HOXD10

Homeobox D10
Identifiers
Symbols	HOXD10 ; HOX4; HOX4E; HOX4D; Hox-4.4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1619
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox D10, also known as HOXD10, is a human gene.

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.

See also

• Homeobox

Further reading

• Tabin CJ (1993). "Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs". Development. 116 (2): 289–96. PMID 1363084.
• Goodman FR (2003). "Limb malformations and the human HOX genes". Am. J. Med. Genet. 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469.
• Redline RW, Williams AJ, Patterson P, Collins T (1992). "Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts". Genomics. 13 (2): 425–30. PMID 1351871.CS1 maint: Multiple names: authors list (link)
• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• Zappavigna V, Renucci A, Izpisúa-Belmonte JC; et al. (1992). "HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities". EMBO J. 10 (13): 4177–87. PMID 1756725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Peverali FA, D'Esposito M, Acampora D; et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–9. PMID 1981366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boncinelli E, Acampora D, Pannese M; et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guazzi S, Lonigro R, Pintonello L; et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. PMID 7913891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Redline RW, Hudock P, MacFee M, Patterson P (1994). "Expression of AbdB-type homeobox genes in human tumors". Lab. Invest. 71 (5): 663–70. PMID 7967520.CS1 maint: Multiple names: authors list (link)
• Wulfsberg EA, Mirkinson LJ, Meister SJ (1993). "Autosomal dominant tetramelic postaxial oligodactyly". Am. J. Med. Genet. 46 (5): 579–83. doi:10.1002/ajmg.1320460524. PMID 8100684.CS1 maint: Multiple names: authors list (link)
• Osborne J, Hu C, Hawley C; et al. (1998). "Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma". J. Soc. Gynecol. Investig. 5 (5): 277–80. PMID 9773404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Del Campo M, Jones MC, Veraksa AN; et al. (1999). "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". Am. J. Hum. Genet. 65 (1): 104–10. PMID 10364522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shanmugam K, Green NC, Rambaldi I; et al. (1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Mol. Cell. Biol. 19 (11): 7577–88. PMID 10523646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1". Cytogenet. Cell Genet. 90 (1–2): 151–3. PMID 11060466.CS1 maint: Multiple names: authors list (link)
• Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.CS1 maint: Multiple names: authors list (link)
• Goodman FR, Majewski F, Collins AL, Scambler PJ (2002). "A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly". Am. J. Hum. Genet. 70 (2): 547–55. PMID 11778160.CS1 maint: Multiple names: authors list (link)
• Kosaki K, Kosaki R, Suzuki T; et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HOXD10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.