Hydrocephalus obesity hypogonadism

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S

Synonyms and keywords: Sengers-Hamel-Otten syndrome

Overview

This syndrome is characterized by the association of

• Congenital hydrocephalus
• Centripetal obesity
• Hypogonadism
• Intellectual deficit and
• Short stature

Pathophysiology

Genetics

An X-linked recessive mode of inheritance was suggested.

Epidemiology and Demographics

It has been described in two males from one family.