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{{Infobox_gene}}
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'''Non-histone chromosomal protein HMG-14''' is a [[protein]] that in humans is encoded by the ''HMGN1'' [[gene]].<ref name="pmid3782107">{{cite journal | vauthors = Landsman D, Srikantha T, Westermann R, Bustin M | title = Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family | journal = The Journal of Biological Chemistry | volume = 261 | issue = 34 | pages = 16082-6 | date = Dec 1986 | pmid = 3782107 | pmc =  | doi =  }}</ref><ref name="pmid2563381">{{cite journal | vauthors = Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M | title = Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family | journal = The Journal of Biological Chemistry | volume = 264 | issue = 6 | pages = 3421-7 | date = Feb 1989 | pmid = 2563381 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3150| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = High-mobility group nucleosome binding domain 1
| HGNCid = 4984
| Symbol = HMGN1
| AltSymbols =; FLJ27265; FLJ31471; HMG14; MGC104230; MGC117425
| OMIM = 163920
| ECnumber = 
| Homologene = 3643
| MGIid = 96120
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0008159 |text = positive transcription elongation factor activity}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3150
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_004956
    | Hs_RefseqmRNA = NM_004965
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 15312
    | Mm_Ensembl = ENSMUSG00000040681
    | Mm_RefseqmRNA = NM_008251
    | Mm_RefseqProtein = NP_032277
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 96225528
    | Mm_GenLoc_end = 96232639
    | Mm_Uniprot = P18608
  }}
}}
'''High-mobility group nucleosome binding domain 1''', also known as '''HMGN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3150| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.<ref name="pmid26709929">{{cite journal | vauthors = Martínez de Paz A, Ausió J | title = HMGNs: The enhancer charmers | journal = BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology | volume = 38 | issue = 3 | pages = 226–31 | year = 2016 | pmid = 26709929 | doi = 10.1002/bies.201500157 }}</ref> Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3150| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
HMGN1 has been shown to [[Protein-protein interaction|interact]] with [[YWHAZ]].<ref name=pmid12215538>{{cite journal | vauthors = Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M | title = Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6809-19 | date = Oct 2002 | pmid = 12215538 | pmc = 134047 | doi = 10.1128/MCB.22.19.6809-6819.2002 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Pash J, Popescu N, Matocha M, Rapoport S, Bustin M | title = Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 10 | pages = 3836-40 | date = May 1990 | pmid = 2140193 | pmc = 53998 | doi = 10.1073/pnas.87.10.3836 }}
| citations =
* {{cite journal | vauthors = Leffak M, Trempe JP | title = Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus | journal = Nucleic Acids Research | volume = 13 | issue = 13 | pages = 4853-69 | date = Jul 1985 | pmid = 4022776 | pmc = 321831 | doi = 10.1093/nar/13.13.4853 }}
*{{cite journal | author=Pash J, Popescu N, Matocha M, ''et al.'' |title=Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 10 |pages= 3836-40 |year= 1990 |pmid= 2140193 |doi=  }}
* {{cite journal | vauthors = Postnikov YV, Trieschmann L, Rickers A, Bustin M | title = Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores | journal = Journal of Molecular Biology | volume = 252 | issue = 4 | pages = 423-32 | date = Sep 1995 | pmid = 7563062 | doi = 10.1006/jmbi.1995.0508 }}
*{{cite journal  | author=Landsman D, McBride OW, Soares N, ''et al.'' |title=Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family. |journal=J. Biol. Chem. |volume=264 |issue= 6 |pages= 3421-7 |year= 1989 |pmid= 2563381 |doi= }}
* {{cite journal | vauthors = Ding HF, Rimsky S, Batson SC, Bustin M, Hansen U | title = Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14 | journal = Science | volume = 265 | issue = 5173 | pages = 796-9 | date = Aug 1994 | pmid = 8047885 | doi = 10.1126/science.8047885 }}
*{{cite journal  | author=Landsman D, Srikantha T, Westermann R, Bustin M |title=Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family. |journal=J. Biol. Chem. |volume=261 |issue= 34 |pages= 16082-6 |year= 1987 |pmid= 3782107 |doi=  }}
* {{cite journal | vauthors = Pash JM, Alfonso PJ, Bustin M | title = Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation | journal = The Journal of Biological Chemistry | volume = 268 | issue = 18 | pages = 13632-8 | date = Jun 1993 | pmid = 8514795 | doi =  }}
*{{cite journal | author=Leffak M, Trempe JP |title=Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus. |journal=Nucleic Acids Res. |volume=13 |issue= 13 |pages= 4853-69 |year= 1985 |pmid= 4022776 |doi= }}
* {{cite journal | vauthors = Bustin M, Alfonso PJ, Pash JM, Ward JM, Gearhart JD, Reeves RH | title = Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin | journal = DNA and Cell Biology | volume = 14 | issue = 12 | pages = 997-1005 | date = Dec 1995 | pmid = 8534374 | doi = 10.1089/dna.1995.14.997 }}
*{{cite journal | author=Postnikov YV, Trieschmann L, Rickers A, Bustin M |title=Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores. |journal=J. Mol. Biol. |volume=252 |issue= 4 |pages= 423-32 |year= 1995 |pmid= 7563062 |doi= 10.1006/jmbi.1995.0508 }}
* {{cite journal | vauthors = Hock R, Scheer U, Bustin M | title = Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport | journal = The Journal of Cell Biology | volume = 143 | issue = 6 | pages = 1427-36 | date = Dec 1998 | pmid = 9852141 | pmc = 2132996 | doi = 10.1083/jcb.143.6.1427 }}
*{{cite journal | author=Ding HF, Rimsky S, Batson SC, ''et al.'' |title=Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14. |journal=Science |volume=265 |issue= 5173 |pages= 796-9 |year= 1994 |pmid= 8047885 |doi= }}
* {{cite journal | vauthors = Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG | title = Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry | journal = Protein Science | volume = 9 | issue = 1 | pages = 170-9 | date = Jan 2000 | pmid = 10739259 | pmc = 2144438 | doi = 10.1110/ps.9.1.170 }}
*{{cite journal | author=Pash JM, Alfonso PJ, Bustin M |title=Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation. |journal=J. Biol. Chem. |volume=268 |issue= 18 |pages= 13632-8 |year= 1993 |pmid= 8514795 |doi=  }}
* {{cite journal | vauthors = Bergel M, Herrera JE, Thatcher BJ, Prymakowska-Bosak M, Vassilev A, Nakatani Y, Martin B, Bustin M | title = Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes | journal = The Journal of Biological Chemistry | volume = 275 | issue = 15 | pages = 11514-20 | date = Apr 2000 | pmid = 10753971 | doi = 10.1074/jbc.275.15.11514 }}
*{{cite journal | author=Bustin M, Alfonso PJ, Pash JM, ''et al.'' |title=Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin. |journal=DNA Cell Biol. |volume=14 |issue= 12 |pages= 997-1005 |year= 1996 |pmid= 8534374 |doi= }}
* {{cite journal | vauthors = Prymakowska-Bosak M, Misteli T, Herrera JE, Shirakawa H, Birger Y, Garfield S, Bustin M | title = Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin | journal = Molecular and Cellular Biology | volume = 21 | issue = 15 | pages = 5169-78 | date = Aug 2001 | pmid = 11438671 | pmc = 87241 | doi = 10.1128/MCB.21.15.5169-5178.2001 }}
*{{cite journal | author=Hock R, Scheer U, Bustin M |title=Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport. |journal=J. Cell Biol. |volume=143 |issue= 6 |pages= 1427-36 |year= 1999 |pmid= 9852141 |doi= }}
* {{cite journal | vauthors = Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M | title = Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6809-19 | date = Oct 2002 | pmid = 12215538 | pmc = 134047 | doi = 10.1128/MCB.22.19.6809-6819.2002 }}
*{{cite journal | author=Louie DF, Gloor KK, Galasinski SC, ''et al.'' |title=Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. |journal=Protein Sci. |volume=9 |issue= 1 |pages= 170-9 |year= 2000 |pmid= 10739259 |doi= }}
* {{cite journal | vauthors = Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS | title = MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 | journal = The EMBO Journal | volume = 22 | issue = 11 | pages = 2788-97 | date = Jun 2003 | pmid = 12773393 | pmc = 156769 | doi = 10.1093/emboj/cdg273 }}
*{{cite journal | author=Bergel M, Herrera JE, Thatcher BJ, ''et al.'' |title=Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11514-20 |year= 2000 |pmid= 10753971 |doi= }}
* {{cite journal | vauthors = Zou Y, Jiang X, Wang Y | title = Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells | journal = Biochemistry | volume = 43 | issue = 20 | pages = 6322-9 | date = May 2004 | pmid = 15147216 | doi = 10.1021/bi0362828 }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130-5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Prymakowska-Bosak M, Misteli T, Herrera JE, ''et al.'' |title=Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5169-78 |year= 2001 |pmid= 11438671 |doi= 10.1128/MCB.21.15.5169-5178.2001 }}
*{{cite journal | author=Prymakowska-Bosak M, Hock R, Catez F, ''et al.'' |title=Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 19 |pages= 6809-19 |year= 2002 |pmid= 12215538 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Soloaga A, Thomson S, Wiggin GR, ''et al.'' |title=MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2788-97 |year= 2003 |pmid= 12773393 |doi= 10.1093/emboj/cdg273 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Zou Y, Jiang X, Wang Y |title=Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells. |journal=Biochemistry |volume=43 |issue= 20 |pages= 6322-9 |year= 2004 |pmid= 15147216 |doi= 10.1021/bi0362828 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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Revision as of 13:53, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.[1][2][3]

Function

Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation.[4] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[3]

Interactions

HMGN1 has been shown to interact with YWHAZ.[5]

References

  1. ↑ Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family". The Journal of Biological Chemistry. 261 (34): 16082–6. PMID 3782107.
  2. ↑ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family". The Journal of Biological Chemistry. 264 (6): 3421–7. PMID 2563381.
  3. ↑ 3.0 3.1 "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1".
  4. ↑ Martínez de Paz A, Ausió J (2016). "HMGNs: The enhancer charmers". BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 38 (3): 226–31. doi:10.1002/bies.201500157. PMID 26709929.
  5. ↑ Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Molecular and Cellular Biology. 22 (19): 6809–19. doi:10.1128/MCB.22.19.6809-6819.2002. PMC 134047. PMID 12215538.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=HMGN1&oldid=1419817"