Guillain-Barré syndrome natural history, complications, and prognosis: Difference between revisions

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=== Natural history ===
=== Natural history ===
* The symptoms of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection.
* The [[Symptom|symptoms]] of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection.
* If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent disability.
* If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent [[disability]].
* 35% of them will not fully recover. 8% of these 35% will die from complication and others will have permanent disabilities.
* 35% of them will not fully recover. 8% of these 35% will die from [[Complications|complication]] and others will have permanent [[Disability|disabilities]].
* Treatment will just reduce the recovery period and has no effect on natural history of the disease.
* Treatment will just reduce the recovery period and has no effect on natural history of the disease.
* The first symptoms are lower extremities weakness and paresthesia.<ref name="pmid9818934">{{cite journal |vauthors=Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV |title=Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group |journal=Ann. Neurol. |volume=44 |issue=5 |pages=780–8 |date=November 1998 |pmid=9818934 |doi=10.1002/ana.410440512 |url=}}</ref><ref name="pmid1565119">{{cite journal |vauthors=Bradshaw DY, Jones HR |title=Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis |journal=Muscle Nerve |volume=15 |issue=4 |pages=500–6 |date=April 1992 |pmid=1565119 |doi=10.1002/mus.880150415 |url=}}</ref><ref name=":0">{{cite book | last = Mattle | first = Heinrich | title = Fundamentals of neurology : an illustrated guide | publisher = Thieme | location = Stuttgart New York | year = 2017 | isbn = 9783131364524 }}</ref>
* The first [[Symptom|symptoms]] are lower extremities [[weakness]] and [[paresthesia]].<ref name="pmid9818934">{{cite journal |vauthors=Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV |title=Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group |journal=Ann. Neurol. |volume=44 |issue=5 |pages=780–8 |date=November 1998 |pmid=9818934 |doi=10.1002/ana.410440512 |url=}}</ref><ref name="pmid1565119">{{cite journal |vauthors=Bradshaw DY, Jones HR |title=Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis |journal=Muscle Nerve |volume=15 |issue=4 |pages=500–6 |date=April 1992 |pmid=1565119 |doi=10.1002/mus.880150415 |url=}}</ref><ref name=":0">{{cite book | last = Mattle | first = Heinrich | title = Fundamentals of neurology : an illustrated guide | publisher = Thieme | location = Stuttgart New York | year = 2017 | isbn = 9783131364524 }}</ref>
===Complications===
===Complications===
* Common complications of GBS include:<ref name="pmid15668421">{{cite journal |vauthors=Dornonville de la Cour C, Jakobsen J |title=Residual neuropathy in long-term population-based follow-up of Guillain-Barré syndrome |journal=Neurology |volume=64 |issue=2 |pages=246–53 |date=January 2005 |pmid=15668421 |doi=10.1212/01.WNL.0000149521.65474.83 |url=}}</ref><ref name="pmid9344309">{{cite journal |vauthors=Meythaler JM |title=Rehabilitation of Guillain-Barré syndrome |journal=Arch Phys Med Rehabil |volume=78 |issue=8 |pages=872–9 |date=August 1997 |pmid=9344309 |doi= |url=}}</ref>
* Common complications of GBS include:<ref name="pmid15668421">{{cite journal |vauthors=Dornonville de la Cour C, Jakobsen J |title=Residual neuropathy in long-term population-based follow-up of Guillain-Barré syndrome |journal=Neurology |volume=64 |issue=2 |pages=246–53 |date=January 2005 |pmid=15668421 |doi=10.1212/01.WNL.0000149521.65474.83 |url=}}</ref><ref name="pmid9344309">{{cite journal |vauthors=Meythaler JM |title=Rehabilitation of Guillain-Barré syndrome |journal=Arch Phys Med Rehabil |volume=78 |issue=8 |pages=872–9 |date=August 1997 |pmid=9344309 |doi= |url=}}</ref>
** [[respiratory failure]]
** [[respiratory failure]]
** Autonomic failure
** [[Autonomic dysfunction|Autonomic failure]]
** Bulbar pulsy
** Bulbar pulsy
** [[Deep vein thrombosis]]
** [[Deep vein thrombosis]]
** Cardiac arrhythmia
** [[Cardiac arrhythmia]]
** Pain
** [[Pain]]
** Urinary retention
** [[Urinary retention]]
** Ileus
** [[Ileus]]
** Persistent fatigue
** Persistent [[fatigue]]


===Prognosis===
===Prognosis===
* About 65% of patients with GBS will fully recover with no permanent disability.
* About 65% of patients with GBS will fully recover with no permanent [[disability]].
* 35% of them do not fully recover. 8% of this group will die from GBS complication and others will have permanent disabilities.
* 35% of them do not fully recover. 8% of this group will die from GBS [[complication]] and others will have permanent [[Disability|disabilities]].
* Treatment of GBS just reduce the recovery time and doesn’t affect prognosis.<ref name="pmid9436731">{{cite journal |vauthors=Rees JH, Thompson RD, Smeeton NC, Hughes RA |title=Epidemiological study of Guillain-Barré syndrome in south east England |journal=J. Neurol. Neurosurg. Psychiatry |volume=64 |issue=1 |pages=74–7 |date=January 1998 |pmid=9436731 |pmc=2169900 |doi= |url=}}</ref>
* Treatment of GBS just reduce the recovery time and doesn’t affect [[prognosis]].<ref name="pmid9436731">{{cite journal |vauthors=Rees JH, Thompson RD, Smeeton NC, Hughes RA |title=Epidemiological study of Guillain-Barré syndrome in south east England |journal=J. Neurol. Neurosurg. Psychiatry |volume=64 |issue=1 |pages=74–7 |date=January 1998 |pmid=9436731 |pmc=2169900 |doi= |url=}}</ref>
* Overally, older patients will have worst prognosis in comparison to children who discover very fast.<ref name="pmid9818934">{{cite journal |vauthors=Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV |title=Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group |journal=Ann. Neurol. |volume=44 |issue=5 |pages=780–8 |date=November 1998 |pmid=9818934 |doi=10.1002/ana.410440512 |url=}}</ref><ref name="pmid1565119">{{cite journal |vauthors=Bradshaw DY, Jones HR |title=Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis |journal=Muscle Nerve |volume=15 |issue=4 |pages=500–6 |date=April 1992 |pmid=1565119 |doi=10.1002/mus.880150415 |url=}}</ref>
* Overally, older patients will have worst prognosis in comparison to children who discover very fast.<ref name="pmid9818934">{{cite journal |vauthors=Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV |title=Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group |journal=Ann. Neurol. |volume=44 |issue=5 |pages=780–8 |date=November 1998 |pmid=9818934 |doi=10.1002/ana.410440512 |url=}}</ref><ref name="pmid1565119">{{cite journal |vauthors=Bradshaw DY, Jones HR |title=Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis |journal=Muscle Nerve |volume=15 |issue=4 |pages=500–6 |date=April 1992 |pmid=1565119 |doi=10.1002/mus.880150415 |url=}}</ref>


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Fahimeh Shojaei, M.D.

Overview

Natural History, Complications, and Prognosis

Natural history

  • The symptoms of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection.
  • If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent disability.
  • 35% of them will not fully recover. 8% of these 35% will die from complication and others will have permanent disabilities.
  • Treatment will just reduce the recovery period and has no effect on natural history of the disease.
  • The first symptoms are lower extremities weakness and paresthesia.[1][2][3]

Complications

Prognosis

  • About 65% of patients with GBS will fully recover with no permanent disability.
  • 35% of them do not fully recover. 8% of this group will die from GBS complication and others will have permanent disabilities.
  • Treatment of GBS just reduce the recovery time and doesn’t affect prognosis.[6]
  • Overally, older patients will have worst prognosis in comparison to children who discover very fast.[1][2]

References

  1. ↑ 1.0 1.1 Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV (November 1998). "Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group". Ann. Neurol. 44 (5): 780–8. doi:10.1002/ana.410440512. PMID 9818934.
  2. ↑ 2.0 2.1 Bradshaw DY, Jones HR (April 1992). "Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis". Muscle Nerve. 15 (4): 500–6. doi:10.1002/mus.880150415. PMID 1565119.
  3. ↑ Mattle, Heinrich (2017). Fundamentals of neurology : an illustrated guide. Stuttgart New York: Thieme. ISBN 9783131364524.
  4. ↑ Dornonville de la Cour C, Jakobsen J (January 2005). "Residual neuropathy in long-term population-based follow-up of Guillain-Barré syndrome". Neurology. 64 (2): 246–53. doi:10.1212/01.WNL.0000149521.65474.83. PMID 15668421.
  5. ↑ Meythaler JM (August 1997). "Rehabilitation of Guillain-Barré syndrome". Arch Phys Med Rehabil. 78 (8): 872–9. PMID 9344309.
  6. ↑ Rees JH, Thompson RD, Smeeton NC, Hughes RA (January 1998). "Epidemiological study of Guillain-Barré syndrome in south east England". J. Neurol. Neurosurg. Psychiatry. 64 (1): 74–7. PMC 2169900. PMID 9436731.

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