Guillain-Barré syndrome other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

Nerve conduction studies and needle electromyography may be helpful in the diagnosis of Guillain Barre syndrome and differentiating various sub types. Findings diagnostic of demyelinating forms of Guillain Barre syndrome include: Reduced conduction velocity of motor nerves, increased distal motor latency, increased latency of F wave, conduction block and Temporal scattering. Findings diagnostic of axonal forms of Guillain Barre syndrome include: Reduced amplitude of distal motor and/or sensory nerve impulses and conduction block of motor nerves.

Other Diagnostic Studies

  • Nerve conduction studies and needle electromyography may be helpful in the diagnosis of Guillain Barre syndrome and differentiating various sub types.
  • Findings diagnostic of Guillain Barre syndrome include:[1][2][3]
    • In demyelinating forms:
      • Reduced conduction velocity of motor nerves.
      • Increased distal motor latency.
      • Increased latency of F wave.
      • conduction block
      • Temporal scattering
    • In axonal forms:
      • Reduced amplitude of distal motor and/or sensory nerve impulses.
      • Conduction block of motor nerves.

References

  1. Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV (November 1998). "Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group". Ann. Neurol. 44 (5): 780–8. doi:10.1002/ana.410440512. PMID 9818934.
  2. Kokubun N, Nishibayashi M, Uncini A, Odaka M, Hirata K, Yuki N (October 2010). "Conduction block in acute motor axonal neuropathy". Brain. 133 (10): 2897–908. doi:10.1093/brain/awq260. PMID 20855419.
  3. Willison HJ, Jacobs BC, van Doorn PA (August 2016). "Guillain-Barré syndrome". Lancet. 388 (10045): 717–27. doi:10.1016/S0140-6736(16)00339-1. PMID 26948435.

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