Glutathione: Difference between revisions

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|indicationType=treatment
|Section1= {{Chembox Identifiers
|indication=chronic [[fatigue]], muscle aches and pain
| CASNo=70-18-8
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* Content


<!--Adult Indications and Dosage-->


==Overview==
<!--FDA-Labeled Indications and Dosage (Adult)-->
'''Glutathione''' ('''GSH''') is a [[tripeptide]]. It contains an unusual [[peptide]] linkage between the [[amino acid|amine group]] of [[cysteine]] and the [[carboxyl]] group of the [[glutamate]] [[side chain]].  Glutathione, an [[antioxidant]], protects cells from toxins such as [[free radical]]s.<ref>{{cite journal
|fdaLIADAdult===Indications==
| author = Strużńka L, Chalimoniuk M, Sulkowski G.
* For temporary relief of chronic fatigue, muscle aches and pain, lowered immune response, and sensitivity to environmental chemicals.
| year = 2005
| month = September
| title = The role of astroglia in Pb-exposed adult rat brain with respect to glutamate toxicity
| journal = Toxicology
| volume = 212
| issue = 2-3
| pages = 185-194
| id = PMID 15955607
| accessdate = 2006-05-05
}}
</ref>


[[Thiol]] groups are kept in a [[redox|reduced]] state at a concentration of approximately ~5 mM in [[animal]] [[cell (biology)|cell]]s. In effect, glutathione reduces any [[disulfide bond]]s formed within [[cytoplasm]]ic [[protein]]s to [[cysteine]]s by acting as an [[electron]] donor. Glutathione is found almost exclusively in its reduced form, since the enzyme that reverts it from its oxidized form (GSSG), [[glutathione reductase]], is constitutively active and inducible upon [[oxidative stress]]. In fact, the ratio of reduced glutathione to oxidized glutathione within cells is often used scientifically as a measure of cellular toxicity.
==Dosage==
* 10 drops orally, 3 times a day.
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
|fdaLIADPed=There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
|contraindications=* Prior hypersensitivity to glutathione
|warnings=* If pregnant or breast-feeding, ask a health care professional before use.  


==Biosynthesis==
* Keep out of reach of children.  In case of overdose, get medical help or contact a Poison Control Center right away.
Glutathione is not an essential nutrient since it can be synthesized from the amino acids [[L-cysteine]], [[L-glutamate]] and [[glycine]].


It is synthesized in two [[adenosine triphosphate]]-dependent steps:
* Do not use if tamper evident seal is broken or missing. Store in a cool, dry place.
*First, gamma-glutamylcysteine is synthesized from L-glutamate and cysteine via the enzyme [[gamma-glutamylcysteine synthetase]] (a.k.a. glutamate cysteine ligase, GCL). This reaction is the rate-limiting step in glutathione synthesis.  
|clinicalTrials=* cutaneous eruptions
*Second, glycine is added to the C-terminal of gamma-glutamylcysteine via the enzyme [[glutathione synthetase]].
|postmarketing=There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''


Glutamate cysteine ligase (GCL) is a heterodimeric enzyme composed of a catalytic (GCLC) and modulatory (GCLM) subunit. GCLC constitutes all the enzymatic activity, whereas GCLM increases the catalytic efficiency of GCLC. Mice lacking GCLC (i.e., all de novo GSH synthesis) die before birth.<ref>{{Citation | last = Dalton | first = TP | last2 = et al. | year = 2000 | journal = Biochem Biophys Res Commun. | volume = 279 | issue = 2 | pages = 324}}</ref> Mice lacking GCLM demonstrate no outward phenotype, but exhibit marked decrease in GSH and increased sensitivity to toxic insults.<ref>Yang Y, et al. (2002) J Biol Chem. 277(51):4944.</ref> <ref>Giordano G, et al. (2007) Toxicol Appl Pharmacol. 219(2-3):181.</ref> <ref>McConnachie LA, et al. (2007) Tox Sci Epub 21 June.</ref>
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInNursing=There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGender=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific gender populations.
|useInRace=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific racial populations.
|useInRenalImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with renal impairment.
|useInHepaticImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with hepatic impairment.
|useInReproPotential=There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
|useInImmunocomp=There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.


While all cells in the human body are capable of synthesizing glutathione, liver glutathione synthesis has been shown to be essential.   Following birth, mice with genetically-induced loss of GCLC (i.e., GSH synthesis) only in the liver die within 1 month of birth.<ref>Chen Y, et al. (2007) Hepatology 45:1118.</ref>  
<!--Administration and Monitoring-->
|administration=* Oral
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
|IVCompat=There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.
|drugBox=[[File:Glutathione drugbox.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.
|PK=There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.
|nonClinToxic=There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.
|clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.
|packLabel=<!--Patient Counseling Information-->
|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.
|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
|brandNames=GLUTATHIONE
|drugShortage=
}}
{{LabelImage
|fileName=Glutathione fig.jpg
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{{LabelImage
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<!--Pill Image-->


The biosynthesis pathway for glutathione is found in some bacteria, like [[cyanobacteria]] and [[proteobacteria]], but is missing in many other bacteria. Most eukaryotes synthesize glutathione, including humans, but some do not, such as ''Leguminosae'', ''[[Entamoeba]]'', and ''[[Giardia]]''. The only archaea that make glutathione are [[halobacteria]].<ref>{{cite journal | author=| title=Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes| journal=Genome biology| year=2002| volume=3| url=http://genomebiology.com/2002/3/5/RESEARCH/0025}}</ref><ref>{{cite book | title=Significance of glutathione in plant adaptation to the environment| url=http://books.google.com/books?hl=sv&lr=&id=aX2eJf1i67IC&oi=fnd&pg=PA13&ots=8feo-QOEPa&sig=XAMjZ0Wan17vmoUKg_FFNRl8g0I#PPP1,M1| author=Grill D, Tausz T, De Kok LJ| date=2001| publisher=Springer| isbn=1402001789}}</ref>


==Function==
Glutathione exists in reduced (GSH) and oxidized (GSSG) states.  In the reduced state, the thiol group of cysteine is able to donate a [[reducing equivalent]] (H<sup>+</sup>+ e<sup>-</sup>) to other unstable molecules, such as reactive oxygen species.  In donating an electron, glutathione itself becomes reactive, but readily reacts with another reactive glutathione to form glutathione disulfide (GSSG).  Such a reaction is possible due to the relatively high concentration of gluathione in cells (up to 5 mM in the liver).  GSH can be regenerated from GSSG by the enzyme glutathione reductase.


In healthy cells and tissue, more than 90% of the total glutathione pool is in the reduced form (GSH) and less than 10% exists in the disulfide form (GSSG). An increased GSSG-to-GSH ratio is considered indicative of oxidative stress.
<!--Label Display Image-->


GSH is known as a [[Substrate (biochemistry)|substrate]] in both [[Conjugated system|conjugation]] reactions and [[Redox|reduction]] reactions, catalyzed by [[glutathione S-transferase]] enzymes in [[cytosol]], [[microsome]]s, and [[mitochondria]].  However, it is also capable of participating in non-enzymatic conjugation with some chemicals, as in the case of n-acetyl-''p''-benzoquinone imine ([[NAPQI]]), the reactive [[cytochrome P450 oxidase|cytochrome P450]]-reactive [[metabolite]] formed by [[paracetamol]] (or [[acetaminophen]] as it is known in the US), that becomes toxic when GSH is depleted by an overdose of acetaminophen.


Glutathione in this capacity binds to NAPQI as a [[suicide inhibitor]] and in the process detoxifies it, taking the place of cellular protein thiol groups, which would otherwise be covalently modified; when all GSH has been spent, NAPQI begins to react with the cellular [[protein]]s, killing the cells in the process. The preferred treatment for an overdose of this painkiller is the administration (usually in atomized form) of [[acetylcysteine|N-acetyl-L-cysteine]], which is processed by cells to L-cysteine and used in the de novo synthesis of GSH.


Glutathione (GSH) participates in [[leukotriene]] synthesis and is a [[cofactor (biochemistry)|cofactor]] for the [[enzyme]] [[glutathione peroxidase]]. It is also important as a [[hydrophilic]] molecule that is added to [[lipophilic]] toxins and waste in the liver during [[biotransformation]] before they can become part of the [[bile]]. Glutathione is also needed for the detoxification of [[methylglyoxal]], a toxin produced as a by-product of metabolism.


This detoxification reaction is carried out by the [[glyoxalase system]]. Glyoxalase I [http://us.expasy.org/enzyme/4.4.1.5 (EC 4.4.1.5)] catalyzes the conversion of methylglyoxal and reduced glutathione to S-D-Lactoyl-glutathione. Glyoxalase II [http://us.expasy.org/enzyme/3.1.2.6 (EC 3.1.2.6)] catalyzes the hydrolysis of S-D-Lactoyl-glutathione to glutathione and D-lactate.


== Supplementation ==
<!--Category-->
Supplementing has been difficult, as research suggests that glutathione taken orally is not well absorbed across the GI tract. In a study of acute oral administration of a very large dose (3 grams) of oral glutathione, ''Witschi and coworkers'' found that "it is not possible to increase circulating glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 g of glutathione."<ref>[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1362956&query_hl=1&itool=pubmed_docsum Witschi A, et. al. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43(6):667-9]</ref>, <ref>[http://www.aegis.com/aidsline/1993/may/M9350657.html AIDS Line Update]</ref>.
However, tissue and serum glutathione concentrations can be raised by increased intake of the precursor [[cysteine]].  Glutathione precursors rich in cysteine include [[Acetylcysteine]] (NAC),<ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?dispmax=50&db=pubmed&pmfilter_EDatLimit=added%20to%20PubMed%20in%20the%20last%200%20i&cmd_current=Limits&orig_db=PubMed&cmd=Search&term=Acetylcysteine+glutathione%20&doptcmdl=DocSum Acetylcysteine and glutathione, PubMed]</ref> [[undenatured]] [[whey protein]] <ref>[http://www.nutritionadvisor.com/glutathione.html Glutathione information for Physicians]</ref>, <ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11168457&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Micke et al. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. Eur J Clin Invest. 2001 Feb;31(2):171-8.]</ref>, <ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16014759&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Moreno et al. Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection. J Trop Pediatr. 2006 Feb;52(1):34-8. Epub 2005 Jul 13.]</ref>, <ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15463873&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Lands et al. Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein. J Cyst Fibros. 2003 Dec;2(4):195-8.]</ref>, <ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11990003&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Micke et al. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur J Nutr. 2002 Feb;41(1):12-8.]</ref>, <ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=8365048&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Bounous et al. Whey proteins as a food supplement in HIV-seropositive individuals. Clin Invest Med. 1993 Jun;16(3):204-9.]</ref>, <ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=1782728&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Bounous et al. The biological activity of undenatured dietary whey proteins: role of glutathione. Clin Invest Med. 1991 Aug;14(4):296-309]</ref>, <ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Bounous%20G%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Bounous et al. Multiple references on glutathione enhancement with bioactive whey protein in multiple disease states]</ref>and [[acetylcysteine|N-acetyl-cysteine]] <ref>[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8299004&dopt=Citation Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard.]</ref> have been shown to increase glutathione content within the cell. [[N-acetylcysteine]] is a generically available supplement which has been demonstrated to increase intracellular reduced and total glutathione by 92% and 58% respectively. <ref>[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&list_uids=8207209&dopt=citation Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2]</ref> 
All of the published clinical studies using bioactive whey proteins mentioned in the references above used a form of a bioactive whey protein and bonded [[cystine]] dietary supplement derived from [[lactose]]-free [[Organic product|organic]] milk (whey protein) called Immunocal. This whey protein is clinically proven to increase glutathione levels within the [[lymphocytes]] of the immune system by 35.5% while increasing peak power and muscular performance by 13%. <ref>[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10517767&query_hl=6&itool=pubmed_DocSum L.C. Lands, V.L. Grey, and A.A. Smountas. Effect of supplementation with cysteine donor on muscular performance. J Appl Ph. 1999 Oct,87(4):138-5.]</ref>
 
==Pathology==
Excess glutamate at [[synapse]]s, which may be released in conditions such as [[traumatic brain injury]], can prevent the uptake of [[cysteine]], a necessary building block of glutathione.  Without the protection from oxidative injury afforded by glutathione, cells may be damaged or killed.<ref>
{{cite journal
| author = Pereira C.F, de Oliveira C.R.
| year = 2000
| month = July
| title = Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis
| journal = Neuroscience Research
| volume = 37
| issue = 3
| pages = 227-236
| doi = doi:10.1016/S0168-0102(00)00124-3
| accessdate = 2006-05-05
}}</ref>
 
==See also==
*[[Glutathione synthetase deficiency]]
 
== References ==
{{reflist|2}}
 
== Related research ==
*The antioxidant glutathione peroxidase family and spermatozoa: A complex story. PMID 16427183
*[http://www.fda.gov/ohrms/dockets/ac/00/slides/3652s1_05/ The Role of Glutathione in Cell Defense.]
* Glutathione metabolism and its implications for health. PMID 14988435
* The changing faces of glutathione, a cellular protagonist. PMID 14555227
*[[Ophthalmic acid]]
 
{{Antidotes}}
{{Enzyme cofactors}}


[[Category:Peptides]]
[[Category:Antioxidants]]
[[Category:Thiols]]
[[Category:Thiols]]
[[Category:Peptides]]
[[Category:Drug]]
 
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[[ru:Глутатион]]
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{{WikiDoc Sources}}

Latest revision as of 16:25, 20 August 2015

Glutathione
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Disclaimer

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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Glutathione is an amino acid supplement that is FDA approved for the treatment of chronic fatigue, muscle aches and pain. Common adverse reactions include cutaneous eruptions.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

  • For temporary relief of chronic fatigue, muscle aches and pain, lowered immune response, and sensitivity to environmental chemicals.

Dosage

  • 10 drops orally, 3 times a day.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Glutathione in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Glutathione in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Glutathione in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Glutathione in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Glutathione in pediatric patients.

Contraindications

  • Prior hypersensitivity to glutathione

Warnings

  • If pregnant or breast-feeding, ask a health care professional before use.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
  • Do not use if tamper evident seal is broken or missing. Store in a cool, dry place.

Adverse Reactions

Clinical Trials Experience

  • cutaneous eruptions

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Glutathione in the drug label.

Drug Interactions

There is limited information regarding Glutathione Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Glutathione in women who are pregnant.
Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Glutathione in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Glutathione during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Glutathione with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Glutathione with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Glutathione with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Glutathione with respect to specific gender populations.

Race

There is no FDA guidance on the use of Glutathione with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Glutathione in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Glutathione in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Glutathione in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Glutathione in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral

Monitoring

There is limited information regarding Monitoring of Glutathione in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Glutathione in the drug label.

Overdosage

There is limited information regarding Glutathione overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

This image is provided by the National Library of Medicine.

Mechanism of Action

There is limited information regarding Glutathione Mechanism of Action in the drug label.

Structure

There is limited information regarding Glutathione Structure in the drug label.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Glutathione in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Glutathione in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Glutathione in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Glutathione in the drug label.

How Supplied

There is limited information regarding Glutathione How Supplied in the drug label.

Storage

There is limited information regarding Glutathione Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Glutathione |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Glutathione |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Glutathione in the drug label.

Precautions with Alcohol

  • Alcohol-Glutathione interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

GLUTATHIONE

Look-Alike Drug Names

There is limited information regarding Glutathione Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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