Glucose-insulin-potassium infusion

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Synonyms and keywords:: GIK

Overview

GIK is a pharmacologic regimen that has been extensively studied as adjunctive therapy in STEMI patients to reduce reperfusion injury. The majority of recent trials do not demonstrate a benefit on clinical outcomes.[1] [2] [3] [4] [5] [6] [6] [7] [8] [9] [10] [11] [12] [13] [14]

References

  1. "Potassium, glucose, and insulin treatment for acute myocardial infarction". Lancet. 2 (7583): 1355–60. 1968. PMID 4177929. Unknown parameter |month= ignored (help)
  2. Pentecost BL, Mayne NM, Lamb P (1968). "Controlled trial of intravenous glucose, potassium, and insulin in acute myocardial infarction". Lancet. 1 (7549): 946–8. PMID 4171584. Unknown parameter |month= ignored (help)
  3. Apstein CS, Opie LH (1999). "Glucose-insulin-potassium (GIK) for acute myocardial infarction: a negative study with a positive value" (PDF). Cardiovasc Drugs Ther. 13 (3): 185–9. PMID 10439880. Unknown parameter |month= ignored (help)
  4. Fath-Ordoubadi F, Beatt KJ (1997). "Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials". Circulation. 96 (4): 1152–6. PMID 9286943. Unknown parameter |month= ignored (help)
  5. Rogers WJ, Stanley AW, Breinig JB; et al. (1976). "Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion". Am. Heart J. 92 (4): 441–54. PMID 785990. Unknown parameter |month= ignored (help)
  6. 6.0 6.1 Rackley CE, Russell RO, Rogers WJ, Mantle JA, McDaniel HG, Papapietro SE (1982). "Glucose-insulin-potassium administration in acute myocardial infarction". Annu. Rev. Med. 33: 375–83. doi:10.1146/annurev.me.33.020182.002111. PMID 7044275.
  7. Satler LF, Green CE, Kent KM, Pallas RS, Pearle DL, Rackley CE (1987). "Metabolic support during coronary reperfusion". Am. Heart J. 114 (1 Pt 1): 54–8. PMID 3300232. Unknown parameter |month= ignored (help)
  8. Malmberg K, Rydén L, Efendic S; et al. (1995). "Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year". J. Am. Coll. Cardiol. 26 (1): 57–65. PMID 7797776. Unknown parameter |month= ignored (help)
  9. Díaz R, Paolasso EA, Piegas LS; et al. (1998). "Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiológicos Latinoamérica) Collaborative Group". Circulation. 98 (21): 2227–34. PMID 9867443. Unknown parameter |month= ignored (help)
  10. Ceremuzyński L, Budaj A, Czepiel A; et al. (1999). "Low-dose glucose-insulin-potassium is ineffective in acute myocardial infarction: results of a randomized multicenter Pol-GIK trial" (PDF). Cardiovasc Drugs Ther. 13 (3): 191–200. PMID 10439881. Unknown parameter |month= ignored (help)
  11. van der Horst IC, Zijlstra F, van 't Hof AW; et al. (2003). "Glucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: the glucose-insulin-potassium study: a randomized trial". J. Am. Coll. Cardiol. 42 (5): 784–91. PMID 12957421. Unknown parameter |month= ignored (help)
  12. Sack MN, Yellon DM (2003). "Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulation". J. Am. Coll. Cardiol. 41 (8): 1404–7. PMID 12706939. Unknown parameter |month= ignored (help)
  13. Stanley AW, Moraski RE, Russell RO; et al. (1975). "Effects of glucose-insulin-potassium on myocardial substrate availability and utilization in stable coronary artery disease. Studies on myocardial carbohydrate, lipid and oxygen arterial-coronary sinus differences in patients with coronary artery disease". Am. J. Cardiol. 36 (7): 929–37. PMID 1199950. Unknown parameter |month= ignored (help)
  14. Hjermann I (1971). "A controlled study of peroral glucose, insulin and potassium treatment in myocardial infarction". Acta Med Scand. 190 (3): 213–8. PMID 4941225. Unknown parameter |month= ignored (help)

Category:Cardiology