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{{Guillain-Barré syndrome}}
{{Guillain-Barré syndrome}}


{{CMG}}; '''Associate Editors-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, MBBS]] [mailto:psingh@perfuse.org]
{{CMG}}; {{AE}} [[Priyamvada Singh|Priyamvada Singh, MBBS]] [mailto:psingh13579@gmail.com]


==Overview==
==Overview==
'''Guillain-Barré syndrome''' ('''GBS''') is an acute, autoimmune, [[neuropathy|polyradiculoneuropathy]] affecting the [[peripheral nervous system]], usually triggered by an acute infectious process. It is included in the wider group of [[peripheral neuropathy|peripheral neuropathies]]. There are several types of GBS, but unless otherwise stated, GBS refers to the most common form, acute inflammatory demyelinating polyneuropathy (AIDP). It is frequently severe and usually exhibits as an ascending paralysis noted by weakness in the legs that spreads to the upper limbs and the face along with complete loss of deep tendon reflexes. With prompt treatment of [[plasmapheresis]] followed by [[immunoglobulins]] and supportive care, the majority of patients will regain full functional capacity. However, death may occur if severe pulmonary complications and [[dysautonomia]] are present.
The disease was first described by the French physician [[Jean Landry (physician)|Jean Landry]] in 1859. In 1916, [[Georges Guillain]], [[Jean Alexandre Barré]] and Andre Strohl diagnosed two soldiers with motor weakness, [[areflexia]] and a the key diagnostic abnormality of increased [[spinal fluid]] [[protein]] production, but normal cell count. Later, it was called Guillain-Barré syndrome after them. GBS is also known as [[acute inflammatory demyelinating polyneuropathy]], acute idiopathic polyradiculoneuritis, acute idiopathic polyneuritis, French Polio and Landry's ascending paralysis.
==Historical perspective==


* The disease was first described by the French physician Jean Landry in 1859.
==Historical Perspective==
* In 1916, Georges Guillain, Jean Alexandre Barré and Andre Strohl diagnosed two soldiers with motor weakness, areflexia and a the key diagnostic abnormality of increased spinal fluid protein production, but normal cell count.<ref>{{WhoNamedIt2|synd|1766|Guillain-Barré-Strohl syndrome}} and {{WhoNamedIt|synd|1508|Miller Fisher's syndrome}}</ref>. Later, it was called Guillain-Barré syndrome after them.
 
* GBS is also known as [[acute inflammatory demyelinating polyneuropathy]], [[acute idiopathic polyradiculoneuritis]], [[acute idiopathic polyneuritis]], [[French Polio]] and [[Landry's ascending paralysis]].
=== Discovery ===
* The disease was first described by the French physician [[Jean Landry (physician)|Jean Landry]] in 1859.
* In 1916, [[Georges Guillain]], [[Jean Alexandre Barré]] and Andre Strohl diagnosed two soldiers with motor weakness, [[areflexia]] and a the key diagnostic abnormality of increased [[spinal fluid]] [[protein]] production, but normal cell count.<ref>{{WhoNamedIt2|synd|1766|Guillain-Barré-Strohl syndrome}} and {{WhoNamedIt|synd|1508|Miller Fisher's syndrome}}</ref>. Later, it was called Guillain-Barré syndrome after them.
* GBS is also known as [[acute inflammatory demyelinating polyneuropathy]], acute idiopathic polyradiculoneuritis, acute idiopathic polyneuritis, French Polio and Landry's ascending paralysis.
 
==Famous Cases==
[[Image:Griffith, Andy (Whitehouse).jpg|thumb|American actor [[Andy Griffith]] developed Guillain-Barré syndrome in 1983. Griffith is seen here receiving an award at the White House in 2005]]
* Markus Babbel, former international [[association football|footballer]].<ref>{{Cite news|last=Wallace |first=Sam |url=http://www.telegraph.co.uk/sport/main.jhtml?xml=/sport/2002/08/10/sfnliv10.xml |title=Grateful Babbel a tower of strength again |publisher=Telegraph |date=2002-08-10 |accessdate=2009-11-23 | location=London}}</ref>
* Tony Benn, British politician.<ref>{{Cite news|url=http://www.timesonline.co.uk/tol/life_and_style/article824739.ece|title=Relative Values: Tony and Josh Benn|publisher=The Times|date=2002-10-17|accessdate=2009-01-15 | location=London|first=Robert|last=Lea}}</ref>
* Rachel Chagall, actress.<ref>{{Cite web|url=http://www.disabilityfilms.co.uk/general1/gabyatruestory.htm |title=Gaby, A True Story (1987) |work=Films involving Disabilities |accessdate=}}</ref>
* Samuel Goldstein, American athlete and Paralympian.<ref>[http://jta.org/news/article/2009/05/05/1004932/before-getting-the-swine-flu-vaccine-consider-sam-goldstein The case of Sam Goldstein and the swine flu vaccine], jta.org, May 5, 2009</ref>
* Andy Griffith, American actor.<ref>{{Cite web|url=http://www.mayberry.com/tagsrwc/wbmutbb/anewsome/private/guidpost.htm |title=Andy in Guideposts Magazine |work= |accessdate=}}</ref>
* Joseph Heller, author.<ref>{{Cite book|author=Vogel, Speed; Heller, Joseph |title=No Laughing Matter |publisher=Simon & Schuster |location=New York |year=2004 |pages= |isbn=0-7432-4717-5 |oclc= |doi= |accessdate= }}</ref>
* Luci Baines Johnson, daughter of President Lyndon Johnson and Lady Bird Johnson.<ref>{{Cite web|url=http://www.austin360.com/blogs/content/shared-gen/blogs/austin/outandabout/entries/2010/04/17/luci_baines_joh.html|title=Luci Baines Johnson hospitalized with nervous system disorder | accessdate= }}</ref>
* Hugh McElhenny, American football player.<ref>{{Cite news|url=http://www.seattlepi.com/huskies/189001_hugh02.html |title=The untold story of Hugh McElhenny, the King of Montlake|publisher=Seattle PI|date=2004-09-02|accessdate=2010-01-07|first1=Dan|last1=Raley}}</ref>
* Lucky Oceans, Grammy Award-winning musician.<ref>{{Cite news|url=http://www.theaustralian.news.com.au/story/0,,24485771-22822,00.html |title=Lucky Oceans in hospital|publisher=[[The Australian]]|date=2008-10-13|accessdate=2008-10-28}}</ref>
* Len Pasquarelli, sports writer and analyst for ESPN and resident of the Pro Football Writers of America.<ref>{{Cite news|url=http://sports.espn.go.com/nfl/playoffs2008/columns/story?id=3861360 |title=Chris Mortensen on Len Pasquarelli's comeback|publisher=ESPN.com|date=2009-01-26|accessdate=2009-01-26}}</ref>
* Serge Payer, Canadian-born professional hockey player.<ref>Serge Payer Foundation, [http://www.sergepayerfoundation.org/Mission.html ''Serge Payer Foundation Mission''].</ref>
* William “The Refrigerator” Perry, former professional American football player.<ref>{{Cite news|url=http://www.yumasun.com/sports/tatum_44249___article.html/perry_night.html|title=|publisher=YumaSun.com|date=2008-09-08|accessdate=2008-10-28}}</ref>
* Franklin D. Roosevelt, U.S. president.<ref name="Goldman">{{Cite journal|author=Goldman AS, Schmalstieg EJ, Freeman DH, Goldman DA, Schmalstieg FC |title=What was the cause of Franklin Delano Roosevelt's paralytic illness? |journal=J Med Biogr |volume=11 |issue=4 |pages=232–40 |year=2003 |pmid=14562158 |url=http://www.rsmpress.co.uk/jmb_2003_v11_p232-240.pdf |doi= |accessdate=2010-08-07 |format=PDF }}</ref>
* Norton Simon, American industrialist and philanthropist.<ref>{{Cite web|title = Norton Simon Biography | url = http://www.nortonsimon.org/about/biography.aspx | accessdate = 13 October 2009}}</ref>
* Hans Vonk, Dutch conductor.<ref>{{Cite news|url=http://www.nytimes.com/2004/08/31/arts/hans-vonk-63-conductor-of-the-st-louis-symphony.html |title=Hans Vonk, 63, Conductor Of the St. Louis Symphony|publisher=The New York Times|date=2004-08-31|accessdate=2009-08-26 | first=Allan | last=Kozinn}}</ref>
* Danny Wuerffel, 1996 Heisman Trophy winner.<ref>{{cite web|last=Dooley|first=Pat|title=Wuerffel hospitalized to treat nervous system disorder|url=http://www.gatorsports.com/article/20110615/ARTICLES/110619738|publisher=Gatorsports.com|accessdate=16 June 2011}}</ref>


==References==
==References==
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[[Category:Autoimmune diseases]]
[[Category:Autoimmune diseases]]
[[Category:Neurological disorders]]
[[Category:Neurological disorders]]
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[[Category:Neurology]]
[[Category:Immunology]]
[[Category:Immunology]]
[[Category:Syndromes]]
[[Category:Overview complete]]
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[[Category:Emergency medicine]]
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Latest revision as of 05:06, 2 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyamvada Singh, MBBS [2]

Overview

The disease was first described by the French physician Jean Landry in 1859. In 1916, Georges Guillain, Jean Alexandre Barré and Andre Strohl diagnosed two soldiers with motor weakness, areflexia and a the key diagnostic abnormality of increased spinal fluid protein production, but normal cell count. Later, it was called Guillain-Barré syndrome after them. GBS is also known as acute inflammatory demyelinating polyneuropathy, acute idiopathic polyradiculoneuritis, acute idiopathic polyneuritis, French Polio and Landry's ascending paralysis.

Historical Perspective

Discovery

Famous Cases

File:Griffith, Andy (Whitehouse).jpg
American actor Andy Griffith developed Guillain-Barré syndrome in 1983. Griffith is seen here receiving an award at the White House in 2005
  • Markus Babbel, former international footballer.[2]
  • Tony Benn, British politician.[3]
  • Rachel Chagall, actress.[4]
  • Samuel Goldstein, American athlete and Paralympian.[5]
  • Andy Griffith, American actor.[6]
  • Joseph Heller, author.[7]
  • Luci Baines Johnson, daughter of President Lyndon Johnson and Lady Bird Johnson.[8]
  • Hugh McElhenny, American football player.[9]
  • Lucky Oceans, Grammy Award-winning musician.[10]
  • Len Pasquarelli, sports writer and analyst for ESPN and resident of the Pro Football Writers of America.[11]
  • Serge Payer, Canadian-born professional hockey player.[12]
  • William “The Refrigerator” Perry, former professional American football player.[13]
  • Franklin D. Roosevelt, U.S. president.[14]
  • Norton Simon, American industrialist and philanthropist.[15]
  • Hans Vonk, Dutch conductor.[16]
  • Danny Wuerffel, 1996 Heisman Trophy winner.[17]

References

  1. ↑ Template:WhoNamedIt2 and Template:WhoNamedIt
  2. ↑ Wallace, Sam (2002-08-10). "Grateful Babbel a tower of strength again". London: Telegraph. Retrieved 2009-11-23.
  3. ↑ Lea, Robert (2002-10-17). "Relative Values: Tony and Josh Benn". London: The Times. Retrieved 2009-01-15.
  4. ↑ "Gaby, A True Story (1987)". Films involving Disabilities.
  5. ↑ The case of Sam Goldstein and the swine flu vaccine, jta.org, May 5, 2009
  6. ↑ "Andy in Guideposts Magazine".
  7. ↑ Vogel, Speed; Heller, Joseph (2004). No Laughing Matter. New York: Simon & Schuster. ISBN 0-7432-4717-5.
  8. ↑ "Luci Baines Johnson hospitalized with nervous system disorder".
  9. ↑ Raley, Dan (2004-09-02). "The untold story of Hugh McElhenny, the King of Montlake". Seattle PI. Retrieved 2010-01-07.
  10. ↑ "Lucky Oceans in hospital". The Australian. 2008-10-13. Retrieved 2008-10-28.
  11. ↑ "Chris Mortensen on Len Pasquarelli's comeback". ESPN.com. 2009-01-26. Retrieved 2009-01-26.
  12. ↑ Serge Payer Foundation, Serge Payer Foundation Mission.
  13. ↑ . YumaSun.com. 2008-09-08 http://www.yumasun.com/sports/tatum_44249___article.html/perry_night.html. Retrieved 2008-10-28. Missing or empty |title= (help)
  14. ↑ Goldman AS, Schmalstieg EJ, Freeman DH, Goldman DA, Schmalstieg FC (2003). "What was the cause of Franklin Delano Roosevelt's paralytic illness?" (PDF). J Med Biogr. 11 (4): 232–40. PMID 14562158. Retrieved 2010-08-07.
  15. ↑ "Norton Simon Biography". Retrieved 13 October 2009.
  16. ↑ Kozinn, Allan (2004-08-31). "Hans Vonk, 63, Conductor Of the St. Louis Symphony". The New York Times. Retrieved 2009-08-26.
  17. ↑ Dooley, Pat. "Wuerffel hospitalized to treat nervous system disorder". Gatorsports.com. Retrieved 16 June 2011.

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