HOXD10: Difference between revisions

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Revision as of 14:01, 31 August 2017

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.^[1]

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.^[1]^{[citation needed]}

Regulation

The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.^[2]^[3]^[4]

References

↑ ^1.0 ^1.1 "Entrez Gene: HOXD10 homeobox D10".
↑ Lund AH (Feb 2010). "miR-10 in development and cancer". Cell Death and Differentiation. 17 (2): 209–14. doi:10.1038/cdd.2009.58. PMID 19461655.
↑ Ma L, Teruya-Feldstein J, Weinberg RA (Oct 2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature. 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713.
↑ Han L, Witmer PD, Casey E, Valle D, Sukumar S (Aug 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. PMID 17660710.

Ma L, Teruya-Feldstein J, Weinberg RA (Oct 2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature. 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713.
Tabin CJ (Oct 1992). "Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs". Development. 116 (2): 289–96. PMID 1363084.
Goodman FR (Oct 2002). "Limb malformations and the human HOX genes". American Journal of Medical Genetics. 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469.
Redline RW, Williams AJ, Patterson P, Collins T (Jun 1992). "Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts". Genomics. 13 (2): 425–30. doi:10.1016/0888-7543(92)90263-R. PMID 1351871.
Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
Zappavigna V, Renucci A, Izpisúa-Belmonte JC, Urier G, Peschle C, Duboule D (Dec 1991). "HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities". The EMBO Journal. 10 (13): 4177–87. PMC 453170. PMID 1756725.
McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (Oct 1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity. 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal. 13 (14): 3339–47. PMC 395231. PMID 7913891.
Redline RW, Hudock P, MacFee M, Patterson P (Nov 1994). "Expression of AbdB-type homeobox genes in human tumors". Laboratory Investigation; A Journal of Technical Methods and Pathology. 71 (5): 663–70. PMID 7967520.
Wulfsberg EA, Mirkinson LJ, Meister SJ (Jun 1993). "Autosomal dominant tetramelic postaxial oligodactyly". American Journal of Medical Genetics. 46 (5): 579–83. doi:10.1002/ajmg.1320460524. PMID 8100684.
Osborne J, Hu C, Hawley C, Underwood LJ, O'Brien TJ, Baker VV (1998). "Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma". Journal of the Society for Gynecologic Investigation. 5 (5): 277–80. doi:10.1016/S1071-5576(98)00020-3. PMID 9773404.
Del Campo M, Jones MC, Veraksa AN, Curry CJ, Jones KL, Mascarello JT, Ali-Kahn-Catts Z, Drumheller T, McGinnis W (Jul 1999). "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". American Journal of Human Genetics. 65 (1): 104–10. doi:10.1086/302467. PMC 1378080. PMID 10364522.
Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. PMC 84774. PMID 10523646.
Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1". Cytogenetics and Cell Genetics. 90 (1–2): 151–3. doi:10.1159/000015651. PMID 11060466.
Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
Goodman FR, Majewski F, Collins AL, Scambler PJ (Feb 2002). "A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly". American Journal of Human Genetics. 70 (2): 547–55. doi:10.1086/338921. PMC 384929. PMID 11778160.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.

External links

HOXD10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: HOXD10 homeobox D10".

[pmid19461655-2] Lund AH (Feb 2010). "miR-10 in development and cancer". Cell Death and Differentiation. 17 (2): 209–14. doi:10.1038/cdd.2009.58. PMID 19461655.

[pmid17898713-3] Ma L, Teruya-Feldstein J, Weinberg RA (Oct 2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature. 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713.

[pmid17660710-4] Han L, Witmer PD, Casey E, Valle D, Sukumar S (Aug 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. PMID 17660710.

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[2]

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Homeobox D10''', also known as '''HOXD10''', is a [[protein]] which in humans is encoded by the ''HOXD10'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXD10 homeobox D10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3236| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Homeobox D10
- | HGNCid = 5133
- | Symbol = HOXD10
- | AltSymbols =; HOX4; HOX4E; HOX4D; Hox-4.4
- | OMIM = 142984
- | ECnumber =
- | Homologene = 1619
- | MGIid = 96202
- | GeneAtlas_image1 = PBB_GE_HOXD10_207373_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3236
-    | Hs_Ensembl = ENSG00000128710
-    | Hs_RefseqProtein = NP_002139
-    | Hs_RefseqmRNA = NM_002148
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 176689746
-    | Hs_GenLoc_end = 176692672
-    | Hs_Uniprot = P28358
-    | Mm_EntrezGene = 15430
-    | Mm_Ensembl = ENSMUSG00000050368
-    | Mm_RefseqmRNA = NM_013554
-    | Mm_RefseqProtein = NP_038582
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 74492809
-    | Mm_GenLoc_end = 74495942
-    | Mm_Uniprot = P28359
-  }}
-}}
-'''Homeobox D10''', also known as '''HOXD10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXD10 homeobox D10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3236| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene is a member of the Abd-B [[homeobox]] family and encodes a protein with a homeobox [[DNA-binding domain]]. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific [[transcription factor]] that is expressed in the developing limb buds and is involved in differentiation and limb development.
-{{PBB_Summary
-| section_title =
-| summary_text = This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as &quot;rocker-bottom foot&quot; deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.<ref name="entrez">{{cite web | title = Entrez Gene: HOXD10 homeobox D10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3236| accessdate = }}</ref>
-}}
-==See also==
+== Clinical significance ==
+Mutations in this gene have been associated with [[Wilms' tumor]] and congenital vertical talus (also known as "[[rocker-bottom foot]]" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in [[Charcot-Marie-Tooth disease]].<ref name="entrez"/>{{citation needed|date=February 2012}}
+== Regulation ==
+The ''HOXD10'' gene is [[Gene expression|repressed]] by the [[microRNAs]] [[Mir-10 microRNA precursor family|miR-10a]] and [[Mir-10 microRNA precursor family|miR-10b]].<ref name="pmid19461655">{{cite journal | vauthors = Lund AH | title = miR-10 in development and cancer | journal = Cell Death and Differentiation | volume = 17 | issue = 2 | pages = 209–14 | date = Feb 2010 | pmid = 19461655 | doi = 10.1038/cdd.2009.58 | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19461655 }} </ref><ref name="pmid17898713">{{cite journal | vauthors = Ma L, Teruya-Feldstein J, Weinberg RA | title = Tumour invasion and metastasis initiated by microRNA-10b in breast cancer | journal = Nature | volume = 449 | issue = 7163 | pages = 682–8 | date = Oct 2007 | pmid = 17898713 | doi = 10.1038/nature06174 | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17898713 }} </ref><ref name="pmid17660710">{{cite journal | vauthors = Han L, Witmer PD, Casey E, Valle D, Sukumar S | title = DNA methylation regulates MicroRNA expression | journal = Cancer Biology & Therapy | volume = 6 | issue = 8 | pages = 1284–8 | date = Aug 2007 | pmid = 17660710 | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17660710 }} </ref>
+== See also ==
 * [[Homeobox]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Ma L, Teruya-Feldstein J, Weinberg RA | title = Tumour invasion and metastasis initiated by microRNA-10b in breast cancer | journal = Nature | volume = 449 | issue = 7163 | pages = 682–8 | date = Oct 2007 | pmid = 17898713 | doi = 10.1038/nature06174 }}
-| citations =
+* {{cite journal | vauthors = Tabin CJ | title = Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs | journal = Development | volume = 116 | issue = 2 | pages = 289–96 | date = Oct 1992 | pmid = 1363084 | doi =  }}
-*{{cite journal  | author=Tabin CJ |title=Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs. |journal=Development |volume=116 |issue= 2 |pages= 289-96 |year= 1993 |pmid= 1363084 |doi=  }}
+* {{cite journal | vauthors = Goodman FR | title = Limb malformations and the human HOX genes | journal = American Journal of Medical Genetics | volume = 112 | issue = 3 | pages = 256–65 | date = Oct 2002 | pmid = 12357469 | doi = 10.1002/ajmg.10776 }}
-*{{cite journal  | author=Goodman FR |title=Limb malformations and the human HOX genes. |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 256-65 |year= 2003 |pmid= 12357469 |doi= 10.1002/ajmg.10776 }}
+* {{cite journal | vauthors = Redline RW, Williams AJ, Patterson P, Collins T | title = Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts | journal = Genomics | volume = 13 | issue = 2 | pages = 425–30 | date = Jun 1992 | pmid = 1351871 | doi = 10.1016/0888-7543(92)90263-R }}
-*{{cite journal  | author=Redline RW, Williams AJ, Patterson P, Collins T |title=Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. |journal=Genomics |volume=13 |issue= 2 |pages= 425-30 |year= 1992 |pmid= 1351871 |doi=  }}
+* {{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | doi = 10.1016/0092-8674(92)90588-4 }}
-*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
+* {{cite journal | vauthors = Zappavigna V, Renucci A, Izpisúa-Belmonte JC, Urier G, Peschle C, Duboule D | title = HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities | journal = The EMBO Journal | volume = 10 | issue = 13 | pages = 4177–87 | date = Dec 1991 | pmid = 1756725 | pmc = 453170 | doi =  }}
-*{{cite journal  | author=Zappavigna V, Renucci A, Izpisúa-Belmonte JC, ''et al.'' |title=HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. |journal=EMBO J. |volume=10 |issue= 13 |pages= 4177-87 |year= 1992 |pmid= 1756725 |doi=  }}
+* {{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | doi = 10.1016/0888-7543(90)90186-X }}
-*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
+* {{cite journal | vauthors = Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A | title = Expression of HOX homeogenes in human neuroblastoma cell culture lines | journal = Differentiation; Research in Biological Diversity | volume = 45 | issue = 1 | pages = 61–9 | date = Oct 1990 | pmid = 1981366 | doi = 10.1111/j.1432-0436.1990.tb00458.x }}
-*{{cite journal  | author=Peverali FA, D'Esposito M, Acampora D, ''et al.'' |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61-9 |year= 1991 |pmid= 1981366 |doi=  }}
+* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
-*{{cite journal  | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi=  }}
+* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada | volume = 31 | issue = 2 | pages = 745–56 | year = 1990 | pmid = 2576652 | doi = 10.1139/g89-133 }}
-*{{cite journal  | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi=  }}
+* {{cite journal | vauthors = Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F | title = The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins | journal = The EMBO Journal | volume = 13 | issue = 14 | pages = 3339–47 | date = Jul 1994 | pmid = 7913891 | pmc = 395231 | doi =  }}
-*{{cite journal  | author=Guazzi S, Lonigro R, Pintonello L, ''et al.'' |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339-47 |year= 1994 |pmid= 7913891 |doi=  }}
+* {{cite journal | vauthors = Redline RW, Hudock P, MacFee M, Patterson P | title = Expression of AbdB-type homeobox genes in human tumors | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 71 | issue = 5 | pages = 663–70 | date = Nov 1994 | pmid = 7967520 | doi =  }}
-*{{cite journal  | author=Redline RW, Hudock P, MacFee M, Patterson P |title=Expression of AbdB-type homeobox genes in human tumors. |journal=Lab. Invest. |volume=71 |issue= 5 |pages= 663-70 |year= 1994 |pmid= 7967520 |doi=  }}
+* {{cite journal | vauthors = Wulfsberg EA, Mirkinson LJ, Meister SJ | title = Autosomal dominant tetramelic postaxial oligodactyly | journal = American Journal of Medical Genetics | volume = 46 | issue = 5 | pages = 579–83 | date = Jun 1993 | pmid = 8100684 | doi = 10.1002/ajmg.1320460524 }}
-*{{cite journal  | author=Wulfsberg EA, Mirkinson LJ, Meister SJ |title=Autosomal dominant tetramelic postaxial oligodactyly. |journal=Am. J. Med. Genet. |volume=46 |issue= 5 |pages= 579-83 |year= 1993 |pmid= 8100684 |doi= 10.1002/ajmg.1320460524 }}
+* {{cite journal | vauthors = Osborne J, Hu C, Hawley C, Underwood LJ, O'Brien TJ, Baker VV | title = Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma | journal = Journal of the Society for Gynecologic Investigation | volume = 5 | issue = 5 | pages = 277–80 | year = 1998 | pmid = 9773404 | doi = 10.1016/S1071-5576(98)00020-3 }}
-*{{cite journal  | author=Osborne J, Hu C, Hawley C, ''et al.'' |title=Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma. |journal=J. Soc. Gynecol. Investig. |volume=5 |issue= 5 |pages= 277-80 |year= 1998 |pmid= 9773404 |doi=  }}
+* {{cite journal | vauthors = Del Campo M, Jones MC, Veraksa AN, Curry CJ, Jones KL, Mascarello JT, Ali-Kahn-Catts Z, Drumheller T, McGinnis W | title = Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster | journal = American Journal of Human Genetics | volume = 65 | issue = 1 | pages = 104–10 | date = Jul 1999 | pmid = 10364522 | pmc = 1378080 | doi = 10.1086/302467 }}
-*{{cite journal  | author=Del Campo M, Jones MC, Veraksa AN, ''et al.'' |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104-10 |year= 1999 |pmid= 10364522 |doi=  }}
+* {{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi =  }}
-*{{cite journal  | author=Shanmugam K, Green NC, Rambaldi I, ''et al.'' |title=PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7577-88 |year= 1999 |pmid= 10523646 |doi=  }}
+* {{cite journal | vauthors = Limongi MZ, Pelliccia F, Gaddini L, Rocchi A | title = Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1 | journal = Cytogenetics and Cell Genetics | volume = 90 | issue = 1-2 | pages = 151–3 | year = 2000 | pmid = 11060466 | doi = 10.1159/000015651 }}
-*{{cite journal  | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151-3 |year= 2000 |pmid= 11060466 |doi=  }}
+* {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}
-*{{cite journal  | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509-22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001 }}
+* {{cite journal | vauthors = Goodman FR, Majewski F, Collins AL, Scambler PJ | title = A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly | journal = American Journal of Human Genetics | volume = 70 | issue = 2 | pages = 547–55 | date = Feb 2002 | pmid = 11778160 | pmc = 384929 | doi = 10.1086/338921 }}
-*{{cite journal  | author=Goodman FR, Majewski F, Collins AL, Scambler PJ |title=A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. |journal=Am. J. Hum. Genet. |volume=70 |issue= 2 |pages= 547-55 |year= 2002 |pmid= 11778160 |doi=  }}
+* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
-*{{cite journal  | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
-}}
 {{refend}}
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 {{NLM content}}
-{{protein-stub}}
-{{Transcription factors}}
+{{Transcription factors|g3}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-2-stub}}

HOXD10: Difference between revisions

Revision as of 14:01, 31 August 2017

Contents

Function

Clinical significance

Regulation

See also

References

Further reading

External links

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