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==Overview==
==Overview==
* Hairy cell leukemia may be classified  into two subtypes which include hairy cell leukemia (classic) and hairy cell leukemia variant.<ref name="wiki">Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Classification Accessed on October, 17 2015</ref>
* Hairy cell leukemia may be classified  into two subtypes which include hairy cell leukemia (classic) and hairy cell leukemia variant.


==Classification==
==Classification==

Revision as of 18:21, 14 October 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

  • Hairy cell leukemia may be classified into two subtypes which include hairy cell leukemia (classic) and hairy cell leukemia variant.

Classification

  • Hairy cell leukemia may be classified into two subtypes which include:[1]
  • Hairy cell leukemia (classic)
  • Hairy cell leukemia variant
  • Hairy cell leukemia variant is still considered a provisional entity at this time, as the WHO is unable to recognize it as distinct diseases due to insufficient evidence.[2]
  • The chart below illustrates characteristic findings associated with each subtype:[3][4]


 
 
 
 
 
 
 
Hairy cell leukemia classification
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Hairy cell leukemia
 
Hairy cell leukemia variant
 
 
 
 
 
  • Occurs in approximately 95% of the cases
  • The male to female ratio is approximately 4 to 1
  • The median age at diagnosis is 55 years
  • Less than 10% lymphocytosis is observed
  • Decreased level of monocyte on peripheral blood smear
  • Decreased hemoglobin level in approximately 85% of the patients
  • Thrombocytopenia is present in approximately 80% of the patients
  • CD103 +ve, CD11c +ve, and CD25 +ve on immunophenotype
  • DBA 44 +ve, Cyclin D1 +ve, and Annexin A1 +ve on immunohistochemistry
  • Presence of BRAF V600E mutation on cytogenetic tests
 
  • Occurs in approximately 5% of the cases
  • The male to female ratio is approximately 2 to 1
  • The median age at diagnosis is greater than 70 years
  • Greater than 90% lymphocytosis is observed
  • Normal level of monocyte on peripheral blood smear
  • Normal hemoglobin level in most of the patients
  • Normal platelets count in most of the patients
  • CD103 +ve, CD11c +ve, and CD25 -ve on immunophenotype
  • DBA 44 +ve, Cyclin D1 +ve, and Annexin A1 -ve on immunohistochemistry
  • Presence of BRAF wild type mutation on cytogenetic tests



References

  1. Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Classification Accessed on October, 17 2015
  2. Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES (2011). "The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications". Blood. 117 (19): 5019–32. doi:10.1182/blood-2011-01-293050. PMC 3109529. PMID 21300984.
  3. Matutes E (2006). "Immunophenotyping and differential diagnosis of hairy cell leukemia". Hematol Oncol Clin North Am. 20 (5): 1051–63. doi:10.1016/j.hoc.2006.06.012. PMID 16990106.
  4. Hairy-Cell Leukemia. Onkopedia (2015) https://www.onkopedia-guidelines.info/en/onkopedia/guidelines/hairy-cell-leukemia/@@view/html/index.html#5 Accessed on October, 16 2015


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