HNRNPLL: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Heterogeneous nuclear ribonucleoprotein L-like''' is a [[protein]] that in humans is encoded by the HNRNPLL [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like | url = https://www.ncbi.nlm.nih.gov/gene/92906 }}</ref>


'''Heterogeneous nuclear ribonucleoprotein L-like''' is a [[protein]] that in humans is encoded by the HNRNPLL [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like
| url = https://www.ncbi.nlm.nih.gov/gene/92906
| accessdate = 2014-01-24 <!-- T03:33:26.915010-08:00 -->
}}</ref>


==Function==
HNRNPLL is a master regulator of activation-induced [[alternative splicing]] in [[T cells]]. In particular, it alters splicing of [[CD45]] (PTPRC; MIM 151460), a [[tyrosine phosphatase]] essential for T-cell development and [[T cell#Activation|activation]].<ref>{{cite journal | vauthors = Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A | title = Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL | journal = Science | volume = 321 | issue = 5889 | pages = 686–91 | date = August 2008 | pmid = 18669861 | doi = 10.1126/science.1157610 | pmc = 2791692 }}</ref>
 
HNRNPLL is a master regulator of activation-induced [[alternative splicing]] in [[T cells]]. In particular, it alters splicing of [[CD45]] (PTPRC; MIM 151460), a [[tyrosine phosphatase]] essential for T-cell development and [[T_cell#Activation|activation]] (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008].


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal  
* {{cite journal | vauthors = Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y | title = Proteomic dissection of the von Hippel-Lindau (VHL) interactome | journal = Journal of Proteome Research | volume = 10 | issue = 11 | pages = 5175–82 | date = November 2011 | pmid = 21942715 | pmc = 3208728 | doi = 10.1021/pr200642c }}
| last1 = Lai | first1 = Y.
* {{cite journal | vauthors = Topp JD, Jackson J, Melton AA, Lynch KW | title = A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4 | journal = RNA | volume = 14 | issue = 10 | pages = 2038–49 | date = October 2008 | pmid = 18719244 | pmc = 2553740 | doi = 10.1261/rna.1212008 }}
| last2 = Song | first2 = M.
* {{cite journal | vauthors = Wu Z, Yates AL, Hoyne GF, Goodnow CC | title = Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation | journal = Journal of Immunology | volume = 185 | issue = 1 | pages = 231–8 | date = July 2010 | pmid = 20505149 | pmc = | doi = 10.4049/jimmunol.0903625 }}
| last3 = Hakala | first3 = K.
* {{cite journal | vauthors = Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA | title = Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism | journal = Biochemical and Biophysical Research Communications | volume = 416 | issue = 3–4 | pages = 258–65 | date = December 2011 | pmid = 22079093 | pmc = | doi = 10.1016/j.bbrc.2011.10.126 }}
| last4 = Weintraub | first4 = S. T.
* {{cite journal | vauthors = Shur I, Ben-Avraham D, Benayahu D | title = Alternatively spliced isoforms of a novel stromal RNA regulating factor | journal = Gene | volume = 334 | pages = 113–21 | date = June 2004 | pmid = 15256261 | pmc = | doi = 10.1016/j.gene.2004.03.012 }}
| last5 = Shiio | first5 = Y.
| title = Proteomic Dissection of the von Hippel–Lindau (VHL) Interactome
| doi = 10.1021/pr200642c
| journal = Journal of Proteome Research  
| volume = 10  
| issue = 11  
| pages = 5175–5182
| year = 2011  
| pmid = 21942715  
| pmc =3208728  
}}
*{{Cite journal  
| last1 = Topp | first1 = J. D.
| last2 = Jackson | first2 = J.
| last3 = Melton | first3 = A. A.
| last4 = Lynch | first4 = K. W.
| title = A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4  
| doi = 10.1261/rna.1212008
| journal = RNA  
| volume = 14  
| issue = 10  
| pages = 2038–2049
| year = 2008  
| pmid = 18719244  
| pmc =2553740  
}}
*{{Cite journal  
| last1 = Wu | first1 = Z.
| last2 = Yates | first2 = A. L.
| last3 = Hoyne | first3 = G. F.
| last4 = Goodnow | first4 = C. C.
| title = Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation
| doi = 10.4049/jimmunol.0903625
| journal = The Journal of Immunology  
| volume = 185  
| issue = 1  
| pages = 231–238
| year = 2010  
| pmid = 20505149  
| pmc =  
}}
*{{Cite journal
| last1 = Oberdoerffer | first1 = S.
| last2 = Moita | first2 = L. F.
| last3 = Neems | first3 = D.
| last4 = Freitas | first4 = R. P.
| last5 = Hacohen | first5 = N.
| last6 = Rao | first6 = A.
| doi = 10.1126/science.1157610
| title = Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL
| journal = Science
| volume = 321
| issue = 5889
| pages = 686–691
| year = 2008
| pmid = 18669861
| pmc =2791692
}}
*{{Cite journal  
| last1 = Fedorova | first1 = O. A.
| last2 = Moiseeva | first2 = T. N.
| last3 = Nikiforov | first3 = A. A.
| last4 = Tsimokha | first4 = A. S.
| last5 = Livinskaya | first5 = V. A.
| last6 = Hodson | first6 = M.
| last7 = Bottrill | first7 = A.
| last8 = Evteeva | first8 = I. N.
| last9 = Ermolayeva | first9 = J. B.
| last10 = Kuznetzova | first10 = I. M.
| last11 = Turoverov | first11 = K. K.
| last12 = Eperon | first12 = I.
| last13 = Barlev | first13 = N. A.
| title = Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism  
| doi = 10.1016/j.bbrc.2011.10.126
| journal = Biochemical and Biophysical Research Communications  
| volume = 416  
| issue = 3–4  
| pages = 258–265
| year = 2011  
| pmid = 22079093  
| pmc =  
}}
*{{Cite journal  
| last1 = Shur | first1 = I.
| last2 = Ben-Avraham | first2 = D.
| last3 = Benayahu | first3 = D.
| title = Alternatively spliced isoforms of a novel stromal RNA regulating factor  
| doi = 10.1016/j.gene.2004.03.012
| journal = Gene  
| volume = 334  
| pages = 113–121
| year = 2004  
| pmid = 15256261  
| pmc =  
}}
 
{{refend}}
{{refend}}


Latest revision as of 01:16, 28 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.[1]

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.[2]

References

  1. ↑ "Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like".
  2. ↑ Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A (August 2008). "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–91. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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