Helicobacter pylori infection diagnostic tests: Difference between revisions
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*Culture | *Culture | ||
*Polymerase chain reaction | *Polymerase chain reaction | ||
===Histology=== | |||
*Histology for H.pylori detection depends on: | |||
:*Site, number, and size of gastric biopsies | |||
:*Method of staining | |||
:*Level of experience of the examining pathologist | |||
*Advantage of histology over other diagnostic studies is its ability to detect the pathological changes associated with H.pylori infection such as inflammation, atrophy, intestinal metaplasia and malignancy. | |||
*Multiple biopsies are required for accurate diagnosis as the prevalence and density of H.pylori varies throughout the stomach. Therefore a minimum of three biopsies are taken from different sites. They are: | |||
:*Angularis | |||
:*Greater curvature of the corpus | |||
:*Greater curvature of the antrum | |||
*The sensitivity of histology is greatly effected by the use of medications such as bismuth, antibiotics, and PPI. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} |
Revision as of 18:49, 16 January 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]
Overview
Endoscopic Diagnostic Tests
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Endoscopic diagnostic tests are biopsy-based diagnostic methods for H.pylori infection. These include:
- Histology
- Rapid urease testing
- Culture
- Polymerase chain reaction
Histology
- Histology for H.pylori detection depends on:
- Site, number, and size of gastric biopsies
- Method of staining
- Level of experience of the examining pathologist
- Advantage of histology over other diagnostic studies is its ability to detect the pathological changes associated with H.pylori infection such as inflammation, atrophy, intestinal metaplasia and malignancy.
- Multiple biopsies are required for accurate diagnosis as the prevalence and density of H.pylori varies throughout the stomach. Therefore a minimum of three biopsies are taken from different sites. They are:
- Angularis
- Greater curvature of the corpus
- Greater curvature of the antrum
- The sensitivity of histology is greatly effected by the use of medications such as bismuth, antibiotics, and PPI.