Glucagonoma laboratory tests: Difference between revisions

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==Laboratory Findings==
==Laboratory Findings==
The laboratory findings associated with glucagonoma are:<ref name="pmid15313692" /><ref name="pmid8606627" /><ref name="pmid17873310">{{cite journal| author=Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET et al.| title=Endocrine [[pancreatic tumors]] with [[glucagon]] hypersecretion: a retrospective study of 23 cases during 20 years. | journal=Med Oncol | year= 2007 | volume= 24 | issue= 3 | pages= 330-7 | pmid=17873310 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17873310 }}</ref><ref name="pmid8606627">{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 2 | pages= 53-63 | pmid=8606627 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8606627 }}</ref>
The laboratory findings associated with glucagonoma are:<ref name="pmid15313692" /><ref name="pmid8606627" /><ref name="pmid17873310">{{cite journal| author=Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET et al.| title=Endocrine [[pancreatic tumors]] with [[glucagon]] hypersecretion: a retrospective study of 23 cases during 20 years. | journal=Med Oncol | year= 2007 | volume= 24 | issue= 3 | pages= 330-7 | pmid=17873310 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17873310  }}</ref>


'''Serum glucagon'''
'''Serum glucagon'''
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'''Other laboratory findings'''
'''Other laboratory findings'''
* Blood tests may also reveal low concentrations of [[amino acids]], [[zinc]], and [[essential fatty acid]]s.
* Blood tests may also reveal low concentrations of [[amino acids]], [[zinc]], and [[essential fatty acid]]s.
* A [[complete blood count|complete blood count]] ([[complete blood count|CBC]]) to diagnose [[anemia]]
* A [[complete blood count|complete blood count]] ([[complete blood count|CBC]]) to diagnose [[anemia]].


==References==
==References==

Revision as of 15:58, 20 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2], Mohammed Abdelwahed M.D[3]

Overview

Laboratory findings consistent with the diagnosis of glucagonoma include a serum glucagon concentration of 1000 pg/ml or greater.[1][2]

Laboratory Findings

The laboratory findings associated with glucagonoma are:[1][3][4]

Serum glucagon

  • Increased plasma glucagon levels >500 pg/mL (Normal glucagon level is less than 50 pg/mL).
  • Concentrations above 1000 pg/mL are diagnostic of glucagonoma.
  • Some conditions can increase glucagon level to a level less than 500 pg/mL such as fasting and hypoglycemia.
  • Some symptomatic glucagonomas are associated with normal glucagon serum level. So, a serum glucagon concentration below 500 pg/mL does not exclude a glucagonoma.[4]

Other laboratory findings

References

  1. 1.0 1.1 Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS (2004). "Clinical experience in diagnosis and treatment of glucagonoma syndrome". Hepatobiliary Pancreat Dis Int. 3 (3): 473–5. PMID 15313692.
  2. Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. Accessed on October 15,2015
  3. 4.0 4.1 Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET; et al. (2007). "Endocrine [[pancreatic tumors]] with [[glucagon]] hypersecretion: a retrospective study of 23 cases during 20 years". Med Oncol. 24 (3): 330–7. PMID 17873310. URL–wikilink conflict (help)

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