Hospital-acquired pneumonia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Hospital-acquired pneumonia from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic criteria

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

Treatment

Medical Therapy

Prevention

Clinical Features

Pneumonia as seen on chest x-ray. A: Normal chest x-ray. B: Abnormal chest x-ray with shadowing from pneumonia in the right lung (left side of image).

New or progressive infiltrate on the chest X-Ray with one of the following:[1]

Diagnosis

In hospitalised patient who develop respiratory symptoms and fever one should consider the diagnosis. The likelyhood increases when upon investigation symptoms are found of respiratory insufficiency, purulent secretions, newly developed infiltrate on the chest X-Ray, and increasing leucocyte count. If pneumonia is suspected material from sputum or tracheal aspirates are sent to the microbiology department for cultures. In case of pleural effusion thoracentesis is performed for examination of pleural fluid. In suspected ventilator-associated pneumonia it has been suggested that bronchoscopy(BAL) is necessary because of the known risks surrounding clinical diagnoses.[2][1]

Diagnostic criteria of hospital acquired pneumonia

Community acquired pneumonia should be distinguished from healthcare-associated pneumonia as these diseases have different causative organism, prognosis, diagnostic and treatment guidelines. According to the Infectious Diseases Society of America and the American Thoracic Society healthcare-associated pneumonia includes any patient who meet the below criteria [3]

  • Hospitalized in an acute care hospital for 2 or more days within 90 days of the infection;
  • Resided in a nursing home or long-term care facility;
  • Received recent intravenous antibiotic therapy, chemotherapy, or wound care within the past 30 days of the current infection;
  • Attended a hospital or hemodialysis clinic

Differential diagnosis

Treatment

Usually initial therapy is empirical.[1] If sufficient reason to suspect influenza one might consider amantadine or rimantadine. In case of legionellosis erythromicin or fluoroquinolone.[2]

A third generation cephalosporin (ceftazidime) + carbapenems (imipenem) + beta lactam & beta lactamase inhibitors (piperacillin/tazobactum)

References

  1. 1.0 1.1 1.2
  2. 2.0 2.1
  3. Attridge RT, Frei CR (2011). "Health care-associated pneumonia: an evidence-based review". The American Journal of Medicine. 124 (8): 689–97. doi:10.1016/j.amjmed.2011.01.023. PMID 21663884. Retrieved 2012-09-02. Unknown parameter |month= ignored (help)

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