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Homeobox A10 - Revision history
2024-03-29T05:35:21Z
Revision history for this page on the wiki
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imported>DeepakNModi: /* Further reading */
2018-07-16T15:57:34Z
<p><span dir="auto"><span class="autocomment">Further reading</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:57, 16 July 2018</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez" /></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez" /></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Downregualtion of HOXA10 is observed in the human and [[baboon]] decidua after implantation and this downregulation promotes [[trophoblast]] invasion by activating [[STAT3]]<ref>{{cite journal |last1=Godbole |first1=Geeta |last2=Suman |first2=Pankaj |last3=Malik |first3=Ankita |last4=Galvankar |first4=Mosami |last5=Joshi |first5=Niraj |last6=Fazleabas |first6=Asgi |last7=Gupta |first7=Satish |last8=Modi |first8=Deepak |title=Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion. |journal=Endocrinology |volume=158 |issue=8 |page=2618-2633 |doi=10.1210/en.2017-00032 |pmid=28520923}}</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Interactions ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Interactions ==</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{refend}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{refend}}</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><ref>{{cite journal |last1=Godbole |first1=Geeta |last2=Modi |first2=Deepak |title=Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox A 10 in endometrial stromal cells. |journal=American Journal of Reproductive Immunology |volume=85 |issue=2 |page=130-139 |doi=10.1016/j.jri.2010.03.003 |pmid=20478621 |url=https://www.sciencedirect.com/science/article/pii/S0165037810000690?via%3Dihub}}</ref><ref>{{cite journal |last1=Godbole |first1=Geeta |last2=Puri |first2=CP |last3=Modi |first3=Deepak |title=Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli. |journal=Reproduction |volume=134 |issue=3 |page=513-523 |doi=10.1530/REP-07-0234 |pmid=17709569 |url=http://www.reproduction-online.org/content/134/3/513.long}}</ref></ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== External links ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== External links ==</div></td></tr>
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WikiBot: Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
2012-09-04T18:18:59Z
<p>Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})</p>
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{{GNF_Protein_box<br />
| image = <br />
| image_source = <br />
| PDB = <br />
| Name = Homeobox A10<br />
| HGNCid = 5100<br />
| Symbol = HOXA10<br />
| AltSymbols =; PL; HOX1; HOX1.8; HOX1H; MGC12859<br />
| OMIM = 142957<br />
| ECnumber = <br />
| Homologene = 7365<br />
| MGIid = 96171<br />
| GeneAtlas_image1 = PBB_GE_HOXA10_213150_at_tn.png<br />
| GeneAtlas_image2 = PBB_GE_HOXA10_213147_at_tn.png<br />
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} <br />
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} <br />
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} <br />
| Orthologs = {{GNF_Ortholog_box<br />
| Hs_EntrezGene = 3206<br />
| Hs_Ensembl = ENSG00000153807<br />
| Hs_RefseqProtein = NP_061824<br />
| Hs_RefseqmRNA = NM_018951<br />
| Hs_GenLoc_db = <br />
| Hs_GenLoc_chr = 7<br />
| Hs_GenLoc_start = 27177382<br />
| Hs_GenLoc_end = 27180399<br />
| Hs_Uniprot = P31260<br />
| Mm_EntrezGene = 15395<br />
| Mm_Ensembl = ENSMUSG00000000938<br />
| Mm_RefseqmRNA = NM_008263<br />
| Mm_RefseqProtein = NP_032289<br />
| Mm_GenLoc_db = <br />
| Mm_GenLoc_chr = 6<br />
| Mm_GenLoc_start = 52160780<br />
| Mm_GenLoc_end = 52164522<br />
| Mm_Uniprot = P31310<br />
}}<br />
}}<br />
'''Homeobox A10''', also known as '''HOXA10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXA10 homeobox A10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206| accessdate = }}</ref><br />
<br />
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --><br />
{{PBB_Summary<br />
| section_title = <br />
| summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: HOXA10 homeobox A10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206| accessdate = }}</ref><br />
}}<br />
<br />
==See also==<br />
* [[Homeobox]]<br />
<br />
==References==<br />
{{reflist|2}}<br />
<br />
==Further reading==<br />
{{refbegin | 2}}<br />
{{PBB_Further_reading <br />
| citations = <br />
*{{cite journal | author=Eun Kwon H, Taylor HS |title=The role of HOX genes in human implantation. |journal=Ann. N. Y. Acad. Sci. |volume=1034 |issue= |pages= 1-18 |year= 2005 |pmid= 15731295 |doi= 10.1196/annals.1335.001 }}<br />
*{{cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi= }}<br />
*{{cite journal | author=Lowney P, Corral J, Detmer K, ''et al.'' |title=A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells. |journal=Nucleic Acids Res. |volume=19 |issue= 12 |pages= 3443-9 |year= 1991 |pmid= 1676505 |doi= }}<br />
*{{cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi= }}<br />
*{{cite journal | author=Shen WF, Largman C, Lowney P, ''et al.'' |title=Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 21 |pages= 8536-40 |year= 1989 |pmid= 2573064 |doi= }}<br />
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}<br />
*{{cite journal | author=Sauvageau G, Lansdorp PM, Eaves CJ, ''et al.'' |title=Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 25 |pages= 12223-7 |year= 1995 |pmid= 7527557 |doi= }}<br />
*{{cite journal | author=Lawrence HJ, Sauvageau G, Ahmadi N, ''et al.'' |title=Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. |journal=Exp. Hematol. |volume=23 |issue= 11 |pages= 1160-6 |year= 1995 |pmid= 7556525 |doi= }}<br />
*{{cite journal | author=Satokata I, Benson G, Maas R |title=Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. |journal=Nature |volume=374 |issue= 6521 |pages= 460-3 |year= 1995 |pmid= 7700356 |doi= 10.1038/374460a0 }}<br />
*{{cite journal | author=Castronovo V, Kusaka M, Chariot A, ''et al.'' |title=Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. |journal=Biochem. Pharmacol. |volume=47 |issue= 1 |pages= 137-43 |year= 1994 |pmid= 7906121 |doi= }}<br />
*{{cite journal | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi= }}<br />
*{{cite journal | author=Thorsteinsdottir U, Sauvageau G, Hough MR, ''et al.'' |title=Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. |journal=Mol. Cell. Biol. |volume=17 |issue= 1 |pages= 495-505 |year= 1997 |pmid= 8972230 |doi= }}<br />
*{{cite journal | author=Shen WF, Montgomery JC, Rozenfeld S, ''et al.'' |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448-58 |year= 1997 |pmid= 9343407 |doi= }}<br />
*{{cite journal | author=Taylor HS, Vanden Heuvel GB, Igarashi P |title=A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. |journal=Biol. Reprod. |volume=57 |issue= 6 |pages= 1338-45 |year= 1998 |pmid= 9408238 |doi= }}<br />
*{{cite journal | author=Taylor HS, Arici A, Olive D, Igarashi P |title=HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. |journal=J. Clin. Invest. |volume=101 |issue= 7 |pages= 1379-84 |year= 1998 |pmid= 9525980 |doi= }}<br />
*{{cite journal | author=Kawagoe H, Humphries RK, Blair A, ''et al.'' |title=Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. |journal=Leukemia |volume=13 |issue= 5 |pages= 687-98 |year= 1999 |pmid= 10374871 |doi= }}<br />
*{{cite journal | author=Eklund EA, Jalava A, Kakar R |title=Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20117-26 |year= 2000 |pmid= 10766757 |doi= 10.1074/jbc.M907915199 }}<br />
*{{cite journal | author=Buske C, Feuring-Buske M, Antonchuk J, ''et al.'' |title=Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. |journal=Blood |volume=97 |issue= 8 |pages= 2286-92 |year= 2001 |pmid= 11290589 |doi= }}<br />
*{{cite journal | author=Cermik D, Karaca M, Taylor HS |title=HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 7 |pages= 3387-92 |year= 2001 |pmid= 11443215 |doi= }}<br />
*{{cite journal | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509-22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001 }}<br />
}}<br />
{{refend}}<br />
<br />
== External links ==<br />
* {{MeshName|HOXA10+protein,+human}}<br />
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{{Transcription factors}}<br />
[[Category:Transcription factors]]<br />
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