Glucagonoma history and symptoms: Difference between revisions

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Revision as of 17:57, 8 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History and Symptoms

Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.

References

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 ==History and Symptoms==
-* The primary [[physiology|physiological]] effect of glucagonoma is an overproduction of the [[peptide]] hormone [[glucagon]], which enhances [[blood glucose]] levels through the activation of [[catabolism|catabolic]] processes including [[gluconeogenesis]] and [[lipolysis]]. Gluconeogenesis produces [[glucose]] from [[protein]] and [[amino acid]] materials; lipolysis is the breakdown of [[adipose tissue|fat]]. The net result is hyperglucagonemia, decreased blood levels of [[amino acid]]s (hypoaminoacidemia), [[anemia]], [[diarrhea]], and weight loss of 5-15 [[kilogram|kg]].
 * [[Necrolytic migratory erythema]] (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower [[abdomen]], [[buttock]]s, [[perineum]], and [[groin]].
-* [[Diabetes mellitus]] also frequently results from the [[insulin]] and [[glucagon]] imbalance that occurs in glucagonoma.<ref>{{cite journal |author=Koike N, Hatori T, Imaizumi T, ''et al'' |title=Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus |journal=Journal of hepato-biliary-pancreatic surgery |volume=10 |issue=1 |pages=101-5 |year=2003 |pmid=12918465 |doi=}}</ref> Diabetes mellitus is present in 80-90% of cases of glucagonoma, and is exacerbated by preexisting [[insulin resistance]].
 ==References==

Glucagonoma history and symptoms: Difference between revisions

Revision as of 17:57, 8 October 2015

Overview

History and Symptoms

References

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