|
|
| Line 1: |
Line 1: |
| __NOTOC__
| |
| {{SI}}
| |
| '''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
| |
|
| |
|
| '''For full discussion on Pancreatitis click [[Pancreatitis|here]].'''
| |
| {{CMG}}
| |
| ==Overview==
| |
| '''Hereditary Pancreatitis''' is a genetic disease affecting enzyme production in the pancreas.
| |
| ==Pathophysiology==
| |
| In the pancreas, a genetic mutation causes the enzyme [[trypsinogen]] to be made in a way which renders it resistant to inactivation through [[autolysis]]. Normally this autolysis mechanism prevents trypsinogen from being activated within the pancreas. However, when the abnormal trypsinogen is activated, it causes a chain reaction where all the trypsinogen in the pancreas is activated, effectively digesting the pancreas from the inside.
| |
|
| |
| ==Epidemiology and Demographics==
| |
| ===Prevalence===
| |
| Most estimates place the number of individuals with hereditary pancreatitis in the United States at 1000.
| |
| ==Diagnosis==
| |
| ===History and Symptoms===
| |
| Symptoms are generally the same as [[acute pancreatitis]], including
| |
| * Severe [[abdominal pain]]
| |
| * [[Vomiting]]
| |
| * [[Diarrhea]]
| |
| ==Treatment==
| |
|
| |
| ===Medical Therapy===
| |
| There is no treatment for the disease, although complications such as malnutrition can be treated with supplimentary pancreatic enzymes.
| |
|
| |
| ==References==
| |
| {{reflist|2}}
| |
|
| |
| {{Gastroenterology}}
| |
|
| |
| [[Category:Gastroenterology]]
| |
| [[Category:Genetic disorders]]
| |
|
| |
| [[Category:Disease]]
| |
|
| |
| {{WikiDoc Help Menu}}
| |
| {{WikiDoc Sources}}
| |
| '''Bold text'''
| |