Glioblastoma multiforme pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathophysiology

Genetics

• Almost all cases of GBM are sporadic, without a familial predilection, although chromosomal aberrations such as PTEN mutation, and p53 mutation are commonly seen in these tumors.
• Growth factor aberrant signaling associated with EGFR, and PDGF are also seen.

Associated Conditions

Glioblastoma may be associated with:

• Neurofibromatosis type 1
• Li-Fraumeni syndrome
• Turcot syndrome
• Ollier disease
• Maffucci syndrome

Microscopic Pathology

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  Glioblastoma (histology slide)

References

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