Hepatocellular adenoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Hepatocellular adenoma was first discovered by Hugh A. Edmondson in 1958 following 50,000 autopsies.^[1]

In 1958, the hepatocellular adenoma was first described by Edmondson as an encapsulated liver tumor that does not contain bile ducts, when he identified two such lesions in 50,000 autopsies.^[2]
In 1973, Baum reported the important relationship between oral contraceptive use and development of hepatocellular adenomas in seven patients.^[3]^[4]
In 1970s several subsequent case series supported the hypothesis of an association between the oral contraceptive pill and hepatocellular adenomas.^[5]
In 1976, Edmondson published a case control study giving further evidence of this association. ^[6]

↑ Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.CS1 maint: PMC format (link)
↑ Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.CS1 maint: PMC format (link)
↑ G. Klatskin (1977). "Hepatic tumors: possible relationship to use of oral contraceptives". Gastroenterology. 73 (2): 386–394. PMID 194813. Unknown parameter |month= ignored (help)
↑ J. K. Baum, J. J. Bookstein, F. Holtz & E. W. Klein (1973). "Possible association between benign hepatomas and oral contraceptives". Lancet (London, England). 2 (7835): 926–929. PMID 4126557. Unknown parameter |month= ignored (help)
↑ E. Horvath, K. Kovacs & R. C. Ross (1974). "Letter: Benign hepatoma in a young woman on contraceptive steroids". Lancet (London, England). 1 (7853): 357–358. PMID 4131203. Unknown parameter |month= ignored (help)
↑ H. A. Edmondson, B. Henderson & B. Benton (1976). "Liver-cell adenomas associated with use of oral contraceptives". The New England journal of medicine. 294 (9): 470–472. doi:10.1056/NEJM197602262940904. PMID 173996. Unknown parameter |month= ignored (help)