Gonadoblastoma

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Articles

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Articles on Gonadoblastoma in N Eng J Med, Lancet, BMJ

Media

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Clinical Trials

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Guidelines / Policies / Govt

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Definitions

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Patient Resources / Community

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Symptoms of Gonadoblastoma

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Experimental / Informatics

List of terms related to Gonadoblastoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Your Name

Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3

Overview

Historical Perspective

  • Gonadoblastoma was first discovered by Scully, in 1953.

Pathophysiology

Causes

  • Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy.

Differentiating Gonadoblastoma from other Diseases

  • Gonadoblastoma must be differentiated from other diseases that cause ovarian tumors, such as:
  • Germinoma
  • Cystadenoma
  • Cystadenocarcinoma
  • Endometrioid tumor
  • Brenner tumor
  • Leydig cell tumor
  • Granulosa cell tumor
  • 17-Hydroxylase Deficiency Syndrome
  • 5-Alpha-Reductase Deficiency
  • Amenorrhea
  • Congenital Adrenal Hyperplasia
  • Genital Anomalies
  • Hypospadias
  • Pediatric Seminoma
  • Turner Syndrome
  • Meigs syndrome

Laboratory Findings

  • A chromosome analysis is diagnostic of Gonadoblastoma.

Imaging Findings

  • There are no [imaging study] findings associated with [disease name].
  • [Imaging study 1] is the imaging modality of choice for [disease name].
  • On [imaging study 1], [disease name] is characterized by [finding 1], [finding 2], and [finding 3].
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

  • [Disease name] may also be diagnosed using [diagnostic study name].
  • Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • There is no treatment for [disease name]; the mainstay of therapy is supportive care.
  • The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
  • [Medical therapy 1] acts by [mechanism of action1].
  • Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

  • Surgery is the mainstay of therapy for gonadoblastoma.
  • Surgical exploration via laparotomy and bilateral salpingo-oophorectomy (BSO) is the most common approach to the treatment of gonadoblastoma.

Prevention

  • There are no primary preventive measures available for [disease name].
  • Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
  • Once diagnosed and successfully treated, patients with [disease name] are followedup every [duration]. Followup testing includes [test 1], [test 2], and [test 3].

References