Glioblastoma multiforme differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Differentiating Glioblastoma multiforme from other Diseases

Glioblastoma must be differentiated from:

Differential diagnosis	Characteristic features
Cerebral metastasis	May look identical Both may appear multifocal Metastases are centred on grey-white matter junction and spare the overlying cortex
Primary CNS lymphoma	Seen in patients with AIDS Central necrosis is more common Homogeneously enhancing on MRI
Cerebral abscess	Central restricted diffusion is helpful Hemorrhagic then assessment may be difficult Presence of smooth and complete SWI low intensity rim Presence of dual rim sign
Anaplastic astrocytoma	No central necrosis
Tumefactive demyelination	Can appear similar Open ring pattern of enhancement Younger patients
Stroke	History is suggestive of diagnosis No elevated choline
Cerebral toxoplasmosis	Seen in patients with AIDS

• Essential seizures
• Stroke
• Chronic subdural hematoma
• Meningitis
• Orbital optic neuritis
• Intraocular optic neuritis

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