Glycerin: Difference between revisions

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|genericName=Glycerin
|genericName=Glycerin
|aOrAn=a
|aOrAn=a
|drugClass=Laxative
|drugClass=[[Laxative]]
|indicationType=treatment
|indicationType=treatment
|indication=constipation
|indication=[[constipation]]
|adverseReactions=rectal discomfort or a burning sensation, diarrhea
|adverseReactions=[[Rectal pain|rectal discomfort]] or a burning sensation, [[diarrhea]]




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|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>


* Content
 


<!--Adult Indications and Dosage-->
<!--Adult Indications and Dosage-->
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<!--FDA-Labeled Indications and Dosage (Adult)-->
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult=====Indications====
|fdaLIADAdult=====Indications====
relieves occasional constipation (irregularity)
* relieves occasional [[constipation]] (irregularity)
• generally produces bowel movement in 1/4 to 1 hour
* generally produces bowel movement in 1/4 to 1 hour


====Directions====
====Directions====
[[File:Glycerin dosage.png|none|400px]]
[[File:Glycerin dosage.png|none|400px]]


insert 1 suppository well up into rectum and retain for 15 minutes
* insert 1 [[suppository]] well up into [[rectum]] and retain for 15 minutes
• it need not melt to produce laxative action
* it need not melt to produce [[laxative]] action
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.


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<!--FDA-Labeled Indications and Dosage (Pediatric)-->
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed=====Indications====
|fdaLIADPed=====Indications====
relieves occasional constipation (irregularity)
* relieves occasional [[constipation]] (irregularity)
• generally produces bowel movement in 1/4 to 1 hour
* generally produces bowel movement in 1/4 to 1 hour


====Directions====
====Directions====
[[File:Glycerin dosage.png|none|400px]]
[[File:Glycerin dosage.png|none|400px]]


insert 1 suppository well up into rectum and retain for 15 minutes
* insert 1 [[suppository]] well up into [[rectum]] and retain for 15 minutes
• it need not melt to produce laxative action
* it need not melt to produce [[laxative]] action
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.


Line 52: Line 52:


<!--Contraindications-->
<!--Contraindications-->
|contraindications=
|contraindications=<!--Warnings-->
 
<!--Warnings-->
|warnings=* For rectal use only
|warnings=* For rectal use only
Do not use laxative products for longer than 1 week unless directed by a doctor
* Do not use [[laxative]] products for longer than 1 week unless directed by a doctor


Ask a doctor before use if you have
* Ask a doctor before use if you have
• stomach pain  
:* [[stomach pain]]
• nausea
:* [[nausea]]
• vomiting
:* [[vomiting]]
• noticed a sudden change in bowel habits that lasts over 2 weeks
:* noticed a sudden change in bowel habits that lasts over 2 weeks


When using this product you may have rectal discomfort or a burning sensation
* When using this product you may have rectal discomfort or a burning sensation


Stop use and ask a doctor if you have rectal bleeding or fail to have a bowel movement after use of a laxative. These could be signs of a serious condition.
* Stop use and ask a doctor if you have rectal bleeding or fail to have a bowel movement after use of a [[laxative]]. These could be signs of a serious condition.


<!--Adverse Reactions-->
<!--Adverse Reactions-->
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<!--Clinical Trials Experience-->
<!--Clinical Trials Experience-->
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
=====Body as a Whole=====
=====Cardiovascular=====
=====Digestive=====
=====Endocrine=====
=====Hematologic and Lymphatic=====
=====Metabolic and Nutritional=====
=====Musculoskeletal=====
=====Neurologic=====
=====Respiratory=====
=====Skin and Hypersensitivy Reactions=====
=====Special Senses=====
=====Urogenital=====
=====Miscellaneous=====






<!--Postmarketing Experience-->
<!--Postmarketing Experience-->
|postmarketing=rectal discomfort or a burning sensation, diarrhea
|postmarketing=* [[Rectal pain|rectal discomfort]] or a burning sensation, [[diarrhea]]
 
|drugInteractions=<!--Use in Specific Populations-->
|drugInteractions=
 
<!--Use in Specific Populations-->
|useInPregnancyFDA=* IF PREGNANT OR BREAST FEEDING
|useInPregnancyFDA=* IF PREGNANT OR BREAST FEEDING
ask a health professional before use.
* ask a health professional before use.
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''


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|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInNursing=* IF PREGNANT OR BREAST FEEDING
|useInNursing=* IF PREGNANT OR BREAST FEEDING
ask a health professional before use.
* ask a health professional before use.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
Line 161: Line 94:


<!--Administration and Monitoring-->
<!--Administration and Monitoring-->
|administration=* rectal
|administration=* [[rectal]]
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


* Description


<!--IV Compatibility-->
<!--IV Compatibility-->
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<!--Overdosage-->
<!--Overdosage-->
|overdose=* If swallowed, get medical help or contact a Poison Control Center right away.
|overdose=* If swallowed, get medical help or contact a Poison Control Center right away.
|drugBox=<!--Mechanism of Action-->
|drugBox={{Chembox2
| Watchedfields = changed
| verifiedrevid = 464392960
| Name = Glycerol
| ImageFile1 = Glycerin chem.png
| ImageName1 = Glycerol
| IUPACName = propane-1,2,3-triol
| OtherNames = glycerin<br/>glycerine<br/>propanetriol<br/>1,2,3-trihydroxypropane
| Section1={{Chembox Identifiers
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = PDC6A3C0OX
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00028
| InChI = 1/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
| InChIKey = PEDCQBHIVMGVHV-UHFFFAOYAF
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 692
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = PEDCQBHIVMGVHV-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 56-81-5
| PubChem = 753
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 733
| ATCCode_prefix = A06
| ATCCode_suffix = AG04
| ATC_Supplemental = {{ATC|A06|AX01}}, {{ATCvet|A16|QA03}}
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB04077
| ChEBI = 17522
| ChEBI_Ref = {{ebicite|correct|EBI}}
| SMILES = C(C(CO)O)O
  }}
| Section2 = {{Chembox Properties
| C=3| H=8| O=3
| Appearance = colorless liquid <br/> [[hygroscopic]]
| Odor = odorless
| Density = 1.261 g/cm<sup>3</sup>
| Viscosity = 1.412 Pa&middot;s<ref name="Viscosity of Glycerol and its Aqueous Solutions">{{cite doi|10.1021/ie50501a040}}</ref>
| MeltingPtC = 17.8
| BoilingPtC = 290
| Boiling_ref = <ref>{{cite book| editor = Lide, D. R. | title = CRC Handbook of Data on Organic Compounds | edition = 3rd | publisher = CRC Press | location = Boca Raton, FL | year = 1994 | page = 4386}}</ref>
| RefractIndex = 1.4746
| VaporPressure = 0.003 mmHg (50°C)<ref name=PGCH/>
| Solubility = miscible<ref name=PGCH/>
  }}
| Section7 = {{Chembox Hazards
| ExternalMSDS = [http://www.jtbaker.com/msds/englishhtml/g4774.htm JT Baker]
| NFPA-H = 0
| NFPA-F = 1
| NFPA-R = 0
| NFPA-S =
| FlashPt = {{convert|160|C|F K}} (closed cup)<br/> {{convert|176|C|F K}} (open cup)
| PEL = TWA 15 mg/m<sup>3</sup> (total) TWA 5 mg/m<sup>3</sup> (resp)<ref name=PGCH>{{PGCH|0302}}</ref>
| IDLH = N.D.<ref name=PGCH/>
| REL = None establisher<ref name=PGCH/>
  }}
}}
 
 
 
<!--Mechanism of Action-->
|mechAction=*  
|mechAction=*  


<!--Structure-->
<!--Structure-->
|structure=* ACTIVE INGREDIENT (IN EACH SUPPOSITORY)
|structure=* ACTIVE INGREDIENT (IN EACH SUPPOSITORY)
Glycerin, USP 2.1 grams
:* Glycerin, USP 2.1 grams
INACTIVE INGREDIENT
* INACTIVE INGREDIENT
purified water, sodium hydroxide, stearic acid
:* purified water, sodium hydroxide, stearic acid
 




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<!--How Supplied-->
<!--How Supplied-->
|howSupplied=*
|howSupplied=
|packLabel=
|packLabel=====PACKAGE LABEL.PRINCIPAL DISPLAY PANEL====
: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
: [[File:Glycerin PDP.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
 
====Ingredients and Appearance====
: [[File:Glycerin I n A.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
<!--Patient Counseling Information-->
<!--Patient Counseling Information-->
|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.
|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.
Line 206: Line 202:


<!--Brand Names-->
<!--Brand Names-->
|brandNames=* ®<ref>{{Cite web | title = | url = }}</ref>
|brandNames=* GLYCERIN®<ref>{{Cite web | title = Glycerin suppository | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=267300ec-7522-ce46-3fe5-48469b5100a9}}</ref>


<!--Look-Alike Drug Names-->
<!--Look-Alike Drug Names-->
|lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>
|lookAlike=There is limited information regarding the look alike drug names.
 
<!--Drug Shortage Status-->
|drugShortage=
|drugShortage=
}}
}}
{{PillImage
|fileName=No image.jpg
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
<!--Pill Image-->
<!--Label Display Image-->




Latest revision as of 16:26, 20 August 2015

Glycerin
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rabin Bista, M.B.B.S. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.
NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Glycerin is a Laxative that is FDA approved for the treatment of constipation. Common adverse reactions include rectal discomfort or a burning sensation, diarrhea.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

  • relieves occasional constipation (irregularity)
  • generally produces bowel movement in 1/4 to 1 hour

Directions

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Glycerin in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Glycerin in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

  • relieves occasional constipation (irregularity)
  • generally produces bowel movement in 1/4 to 1 hour

Directions

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Glycerin in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Glycerin in pediatric patients.

Contraindications

There is limited information regarding Glycerin Contraindications in the drug label.

Warnings

  • For rectal use only
  • Do not use laxative products for longer than 1 week unless directed by a doctor
  • Ask a doctor before use if you have
  • When using this product you may have rectal discomfort or a burning sensation
  • Stop use and ask a doctor if you have rectal bleeding or fail to have a bowel movement after use of a laxative. These could be signs of a serious condition.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Glycerin in the drug label.

Postmarketing Experience

Drug Interactions

There is limited information regarding Glycerin Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • IF PREGNANT OR BREAST FEEDING
  • ask a health professional before use.


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Glycerin in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Glycerin during labor and delivery.

Nursing Mothers

  • IF PREGNANT OR BREAST FEEDING
  • ask a health professional before use.

Pediatric Use

There is no FDA guidance on the use of Glycerin with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Glycerin with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Glycerin with respect to specific gender populations.

Race

There is no FDA guidance on the use of Glycerin with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Glycerin in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Glycerin in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Glycerin in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Glycerin in patients who are immunocompromised.

Administration and Monitoring

Administration

Monitoring

There is limited information regarding Monitoring of Glycerin in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Glycerin in the drug label.

Overdosage

  • If swallowed, get medical help or contact a Poison Control Center right away.

Pharmacology

Template:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox E numberTemplate:Chembox AppearanceTemplate:Chembox OdourTemplate:Chembox DensityTemplate:Chembox MeltingPtTemplate:Chembox BoilingPtTemplate:Chembox SolubilityInWaterTemplate:Chembox VaporPressureTemplate:Chembox RefractIndexTemplate:Chembox ViscosityTemplate:Chembox NFPATemplate:Chembox FlashPtTemplate:Chembox NIOSH (set)Template:Chembox Supplement
Template:Chembox header2 | Glycerol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG
UNII
Properties
C3H8O3
Molar mass 92.09 g·mol−1
Hazards
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Mechanism of Action

Structure

  • ACTIVE INGREDIENT (IN EACH SUPPOSITORY)
  • Glycerin, USP 2.1 grams
  • INACTIVE INGREDIENT
  • purified water, sodium hydroxide, stearic acid

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Glycerin in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Glycerin in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Glycerin in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Glycerin in the drug label.

How Supplied

There is limited information regarding Glycerin How Supplied in the drug label.

Storage

There is limited information regarding Glycerin Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Glycerin |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

This image is provided by the National Library of Medicine.

Ingredients and Appearance

This image is provided by the National Library of Medicine.

{{#ask: Label Page::Glycerin |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Glycerin in the drug label.

Precautions with Alcohol

  • Alcohol-Glycerin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

There is limited information regarding the look alike drug names.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Template:PGCH
  2. ↑ Template:Cite doi
  3. ↑ Lide, D. R., ed. (1994). CRC Handbook of Data on Organic Compounds (3rd ed.). Boca Raton, FL: CRC Press. p. 4386.
  4. ↑ "Glycerin suppository".
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