HLA-DQB1
| Major histocompatibility complex, class II, DQ beta 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | HLA-DQB1 ; CELIAC1; HLA-DQB; IDDM1 | ||||||||||
| External IDs | Template:OMIM5 | ||||||||||
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| RNA expression pattern | |||||||||||
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| File:PBB GE HLA-DQB1 211656 x at tn.png | |||||||||||
| File:PBB GE HLA-DQB1 212998 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene.
HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.[1]
See also
References
Further reading
- Todd JA (1990). "Genetic control of autoimmunity in type 1 diabetes". Immunol. Today. 11 (4): 122–9. PMID 2187469.
- Lau M, Terasaki PI, Park MS (1995). "International Cell Exchange, 1994". Clinical transplants: 467–88. PMID 7547576.
- Todd JA (1997). "Genetics of type 1 diabetes". Pathol. Biol. 45 (3): 219–27. PMID 9296067.
- Schmidt H, Williamson D, Ashley-Koch A (2007). "HLA-DR15 haplotype and multiple sclerosis: a HuGE review". Am. J. Epidemiol. 165 (10): 1097–109. doi:10.1093/aje/kwk118. PMID 17329717.