Heptabarbital

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Heptabarbital
Clinical data
Synonyms	G-475
Pregnancy; category	?;
Routes of; administration	Oral
ATC code	N05CA11 (WHO) ;
Legal status
Legal status	?;
Pharmacokinetic data
Bioavailability	83%
Metabolism	Hepatic
Elimination half-life	6.1-11.2 hours
Excretion	Renal
Identifiers
	IUPAC name 5-cyclohept-1-en-1-yl-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione;
CAS Number	509-86-4;
PubChem CID	10518;
DrugBank	DB01354 ;
ChemSpider	10081 ;
UNII	V10R70ML23;
KEGG	C17725 ;
ChEMBL	ChEMBL468837 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C13H18N2O3
Molar mass	250.294 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=O)NC(=O)C1(/C2=C/CCCCC2)CC;
	InChI InChI=1S/C13H18N2O3/c1-2-13(9-7-5-3-4-6-8-9)10(16)14-12(18)15-11(13)17/h7H,2-6,8H2,1H3,(H2,14,15,16,17,18) ; Key:PAZQYDJGLKSCSI-UHFFFAOYSA-N ;
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Heptabarb (INN; Eudan, Medapan, Medomin, Noctyn), also known as heptabarbitone (BAN) or heptabarbital, is a sedative and hypnotic drug of the barbiturate family.^[2]^[3] It was previously used in Europe for the treatment of insomnia from the 1950s onwards, but has since been discontinued.^[2]^[3]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Breimer DD, de Boer AG (December 1975). "Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man". European Journal of Clinical Pharmacology. 9 (2–3): 169–78. doi:10.1007/bf00614014. PMID 9299.
↑ ^2.0 ^2.1 C. R Ganellin; D. J Triggle; F.. Macdonald (1997). Dictionary of pharmacological agents. CRC Press. p. 1003. ISBN 978-0-412-46630-4. Retrieved 26 November 2011.
↑ ^3.0 ^3.1 Index nominum 2000: international drug directory. Taylor & Francis US. 2000. p. 513. ISBN 978-3-88763-075-1. Retrieved 26 November 2011.

Template:GABAAR PAMs

Template:Sedative-stub

[pmid9299-1] 1.0 ^1.1 ^1.2 ^1.3 Breimer DD, de Boer AG (December 1975). "Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man". European Journal of Clinical Pharmacology. 9 (2–3): 169–78. doi:10.1007/bf00614014. PMID 9299.

[GanellinTriggle1997-2] 2.0 ^2.1 C. R Ganellin; D. J Triggle; F.. Macdonald (1997). Dictionary of pharmacological agents. CRC Press. p. 1003. ISBN 978-0-412-46630-4. Retrieved 26 November 2011.

[Index_nominum_2000:_international_drug_directory-3] 3.0 ^3.1 Index nominum 2000: international drug directory. Taylor & Francis US. 2000. p. 513. ISBN 978-3-88763-075-1. Retrieved 26 November 2011.

[1]

[2]

[3]

Heptabarbital

Overview

See also

References

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Clinical data

Synonyms	G-475
Pregnancy category	?
Routes of administration	Oral^[1]
ATC code	N05CA11 (WHO)
Legal status
Legal status	?
Pharmacokinetic data
Bioavailability	83%^[1]
Metabolism	Hepatic
Elimination half-life	6.1-11.2 hours^[1]
Excretion	Renal^[1]
Identifiers
IUPAC name 5-cyclohept-1-en-1-yl-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione
CAS Number	509-86-4
PubChem CID	10518
DrugBank	DB01354^Y
ChemSpider	10081^Y
UNII	V10R70ML23
KEGG	C17725^Y
ChEMBL	ChEMBL468837^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₃H₁₈N₂O₃
Molar mass	250.294 g/mol
3D model (JSmol)	Interactive image
SMILES O=C1NC(=O)NC(=O)C1(/C2=C/CCCCC2)CC
InChI InChI=1S/C13H18N2O3/c1-2-13(9-7-5-3-4-6-8-9)10(16)14-12(18)15-11(13)17/h7H,2-6,8H2,1H3,(H2,14,15,16,17,18)^Y Key:PAZQYDJGLKSCSI-UHFFFAOYSA-N^Y
(verify)