Human papillomavirus screening

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S [2]

Overview

High-risk HPV types are associated with 70% of cervical cancers in females having persistent infection.^[1] Due to this strong association between HPV and cervical cancer, cervical cancer screening is recommended in all females from age 21. According to the US Preventive Services Task Force (USPSTF), specific screening guidelines for cervical cancer includes screening all females from age 21 to 65 for cervical cancer.^[2]^[3]

High-risk HPV types are associated with 70% of cervical cancers in females having persistent infection.^[1] Due to this strong association between HPV and cervical cancer, cervical cancer screening is recommended in all females from age 21. According to the US Preventive Services Task Force (USPSTF), specific screening guidelines for cervical cancer is described below:^[2]^[3]^[4]


Population	Recommendations
Women 21 to 65 (pap Smear)	Screen every 3 years Cytology with pap smear Grade A recommendation
Women aged 30-65	Screen every 3 years (cytology with pap smear) Screen every 5 years (pap smear with HPV testing)^[5] Grade A recommendation
Women younger than 21	Do not screen Grade D recommendation
Women older than 65 (who have had adequate prior screening)	Do not screen Grade D recommendation
Women after hysterectomy with removal of cervix (no h/o high grade precancer or cervical cancer)	Do not screen Grade D recommendation
Women before age 30	Do not screen with HPV testing Grade D recommendation

↑ ^1.0 ^1.1 http://www.cdc.gov/vaccines/pubs/pinkbook/hpv.html#epi Accessed on October 13, 2016
↑ ^2.0 ^2.1 Moyer VA, U.S. Preventive Services Task Force (2012). "Screening for cervical cancer: U.S. Preventive Services Task Force recommendation statement". Ann Intern Med. 156 (12): 880–91, W312. doi:10.7326/0003-4819-156-12-201206190-00424. PMID 22711081.
↑ ^3.0 ^3.1 McGraw SL, Ferrante JM (2014). "Update on prevention and screening of cervical cancer". World J Clin Oncol. 5 (4): 744–52. doi:10.5306/wjco.v5.i4.744. PMC 4129537. PMID 25302174.
↑ Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I; et al. (2021). "Sexually Transmitted Infections Treatment Guidelines, 2021". MMWR Recomm Rep. 70 (4): 1–187. doi:10.15585/mmwr.rr7004a1. PMC 8344968 Check |pmc= value (help). PMID 34292926 Check |pmid= value (help).
↑ Datta SD, Koutsky LA, Ratelle S, Unger ER, Shlay J, McClain T; et al. (2008). "Human papillomavirus infection and cervical cytology in women screened for cervical cancer in the United States, 2003-2005". Ann Intern Med. 148 (7): 493–500. PMID 18378945 PMID: 18378945 Check |pmid= value (help).