Hemophilia classification: Difference between revisions
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Haemophilia may be classified into three subtypes based on lack of functional clotting factors:[[Haemophilia A]] , [[Haemophilia B]], [[Haemophilia C]]. | Haemophilia may be classified into three subtypes based on lack of functional clotting factors:[[Haemophilia A]] , [[Haemophilia B]], [[Haemophilia C]]. | ||
==Classification== | ==Classification== | ||
Hemophilia may be classified as severe, moderate or mild. This is based on the levels of Factor VIII or Factor IX | Hemophilia may be classified as severe, moderate or mild. This is based on the levels of Factor VIII or Factor IX | ||
Rarely, hemophilia can be acquired. "Acquired” means you aren't born with the disorder, but you develop it during your lifetime. This can happen if your body forms antibodies (proteins) that attack the clotting factors in your bloodstream. The antibodies can prevent the clotting factors from working. | Rarely, hemophilia can be acquired. "Acquired” means you aren't born with the disorder, but you develop it during your lifetime. This can happen if your body forms antibodies (proteins) that attack the clotting factors in your bloodstream. The antibodies can prevent the clotting factors from working.<ref>{{Cite web | title = Hemophilia classification| url =http://www.cdc.gov/ncbddd/hemophilia/diagnosis.html }}</ref> | ||
*[[Haemophilia A]] is a recessive X-linked genetic disorder involving a lack of functional clotting Factor VIII and represents 80% of haemophilia cases. | *[[Haemophilia A]] is a [[recessive]] X-linked genetic disorder involving a lack of functional clotting Factor VIII and represents 80% of haemophilia cases. | ||
*[[Haemophilia B]] is a recessive X-linked genetic disorder involving a lack of functional clotting Factor IX. It comprises approximately 20% of haemophilia cases. | *[[Haemophilia B]] is a recessive X-linked genetic disorder involving a lack of functional clotting Factor IX. It comprises approximately 20% of haemophilia cases. | ||
*[[Haemophilia C]] is an autosomal genetic disorder (i.e. not X-linked) involving a lack of functional clotting Factor XI. Haemophilia C is not completely recessive, as heterozygous individuals also show increased bleeding. | *[[Haemophilia C]] is an [[autosomal]] genetic disorder (i.e. not X-linked) involving a lack of functional clotting Factor XI. Haemophilia C is not completely recessive, as heterozygous individuals also show increased bleeding. | ||
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| style="padding: 5px 5px; background: #F5F5F5;" colspan=2| <small>Adapted from CDC Hemophilia Diagnosis> {{cite web| url=http://www.cdc.gov/ncbddd/hemophilia/diagnosis.html| title=CDC Hemophilia Diagnosis }}</small> | | style="padding: 5px 5px; background: #F5F5F5;" colspan=2| <small>Adapted from CDC Hemophilia Diagnosis> {{cite web| url=http://www.cdc.gov/ncbddd/hemophilia/diagnosis.html| title=CDC Hemophilia Diagnosis }}</small> | ||
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==References== | ==References== | ||
Revision as of 23:18, 27 August 2015
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Hemophilia Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Hemophilia classification On the Web |
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American Roentgen Ray Society Images of Hemophilia classification |
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Risk calculators and risk factors for Hemophilia classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Haemophilia may be classified into three subtypes based on lack of functional clotting factors:Haemophilia A , Haemophilia B, Haemophilia C.
Classification
Hemophilia may be classified as severe, moderate or mild. This is based on the levels of Factor VIII or Factor IX Rarely, hemophilia can be acquired. "Acquired” means you aren't born with the disorder, but you develop it during your lifetime. This can happen if your body forms antibodies (proteins) that attack the clotting factors in your bloodstream. The antibodies can prevent the clotting factors from working.[1]
- Haemophilia A is a recessive X-linked genetic disorder involving a lack of functional clotting Factor VIII and represents 80% of haemophilia cases.
- Haemophilia B is a recessive X-linked genetic disorder involving a lack of functional clotting Factor IX. It comprises approximately 20% of haemophilia cases.
- Haemophilia C is an autosomal genetic disorder (i.e. not X-linked) involving a lack of functional clotting Factor XI. Haemophilia C is not completely recessive, as heterozygous individuals also show increased bleeding.
| Severity | Levels of Factor VIII (8)
or IX (9) in the blood |
|---|---|
| Normal (person who does not have hemophilia) | 50% to 100% |
| Mild hemophilia | Greater than 5% but less than 50% |
| Moderate hemophilia | 1% to 5% |
| Severe hemophilia | Less than 1% |
| Adapted from CDC Hemophilia Diagnosis> "CDC Hemophilia Diagnosis". | |