HOXB1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>KolbertBot
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Use dmy dates|date=April 2013}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Homeobox protein Hox-B1''' is a [[protein]] that in humans is encoded by the ''HOXB1'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460  | date = Aug 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3  | date = Dec 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXB1 homeobox B1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3211| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_HOXB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b72.
| PDB = {{PDB2|1b72}}
| Name = Homeobox B1
| HGNCid = 5111
| Symbol = HOXB1
| AltSymbols =; HOX2; HOX2I; Hox-2.9; MGC116843; MGC116844; MGC116845
| OMIM = 142968
| ECnumber = 
| Homologene = 1615
| MGIid = 96182
| GeneAtlas_image1 = PBB_GE_HOXB1_208224_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007389 |text = pattern specification process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3211
    | Hs_Ensembl = ENSG00000120094
    | Hs_RefseqProtein = NP_002135
    | Hs_RefseqmRNA = NM_002144
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 43961813
    | Hs_GenLoc_end = 43963271
    | Hs_Uniprot = P14653
    | Mm_EntrezGene = 15407
    | Mm_Ensembl = ENSMUSG00000018973
    | Mm_RefseqmRNA = NM_008266
    | Mm_RefseqProtein = NP_032292
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96181848
    | Mm_GenLoc_end = 96183766
    | Mm_Uniprot = P17919
  }}
}}
'''Homeobox B1''', also known as '''HOXB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXB1 homeobox B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3211| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.<ref name="entrez">{{cite web | title = Entrez Gene: HOXB1 homeobox B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3211| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
HOXB1 has been shown to [[Protein-protein interaction|interact]] with [[PBX1]].<ref name=pmid9482740>{{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = EMBO J. | volume = 17 | issue = 5 | pages = 1434–45  | date = Mar 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}</ref><ref name=pmid10052460>{{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–97  | date = Feb 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5 }}</ref>
 
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Res. | volume = 17 | issue = 24 | pages = 10385–402 | year = 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
| citations =
* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–56 | year = 1989 | pmid = 2576652 | doi = 10.1139/g89-133 }}
*{{cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi= }}
* {{cite journal | vauthors = Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F | title = The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins | journal = EMBO J. | volume = 13 | issue = 14 | pages = 3339–47 | year = 1994 | pmid = 7913891 | pmc = 395231 | doi =  }}
*{{cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi= }}
* {{cite journal | vauthors = Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM | title = Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 2 | pages = 900–5 | year = 1996 | pmid = 8570656 | pmc = 40155 | doi = 10.1073/pnas.93.2.900 }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi=  }}
* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenet. Cell Genet. | volume = 73 | issue = 1–2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi= }}
* {{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = EMBO J. | volume = 17 | issue = 5 | pages = 1434–45 | year = 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}
*{{cite journal | author=Guazzi S, Lonigro R, Pintonello L, ''et al.'' |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339-47 |year= 1994 |pmid= 7913891 |doi= }}
* {{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–97 | year = 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5 }}
*{{cite journal | author=Miano JM, Firulli AB, Olson EN, ''et al.'' |title=Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 900-5 |year= 1996 |pmid= 8570656 |doi= }}
* {{cite journal | vauthors = Jungbluth S, Bell E, Lumsden A | title = Specification of distinct motor neuron identities by the singular activities of individual Hox genes | journal = Development | volume = 126 | issue = 12 | pages = 2751–8 | year = 1999 | pmid = 10331985 | doi = }}
*{{cite journal | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi= }}
* {{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Mol. Cell. Biol. | volume = 19 | issue = 7 | pages = 5134–42 | year = 1999 | pmid = 10373562 | pmc = 84356 | doi =  }}
*{{cite journal | author=Berthelsen J, Zappavigna V, Ferretti E, ''et al.'' |title=The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1434-45 |year= 1998 |pmid= 9482740 |doi= 10.1093/emboj/17.5.1434 }}
* {{cite journal | vauthors = Faiella A, Zortea M, Barbaria E, Albani F, Capra V, Cama A, Boncinelli E | title = A genetic polymorphism in the human HOXB1 homeobox gene implying a 9bp tandem repeat in the amino-terminal coding region. Mutations in brief no. 200. Online | journal = Hum. Mutat. | volume = 12 | issue = 5 | pages = 363 | year = 1998 | pmid = 10671062 | doi =  }}
*{{cite journal | author=Piper DE, Batchelor AH, Chang CP, ''et al.'' |title=Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. |journal=Cell |volume=96 |issue= 4 |pages= 587-97 |year= 1999 |pmid= 10052460 |doi=  }}
* {{cite journal | vauthors = Mikkola I, Bruun JA, Holm T, Johansen T | title = Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins | journal = J. Biol. Chem. | volume = 276 | issue = 6 | pages = 4109–18 | year = 2001 | pmid = 11069920 | doi = 10.1074/jbc.M008882200 }}
*{{cite journal | author=Jungbluth S, Bell E, Lumsden A |title=Specification of distinct motor neuron identities by the singular activities of individual Hox genes. |journal=Development |volume=126 |issue= 12 |pages= 2751-8 |year= 1999 |pmid= 10331985 |doi=  }}
* {{cite journal | vauthors = Ingram JL, Stodgell CJ, Hyman SL, Figlewicz DA, Weitkamp LR, Rodier PM | title = Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders | journal = Teratology | volume = 62 | issue = 6 | pages = 393–405 | year = 2000 | pmid = 11091361 | doi = 10.1002/1096-9926(200012)62:6<393::AID-TERA6>3.0.CO;2-V }}
*{{cite journal | author=Jacobs Y, Schnabel CA, Cleary ML |title=Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5134-42 |year= 1999 |pmid= 10373562 |doi= }}
* {{cite journal | vauthors = Di Rocco G, Gavalas A, Popperl H, Krumlauf R, Mavilio F, Zappavigna V | title = The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function | journal = J. Biol. Chem. | volume = 276 | issue = 23 | pages = 20506–15 | year = 2001 | pmid = 11278854 | doi = 10.1074/jbc.M011175200 }}
*{{cite journal | author=Faiella A, Zortea M, Barbaria E, ''et al.'' |title=A genetic polymorphism in the human HOXB1 homeobox gene implying a 9bp tandem repeat in the amino-terminal coding region. Mutations in brief no. 200. Online. |journal=Hum. Mutat. |volume=12 |issue= 5 |pages= 363 |year= 2000 |pmid= 10671062 |doi= }}
* {{cite journal | vauthors = Li J, Tabor HK, Nguyen L, Gleason C, Lotspeich LJ, Spiker D, Risch N, Myers RM | title = Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families | journal = Am. J. Med. Genet. | volume = 114 | issue = 1 | pages = 24–30 | year = 2002 | pmid = 11840501 | doi = 10.1002/ajmg.1618 }}
*{{cite journal  | author=Mikkola I, Bruun JA, Holm T, Johansen T |title=Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4109-18 |year= 2001 |pmid= 11069920 |doi= 10.1074/jbc.M008882200 }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | year = 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=Ingram JL, Stodgell CJ, Hyman SL, ''et al.'' |title=Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders. |journal=Teratology |volume=62 |issue= 6 |pages= 393-405 |year= 2001 |pmid= 11091361 |doi= 10.1002/1096-9926(200012)62:6<393::AID-TERA6>3.0.CO;2-V }}
* {{cite journal | vauthors = Fognani C, Kilstrup-Nielsen C, Berthelsen J, Ferretti E, Zappavigna V, Blasi F | title = Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors | journal = Nucleic Acids Res. | volume = 30 | issue = 9 | pages = 2043–51 | year = 2002 | pmid = 11972344 | pmc = 113854 | doi = 10.1093/nar/30.9.2043 }}
*{{cite journal | author=Di Rocco G, Gavalas A, Popperl H, ''et al.'' |title=The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20506-15 |year= 2001 |pmid= 11278854 |doi= 10.1074/jbc.M011175200 }}
* {{cite journal | vauthors = Subramaniam N, Campión J, Rafter I, Okret S | title = Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1 | journal = Biochem. J. | volume = 370 | issue = Pt 3 | pages = 1087–95 | year = 2003 | pmid = 12487626 | pmc = 1223238 | doi = 10.1042/BJ20020471 }}
*{{cite journal | author=Li J, Tabor HK, Nguyen L, ''et al.'' |title=Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families. |journal=Am. J. Med. Genet. |volume=114 |issue= 1 |pages= 24-30 |year= 2002 |pmid= 11840501 |doi= }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal  | author=Fognani C, Kilstrup-Nielsen C, Berthelsen J, ''et al.'' |title=Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors. |journal=Nucleic Acids Res. |volume=30 |issue= 9 |pages= 2043-51 |year= 2002 |pmid= 11972344 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Subramaniam N, Campión J, Rafter I, Okret S |title=Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1. |journal=Biochem. J. |volume=370 |issue= Pt 3 |pages= 1087-95 |year= 2003 |pmid= 12487626 |doi= 10.1042/BJ20020471 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|HOXB1+protein,+human}}
* {{MeshName|HOXB1+protein,+human}}
{{PDB Gallery|geneid=3211}}
{{Transcription factors|g3}}


{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-17-stub}}

Latest revision as of 14:01, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.[1][2][3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.[3]

Interactions

HOXB1 has been shown to interact with PBX1.[4][5]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXB1 homeobox B1".
  4. ↑ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491. PMID 9482740.
  5. ↑ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=HOXB1&oldid=1529381"