Hairy cell leukemia differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.

Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.^[1]


Differential Diagnosis	Surface Immunoglobulin	CD5	CD22/FMC7	CD23	CD79b	CD103

Hairy cell leukaemia	Strongly positive	Negative	Positive	Negative	Positive/Negative	Positive
Chronic lymphocytic leukaemia	Weakly positive	Positive	Negative	Positive	Negative	Positive/Negative
Prolymphocytic leukaemia	Strongly positive	Negative	Positive	Negative	Positive	Negative
Mantle cell lymphoma	Positive	Positive	Strongly positive	Negative	Strongly positive	Negative
Follicular lymphoma	Strongly positive	Negative	Positive	Negative	Strongly positive	Negative

Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:^[2]^[3]

↑ Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
↑ Duggan DJ, Bittner M, Chen Y, Meltzer P, Trent JM (January 1999). "Expression profiling using cDNA microarrays". Nat. Genet. 21 (1 Suppl): 10–4. doi:10.1038/4434. PMID 9915494.
↑ Vanhentenrijk V, De Wolf-Peeters C, Wlodarska I (July 2004). "Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature". Blood. 104 (1): 250–5. doi:10.1182/blood-2004-01-0181. PMID 15016649.