Hemochromatosis MRI

Revision as of 18:26, 1 January 2019 by Shyam Patel (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Hemochromatosis Microchapters


Patient Information


Historical Perspective




Differentiating Hemochromatosis from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings


X Ray



Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hemochromatosis MRI On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Hemochromatosis MRI

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hemochromatosis MRI

CDC on Hemochromatosis MRI

Hemochromatosis MRI in the news

Blogs on Hemochromatosis MRI

Directions to Hospitals Treating Hemochromatosis

Risk calculators and risk factors for Hemochromatosis MRI

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sunny Kumar MD [3]


MRI is not only the most sensitive imaging modality for the diagnosis of haemochromatosis but is also able to estimate iron concentration within the liver, thus forestalling the need for repeated biopsies.


MRI is not only the most sensitive imaging modality for the diagnosis of haemochromatosis but is also able to estimate iron concentration within the liver and cardiac muscle, thus forestalling the need for repeated biopsies.[1]

MR liver (or heart) iron quantification is a non-invasive means of measuring liver iron concentration, a key indicator in the management of patients with haemochromatosis (primary or secondary)

Following are the methods of measurements:

  1. Signal intensity ratio (SIR)-The ratio between the signal intensity of the liver and the signal intensity of paraspinal muscle that does not accumulate iron can be used to determine liver iron concentration.
  2. T2 relaxometry vs. SIR methods-Estimating liver iron content is easier to perform with SIR compared with T2 relaxometry. SIR methods are less accurate at an iron concentration of >350 micromol Fe/g.
  3. T2 relaxometry-ron within liver has paramagnetic properties and results in a decrease in T2 relaxation times. The accelerated relaxation is proportional to iron content. Decay models are attributed to the average signal intensity at different echo times.
  • MRI carries no risk for radiation, unlike CT scan.
  • MRI is significantly more expensive than CT scan.


  1. St Pierre TG, Clark PR, Chua-anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK; et al. (2005). "Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance". Blood. 105 (2): 855–61. doi:10.1182/blood-2004-01-0177. PMID 15256427.

Template:WS Template:WH