HLA-A26
major histocompatibility complex (human), class I, A26
| ||
| Alleles | A*2601 A*2602 A*2603 A*2605 | |
| Structure (See HLA-A) | ||
| Identifiers | 2601 2602 2603 2605
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*2601 | |
| EBI-HLA | A*2602 | |
| EBI-HLA | A*2603 | |
| EBI-HLA | A*2605 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A26 (A26) is an HLA-A serotype. The serotype identifies the more common HLA-A*26 gene products. A26 is a split antigen of the A10 broad antigen serotype group. A*2601 is believed to be the ancestral type for the A10 group, this group also includes A25, A34, A43 and A66.[1] A26 is broadly distributed but A26 is unusually common in Japan with a number of variants.
Serotype
| A*26 | A26 | A10 | Sample |
| allele | % | % | size (N) |
| 2601 | 97 | 2 | 1730 |
| 2602 | 81 | 31 | |
| 2603 | 68 | 8 | 38 |
| 2605 | 90 | 10 |
Serotype recognition of most alleles is generally good.
Disease associations
A26 Serotype is associated with adult T-cell leukemia in Japanese.[2][3]
References
- ↑ derived from IMGT/HLA
- ↑ Nomura K, Utsunomiya A, Furushou H, Tara M, Hazeki M, Tokunaga M, Uozumi K, Hanada S, Yashiki S, Tajima K, Sonoda S (2006). "A family predisposition to adult T-cell leukemia". J Clin Exp Hematop. 46 (2): 67–71. PMID 17142956.
- ↑ Yashiki S, Fujiyoshi T, Arima N, Osame M, Yoshinaga M, Nagata Y, Tara M, Nomura K, Utsunomiya A, Hanada S, Tajima K, Sonoda S (2001). "HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes". AIDS Res Hum Retroviruses. 17 (11): 1047–61. PMID 11485622.