HDAC1

Histone deacetylase 1
Identifiers
Symbols	HDAC1 ; DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68426
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Histone deacetylase 1, also known as HDAC1, is a human gene.

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

See also

• Histone deacetylase

Further reading

• Wolffe AP (1996). "Histone deacetylase: a regulator of transcription". Science. 272 (5260): 371–2. PMID 8602525.
• Ahringer J (2000). "NuRD and SIN3 histone deacetylase complexes in development". Trends Genet. 16 (8): 351–6. PMID 10904264.
• Verdin E, Dequiedt F, Kasler HG (2003). "Class II histone deacetylases: versatile regulators". Trends Genet. 19 (5): 286–93. PMID 12711221.CS1 maint: Multiple names: authors list (link)
• Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". J. Steroid Biochem. Mol. Biol. 85 (2–5): 401–14. PMID 12943729.
• Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMID 16838299.CS1 maint: Multiple names: authors list (link)
• Hijmans EM, Voorhoeve PM, Beijersbergen RL; et al. (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. 15 (6): 3082–9. PMID 7760804.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Margolis DM, Somasundaran M, Green MR (1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". J. Virol. 68 (2): 905–10. PMID 8289393.CS1 maint: Multiple names: authors list (link)
• Taunton J, Hassig CA, Schreiber SL (1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". Science. 272 (5260): 408–11. PMID 8602529.CS1 maint: Multiple names: authors list (link)
• Furukawa Y, Kawakami T, Sudo K; et al. (1996). "Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae". Cytogenet. Cell Genet. 73 (1–2): 130–3. PMID 8646880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hassig CA, Fleischer TC, Billin AN; et al. (1997). "Histone deacetylase activity is required for full transcriptional repression by mSin3A". Cell. 89 (3): 341–7. PMID 9150133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laherty CD, Yang WM, Sun JM; et al. (1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell. 89 (3): 349–56. PMID 9150134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Iratni R, Erdjument-Bromage H; et al. (1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. PMID 9150135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Romerio F, Gabriel MN, Margolis DM (1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". J. Virol. 71 (12): 9375–82. PMID 9371597.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brehm A, Miska EA, McCance DJ; et al. (1998). "Retinoblastoma protein recruits histone deacetylase to repress transcription". Nature. 391 (6667): 597–601. doi:10.1038/35404. PMID 9468139.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magnaghi-Jaulin L, Groisman R, Naguibneva I; et al. (1998). "Retinoblastoma protein represses transcription by recruiting a histone deacetylase". Nature. 391 (6667): 601–5. doi:10.1038/35410. PMID 9468140.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin RJ, Nagy L, Inoue S; et al. (1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–4. doi:10.1038/35895. PMID 9486654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo RX, Postigo AA, Dean DC (1998). "Rb interacts with histone deacetylase to repress transcription". Cell. 92 (4): 463–73. PMID 9491888.CS1 maint: Multiple names: authors list (link)

External links

• HDAC1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)