Guillain-Barré syndrome pathophysiology: Difference between revisions

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=== Physiology ===
=== Physiology ===
* Soma is the neuronal cell body which is a closed area with cell membrane.
* Dendrites are branched processes which lead the impulse into the neuronal cell body.
* Axons in a single process which lead the impulse away from the neuronal cell body.
* Myelin sheath is the oligodendrocyte membrane which wraps around the axons.
* Myelin sheath is insulated against electrical impulses and is separated by nodes of ranvier which can transfer the electrical impulse.
* This structure leads to fast traveling of electrical impulses.<ref name=":0">{{cite book | last = Mattle | first = Heinrich | title = Fundamentals of neurology : an illustrated guide | publisher = Thieme | location = Stuttgart New York | year = 2017 | isbn = 9783131364524 }}</ref>


=== Pathogenesis ===
=== Pathogenesis ===

Revision as of 20:02, 14 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

Pathophysiology

Physiology

  • Soma is the neuronal cell body which is a closed area with cell membrane.
  • Dendrites are branched processes which lead the impulse into the neuronal cell body.
  • Axons in a single process which lead the impulse away from the neuronal cell body.
  • Myelin sheath is the oligodendrocyte membrane which wraps around the axons.
  • Myelin sheath is insulated against electrical impulses and is separated by nodes of ranvier which can transfer the electrical impulse.
  • This structure leads to fast traveling of electrical impulses.[1]

Pathogenesis

  • The exact pathogenesis of [disease name] is not completely understood.

OR

  • It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
  • [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
  • Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
  • [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
  • The progression to [disease name] usually involves the [molecular pathway].
  • The pathophysiology of [disease/malignancy] depends on the histological subtype.

Genetics

[Disease name] is transmitted in [mode of genetic transmission] pattern.

OR

Genes involved in the pathogenesis of [disease name] include:

  • [Gene1]
  • [Gene2]
  • [Gene3]

OR

The development of [disease name] is the result of multiple genetic mutations such as:

  • [Mutation 1]
  • [Mutation 2]
  • [Mutation 3]

Associated Conditions

Conditions associated with [disease name] include:

  • [Condition 1]
  • [Condition 2]
  • [Condition 3]

Gross Pathology

On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

Microscopic Pathology

On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

References

  1. Mattle, Heinrich (2017). Fundamentals of neurology : an illustrated guide. Stuttgart New York: Thieme. ISBN 9783131364524.

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