HOXB1

Homeobox B1
File:PBB Protein HOXB1 image.jpg PDB rendering based on 1b72.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b72​
Identifiers
Symbols	HOXB1 ; HOX2; HOX2I; Hox-2.9; MGC116843; MGC116844; MGC116845
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1615
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox B1, also known as HOXB1, is a human gene.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.

See also

• Homeobox

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boncinelli E, Acampora D, Pannese M; et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guazzi S, Lonigro R, Pintonello L; et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. PMID 7913891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miano JM, Firulli AB, Olson EN; et al. (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–5. PMID 8570656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Apiou F, Flagiello D, Cillo C; et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. PMID 8646877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berthelsen J, Zappavigna V, Ferretti E; et al. (1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMID 9482740.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Piper DE, Batchelor AH, Chang CP; et al. (1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. PMID 10052460.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jungbluth S, Bell E, Lumsden A (1999). "Specification of distinct motor neuron identities by the singular activities of individual Hox genes". Development. 126 (12): 2751–8. PMID 10331985.CS1 maint: Multiple names: authors list (link)
• Jacobs Y, Schnabel CA, Cleary ML (1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Mol. Cell. Biol. 19 (7): 5134–42. PMID 10373562.CS1 maint: Multiple names: authors list (link)
• Faiella A, Zortea M, Barbaria E; et al. (2000). "A genetic polymorphism in the human HOXB1 homeobox gene implying a 9bp tandem repeat in the amino-terminal coding region. Mutations in brief no. 200. Online". Hum. Mutat. 12 (5): 363. PMID 10671062.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mikkola I, Bruun JA, Holm T, Johansen T (2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins". J. Biol. Chem. 276 (6): 4109–18. doi:10.1074/jbc.M008882200. PMID 11069920.CS1 maint: Multiple names: authors list (link)
• Ingram JL, Stodgell CJ, Hyman SL; et al. (2001). "Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders". Teratology. 62 (6): 393–405. doi:10.1002/1096-9926(200012)62:6<393::AID-TERA6>3.0.CO;2-V. PMID 11091361.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Di Rocco G, Gavalas A, Popperl H; et al. (2001). "The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function". J. Biol. Chem. 276 (23): 20506–15. doi:10.1074/jbc.M011175200. PMID 11278854.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Tabor HK, Nguyen L; et al. (2002). "Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families". Am. J. Med. Genet. 114 (1): 24–30. PMID 11840501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kosaki K, Kosaki R, Suzuki T; et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fognani C, Kilstrup-Nielsen C, Berthelsen J; et al. (2002). "Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors". Nucleic Acids Res. 30 (9): 2043–51. PMID 11972344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Subramaniam N, Campión J, Rafter I, Okret S (2003). "Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1". Biochem. J. 370 (Pt 3): 1087–95. doi:10.1042/BJ20020471. PMID 12487626.CS1 maint: Multiple names: authors list (link)

External links

• HOXB1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.