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Glucuronosyltransferase - Revision history
2024-03-28T14:12:50Z
Revision history for this page on the wiki
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2012-09-04T17:53:09Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:53, 4 September 2012</td>
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2012-08-09T15:35:02Z
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<p><b>New page</b></p><div>{{Protein<br />
|Name={{PAGENAME}}<br />
|image=<br />
|caption=<br />
|Symbol=UGT1A1<br />
|AltSymbols=<br />
|HGNCid=12530<br />
|Chromosome=2<br />
|Arm=q<br />
|Band=37<br />
|LocusSupplementaryData=<br />
|ECnumber=2.4.1.17<br />
|OMIM=191740<br />
|EntrezGene=54658<br />
|RefSeq=NM_000463<br />
|UniProt=P22309<br />
|PDB=<br />
}}<br />
{{SI}}<br />
<br />
<br />
==Overview==<br />
'''Uridine 5'-diphospho-glucuronosyltransferase''' (UDP-glucuronosyltransferase, UGT) is a [[glycosyltransferase]] ({{EC number|2.4.1.17}}) that [[catalyst|catalyzes]] the [[glucuronidation]] reaction.<ref>{{cite journal |author=King C, Rios G, Green M, Tephly T |title=UDP-glucuronosyltransferases |journal=Curr Drug Metab |volume=1 |issue=2 |pages=143-61 |year=2000 |pmid=11465080}}</ref> <br />
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''Alternative names:''<br />
*glucuronyltransferase<br />
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==Function==<br />
This reaction involves the addition of sugars to lipids and other apolar xenobiotics and is an important step in the body's elimination of foreign substances (such as drugs and medications) as well as endogenous substances (including endogenous toxins). UGT is present in humans, other animals, plants, and bacteria. <br />
<br />
The glucuronidation reaction consists of the transfer of the [[glucuronosyl]] group from [[uridine 5'-diphospho-glucuronic acid]] (UDPGA) to [[Substrate (biochemistry)|substrate]] molecules that contain oxygen, nitrogen, sulfur or carboxyl functional groups.<ref>{{cite journal |author=Bock K, Köhle C |title=UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects |journal=Methods Enzymol |volume=400 |issue= |pages=57-75 |year= |pmid=16399343}}</ref> <br />
The resulting [[glucuronide]] more polar (e.g. hydrophilic) and is more easily excreted than the substrate molecule. The product solubility in blood is increased allowing it to be eliminated from the body by the [[kidney]]s.<br />
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==Diseases==<br />
A deficiency in the bilirubin specific form of glucuronosyltransferase is thought to be the cause of [[Gilbert's syndrome]], which is characterized by [[hyperbilirubinemia]].<br />
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It is also associated with [[Crigler-Najjar syndrome]], a more serious disorder where the enzyme's activity is either completely absent (Crigler-Najjar syndrome type I) or less than 10% of normal (type II).<br />
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==Genes==<br />
* {{Gene|B3GAT1}}, {{Gene|B3GAT2}}, {{Gene|B3GAT3}}<br />
<br />
* {{Gene|UGT1A1}}, {{Gene|UGT1A3}}, {{Gene|UGT1A4}}, {{Gene|UGT1A5}}, {{Gene|UGT1A6}}, {{Gene|UGT1A7}}, {{Gene|UGT1A8}}, {{Gene|UGT1A9}}, {{Gene|UGT1A10}}<br />
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* {{Gene|UGT2A1}}, {{Gene|UGT2A2}}, {{Gene|UGT2A3}}, {{Gene|UGT2B4}}, {{Gene|UGT2B7}}, {{Gene|UGT2B10}}, {{Gene|UGT2B11}}, {{Gene|UGT2B15}}, {{Gene|UGT2B17}}, {{Gene|UGT2B28}}<br />
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==External links==<br />
* {{MeshName|Glucuronosyltransferase}}<br />
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==References==<br />
{{reflist}}<br />
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{{Glycosyltransferases}}<br />
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[[Category:Transferases]]<br />
[[Category:EC 2.4.1]]<br />
{{WH}}<br />
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