Revision as of 18:07, 15 September 2017 by en>Adc43210(1) HNF1B is protein not a factor. 2) HNF1B is NOT liver specific. According to NCBI gene https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=6928), the HNF1B is most highly expressed in kidney.)
TCF2 encodes transcription factor 2, a protein of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.[1]
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