Glioblastoma multiforme medical therapy: Difference between revisions

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==Overview==
==Overview==
The predominant therapy for glioblastoma multiforme is [[surgical resection]]. Adjunctive [[chemotherapy]] and [[radiation]] may be required.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref><ref name="pmid25468225">{{cite journal| author=Barani IJ, Larson DA| title=Radiation therapy of glioblastoma. | journal=Cancer Treat Res | year= 2015 | volume= 163 | issue=  | pages= 49-73 | pmid=25468225 | doi=10.1007/978-3-319-12048-5_4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25468225  }} </ref><ref name="pmid20044633">{{cite journal| author=Minniti G, Muni R, Lanzetta G, Marchetti P, Enrici RM| title=Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents. | journal=Anticancer Res | year= 2009 | volume= 29 | issue= 12 | pages= 5171-84 | pmid=20044633 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20044633  }} </ref> Supportive therapy for glioblastoma multiforme includes [[anticonvulsants]] and [[corticosteroids]].Cytotoxic therapy for GBM has evolved due to the approval of temozolomide,an alkylating agent- for newly diagnosed GBM.
The predominant therapy for glioblastoma multiforme is [[surgical resection]]. Adjunctive [[chemotherapy]] and [[radiation]] may be required.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref><ref name="pmid25468225">{{cite journal| author=Barani IJ, Larson DA| title=Radiation therapy of glioblastoma. | journal=Cancer Treat Res | year= 2015 | volume= 163 | issue=  | pages= 49-73 | pmid=25468225 | doi=10.1007/978-3-319-12048-5_4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25468225  }} </ref><ref name="pmid20044633">{{cite journal| author=Minniti G, Muni R, Lanzetta G, Marchetti P, Enrici RM| title=Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents. | journal=Anticancer Res | year= 2009 | volume= 29 | issue= 12 | pages= 5171-84 | pmid=20044633 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20044633  }} </ref> Supportive therapy for glioblastoma multiforme includes [[anticonvulsants]] and [[corticosteroids]].Cytotoxic therapy for GBM has evolved due to the approval of temozolomide,an alkylating agent- for newly diagnosed GBM. Active agents include also the nitrosureas which include carmustine and lomustine, platinum agents, etoposide, irinotecan and PCV combination.


==Medical Therapy==
==Medical Therapy==

Revision as of 14:52, 25 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]

Overview

The predominant therapy for glioblastoma multiforme is surgical resection. Adjunctive chemotherapy and radiation may be required.[1][2][3] Supportive therapy for glioblastoma multiforme includes anticonvulsants and corticosteroids.Cytotoxic therapy for GBM has evolved due to the approval of temozolomide,an alkylating agent- for newly diagnosed GBM. Active agents include also the nitrosureas which include carmustine and lomustine, platinum agents, etoposide, irinotecan and PCV combination.

Medical Therapy

The predominant therapy for glioblastoma multiforme is surgical resection. Adjunctive chemotherapy and radiation may be required.[1][2][3]

Radiotherapy

  • Post-operative radiotherapy is recommended among all patients who develop glioblastoma multiforme.
  • Adjuvant radiotherapy can reduce the tumor size to 107 cells.
  • Radiotherapy may not cure the cancer, but can control the tumor and delay recurrence.
  • Targeted three-dimensional conformal radiotherapy is preferred to whole brain radiotherapy.
  • Total radiation dose of 5,000-6,000 cGy has been found to be optimal for treatment.[2]

Chemotherapy

Supportive treatment

Supportive therapy for glioblastoma multiforme includes anticonvulsants and corticosteroids, which focuses on relieving symptoms and improving the patient’s neurologic function.

References

  1. 1.0 1.1 Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma
  2. 2.0 2.1 2.2 Barani IJ, Larson DA (2015). "Radiation therapy of glioblastoma". Cancer Treat Res. 163: 49–73. doi:10.1007/978-3-319-12048-5_4. PMID 25468225.
  3. 3.0 3.1 3.2 3.3 Minniti G, Muni R, Lanzetta G, Marchetti P, Enrici RM (2009). "Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents". Anticancer Res. 29 (12): 5171–84. PMID 20044633.


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