypergammaglobulinemia

News trends on Hypergammaglobulinemia


Blogs on Hypergammaglobulinemia


Definitions of Hypergammaglobulinemia

Patient Resources / Community

Patient resources on Hypergammaglobulinemia

Discussion groups on Hypergammaglobulinemia

Patient Handouts on Hypergammaglobulinemia

Directions to Hospitals Treating Hypergammaglobulinemia

Risk calculators and risk factors for Hypergammaglobulinemia

Healthcare Provider Resources

Symptoms of Hypergammaglobulinemia

Causes & Risk Factors for Hypergammaglobulinemia

Diagnostic studies for Hypergammaglobulinemia

Treatment of Hypergammaglobulinemia

Continuing Medical Education (CME)

CME Programs on Hypergammaglobulinemia


Hypergammaglobulinemia en Espanol

Hypergammaglobulinemia en Francais


Hypergammaglobulinemia in the Marketplace

Patents on Hypergammaglobulinemia

Experimental / Informatics

List of terms related to Hypergammaglobulinemia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Synonyms and keywords: Hyper IgM syndrome; Hyper IgD syndrome; Hyper IgE syndrome; HIES; Job syndrome; Buckley syndrome


Hypergammaglobulinemia is a primary immunodeficiency disease with an elevated concentration of gamma globulins (immunoglobulins or antibodies).[1][2][3] The term "hypergammaglobulinemia" refers to the position of the excess of proteins after serum protein electrophoresis (found in the gammaglobulin region).[1] The majority of hypergammaglobulinemias are due to an excess of immunoglobulin M (IgM) because this is the default immunoglobulin type prior to class switching.[1] Hypergammaglobulinemias may also result from a deficiency in the other major types of immunoglobulins (IgA, IgE, and IgG).[1][4]


  • Hypergammaglobulinemia may be classified into the following:
  • Hyper IgM associated hypergammaglobulinemias are further classified into the following five types:[5][6]
Type Gene involved Mode of inheritance

Type 1

  • Tumor Necrosis Factor Super Family member 5 (TNFSF5) gene encoding CD40L

X-linked recessive

Type 2

  • Activation-Induced Cytidine Deaminase (AICDA) gene

Autosomal recessive

Type 3

  • CD40 gene

Autosomal recessive

Type 4

  • Not yet known

Type 5

  • Gene encoding Uracil-DNA glycosylase

Autosomal recessive


  1. 1.0 1.1 1.2 1.3 Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.
  2. Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.
  3. Primary immunodeficiency. Wikipedia. https://en.wikipedia.org/wiki/Primary_immunodeficiency Accessed on March 2, 2016.
  4. Immunoproliferative disorder. Wikipedia. Accessed on February 24, 2016.
  5. Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016
  6. Immunodeficiency with hyper-IgM, Type 1; HIGM1. http://www.omim.org/entry/308230. Accessed on February 24, 2016

Related Chapters

Template:WikiDoc Sources